ACOT4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACOT4_HUMAN
• UniProt AC: Q8N9L9
• Protein Name: Acyl-coenzyme A thioesterase 4
• Gene Name: ACOT4
• Organism: Homo sapiens (Human).
• Sequence Length: 421
• Subcellular Localization: Peroxisome .
• Protein Description: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs..
• Protein Sequence: MSATLILEPPGRCCWNEPVRIAVRGLAPEQRVTLRASLRDEKGALFRAHARYCADARGELDLERAPALGGSFAGLEPMGLLWALEPEKPFWRFLKRDVQIPFVVELEVLDGHDPEPGRLLCQAQHERHFLPPGVRRQSVRAGRVRATLFLPPGPGPFPGIIDIFGIGGGLLEYRASLLAGHGFATLALAYYNFEDLPNNMDNISLEYFEEAVCYMLQHPQVKGPGIGLLGISLGADICLSMASFLKNVSATVSINGSGISGNTAINYKHSSIPPLGYDLRRIKVAFSGLVDIVDIRNALVGGYKNPSMIPIEKAQGPILLIVGQDDHNWRSELYAQTVSERLQAHGKEKPQIICYPGTGHYIEPPYFPLCPASLHRLLNKHVIWGGEPRAHSKAQEDAWKQILAFFCKHLGGTQKTAVPKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	QRVTLRASLRDEKGA HEEEEEHHHCCCCCH	19.94	23532336
42	Acetylation	RASLRDEKGALFRAH EHHHCCCCCHHHHHH	54.49	-
243	Phosphorylation	DICLSMASFLKNVSA HHHHHHHHHHCCCEE	23.59	24719451
313	Succinylation	PSMIPIEKAQGPILL CCCCCCCCCCCCEEE	46.89	-
313	Succinylation	PSMIPIEKAQGPILL CCCCCCCCCCCCEEE	46.89	-
393	Ubiquitination	GEPRAHSKAQEDAWK CCCCCCCHHHHHHHH	44.19	29967540
408	Succinylation	QILAFFCKHLGGTQK HHHHHHHHHHCCCCC	36.39	-
415	Ubiquitination	KHLGGTQKTAVPKL- HHHCCCCCCCCCCC-	37.99	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACOT4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACOT4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACOT4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ACOT4_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.