| UniProt ID | HAOX2_HUMAN | |
|---|---|---|
| UniProt AC | Q9NYQ3 | |
| Protein Name | Hydroxyacid oxidase 2 | |
| Gene Name | HAO2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 351 | |
| Subcellular Localization | Peroxisome. | |
| Protein Description | Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids.. | |
| Protein Sequence | MSLVCLTDFQAHAREQLSKSTRDFIEGGADDSITRDDNIAAFKRIRLRPRYLRDVSEVDTRTTIQGEEISAPICIAPTGFHCLVWPDGEMSTARAAQAAGICYITSTFASCSLEDIVIAAPEGLRWFQLYVHPDLQLNKQLIQRVESLGFKALVITLDTPVCGNRRHDIRNQLRRNLTLTDLQSPKKGNAIPYFQMTPISTSLCWNDLSWFQSITRLPIILKGILTKEDAELAVKHNVQGIIVSNHGGRQLDEVLASIDALTEVVAAVKGKIEVYLDGGVRTGNDVLKALALGAKCIFLGRPILWGLACKGEHGVKEVLNILTNEFHTSMALTGCRSVAEINRNLVQFSRL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSLVCLTDF ------CCEEECHHH | 29.52 | 28857561 | |
| 7 | Phosphorylation | -MSLVCLTDFQAHAR -CCEEECHHHHHHHH | 29.64 | 24043423 | |
| 175 | Methylation | DIRNQLRRNLTLTDL HHHHHHHHCCCHHHC | 51.61 | - | |
| 178 | Phosphorylation | NQLRRNLTLTDLQSP HHHHHCCCHHHCCCC | 31.03 | 14702039 | |
| 180 | Phosphorylation | LRRNLTLTDLQSPKK HHHCCCHHHCCCCCC | 29.45 | 28857561 | |
| 184 | Phosphorylation | LTLTDLQSPKKGNAI CCHHHCCCCCCCCCC | 46.08 | 28857561 | |
| 337 | Phosphorylation | MALTGCRSVAEINRN HHHHCCCHHHHHHHH | 29.74 | - | |
| 349 | Phosphorylation | NRNLVQFSRL----- HHHHHHHHCC----- | 18.64 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HAOX2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HAOX2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HAOX2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| LIPB1_HUMAN | PPFIBP1 | physical | 28514442 | |
| EST1A_HUMAN | SMG6 | physical | 28514442 | |
| PPM1A_HUMAN | PPM1A | physical | 28514442 | |
| RBPMS_HUMAN | RBPMS | physical | 28514442 | |
| RBPS2_HUMAN | RBPMS2 | physical | 28514442 | |
| P20D2_HUMAN | PM20D2 | physical | 28514442 | |
| BCOR_HUMAN | BCOR | physical | 28514442 | |
| ASPC1_HUMAN | ASPSCR1 | physical | 28514442 | |
| TNIP1_HUMAN | TNIP1 | physical | 28514442 | |
| CTGE5_HUMAN | CTAGE5 | physical | 28514442 | |
| UBB_HUMAN | UBB | physical | 28514442 | |
| CYHR1_HUMAN | CYHR1 | physical | 28514442 | |
| TGO1_HUMAN | MIA3 | physical | 28514442 | |
| ZN703_HUMAN | ZNF703 | physical | 28514442 | |
| WNK1_HUMAN | WNK1 | physical | 28514442 | |
| UBAP2_HUMAN | UBAP2 | physical | 28514442 | |
| GSE1_HUMAN | GSE1 | physical | 28514442 | |
| STIP1_HUMAN | STIP1 | physical | 28514442 | |
| SF01_HUMAN | SF1 | physical | 28514442 | |
| HSP7C_HUMAN | HSPA8 | physical | 28514442 | |
| IF4G3_HUMAN | EIF4G3 | physical | 28514442 | |
| TBL1X_HUMAN | TBL1X | physical | 28514442 | |
| TBL1R_HUMAN | TBL1XR1 | physical | 28514442 | |
| TRI33_HUMAN | TRIM33 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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