| UniProt ID | AMACR_HUMAN | |
|---|---|---|
| UniProt AC | Q9UHK6 | |
| Protein Name | Alpha-methylacyl-CoA racemase | |
| Gene Name | AMACR | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 382 | |
| Subcellular Localization | Peroxisome . Mitochondrion . | |
| Protein Description | Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.. | |
| Protein Sequence | MALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAAVLRRLCKRSDVLLEPFRRGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVIDANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGLGLKSDELPNQMSMDDWPEMKKKFADVFAEKTKAEWCQIFDGTDACVTPVLTFEEVVHHDHNKERGSFITSEEQDVSPRPAPLLLNTPAIPSFKRDPFIGEHTEEILEEFGFSREEIYQLNSDKIIESNKVKASL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 58 | Malonylation | RSLVLDLKQPRGAAV CEEEEECCCCCHHHH | 58.90 | 26320211 | |
| 58 (in isoform 5) | Malonylation | - | 58.90 | 26320211 | |
| 58 | Ubiquitination | RSLVLDLKQPRGAAV CEEEEECCCCCHHHH | 58.90 | - | |
| 58 | Acetylation | RSLVLDLKQPRGAAV CEEEEECCCCCHHHH | 58.90 | - | |
| 87 | Acetylation | FRRGVMEKLQLGPEI HHHHHHHHHCCCHHH | 24.36 | - | |
| 87 | Ubiquitination | FRRGVMEKLQLGPEI HHHHHHHHHCCCHHH | 24.36 | - | |
| 87 | Succinylation | FRRGVMEKLQLGPEI HHHHHHHHHCCCHHH | 24.36 | - | |
| 87 | Succinylation | FRRGVMEKLQLGPEI HHHHHHHHHCCCHHH | 24.36 | - | |
| 115 | Phosphorylation | SGFGQSGSFCRLAGH CCCCCCCCCHHHCCC | 26.81 | - | |
| 126 (in isoform 2) | Phosphorylation | - | 8.16 | - | |
| 126 (in isoform 4) | Phosphorylation | - | 8.16 | - | |
| 126 | Phosphorylation | LAGHDINYLALSGVL HCCCCCHHHHHHHHH | 8.16 | 68751039 | |
| 130 (in isoform 4) | Phosphorylation | - | 22.65 | - | |
| 130 (in isoform 2) | Phosphorylation | - | 22.65 | - | |
| 135 | Ubiquitination | ALSGVLSKIGRSGEN HHHHHHHHHCCCCCC | 45.05 | 23000965 | |
| 153 (in isoform 4) | Phosphorylation | - | 5.91 | - | |
| 153 (in isoform 2) | Phosphorylation | - | 5.91 | - | |
| 198 | Phosphorylation | LSSFLWKTQKLSLWE HHHHHHHHCCCCCEE | 21.25 | 29083192 | |
| 202 | Phosphorylation | LWKTQKLSLWEAPRG HHHHCCCCCEECCCC | 38.17 | 29083192 | |
| 268 | Succinylation | MDDWPEMKKKFADVF CCCHHHHHHHHHHHH | 51.67 | - | |
| 268 | Succinylation | MDDWPEMKKKFADVF CCCHHHHHHHHHHHH | 51.67 | - | |
| 324 | Phosphorylation | TSEEQDVSPRPAPLL CCCCCCCCCCCCCCC | 24.39 | 28857561 | |
| 365 | Phosphorylation | GFSREEIYQLNSDKI CCCHHHHHCCCCCHH | 15.38 | 110760055 | |
| 365 (in isoform 5) | Phosphorylation | - | 15.38 | 27642862 | |
| 371 | Ubiquitination | IYQLNSDKIIESNKV HHCCCCCHHHHCCCC | 45.46 | 29967540 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AMACR_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AMACR_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AMACR_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| FKBP5_HUMAN | FKBP5 | physical | 28514442 | |
| PSMG3_HUMAN | PSMG3 | physical | 28514442 | |
| PSMG4_HUMAN | PSMG4 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
