PTGR3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTGR3_HUMAN
• UniProt AC: Q8N4Q0
• Protein Name: Prostaglandin reductase 3
• Gene Name: ZADH2 {ECO:0000312|HGNC:HGNC:28697}
• Organism: Homo sapiens (Human).
• Sequence Length: 377
• Subcellular Localization: Peroxisome .
• Protein Description: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficienty towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation..
• Protein Sequence: MLRLVPTGARAIVDMSYARHFLDFQGSAIPQAMQKLVVTRLSPNFREAVTLSRDCPVPLPGDGDLLVRNRFVGVNASDINYSAGRYDPSVKPPFDIGFEGIGEVVALGLSASARYTVGQAVAYMAPGSFAEYTVVPASIATPVPSVKPEYLTLLVSGTTAYISLKELGGLSEGKKVLVTAAAGGTGQFAMQLSKKAKCHVIGTCSSDEKSAFLKSLGCDRPINYKTEPVGTVLKQEYPEGVDVVYESVGGAMFDLAVDALATKGRLIVIGFISGYQTPTGLSPVKAGTLPAKLLKKSASVQGFFLNHYLSKYQAAMSHLLEMCVSGDLVCEVDLGDLSPEGRFTGLESIFRAVNYMYMGKNTGKIVVELPHSVNSKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Acetylation	AIPQAMQKLVVTRLS CHHHHHHHHHHHEEC		-
123	Phosphorylation	TVGQAVAYMAPGSFA EHHCHHHHCCCCCCE		20068231
128	Phosphorylation	VAYMAPGSFAEYTVV HHHCCCCCCEEEEEE		20068231
145	Phosphorylation	SIATPVPSVKPEYLT CEECCCCCCCHHHEE		22496350
150	Phosphorylation	VPSVKPEYLTLLVSG CCCCCHHHEEEEEEC		28111955
152	Phosphorylation	SVKPEYLTLLVSGTT CCCHHHEEEEEECCE		28111955
156	Phosphorylation	EYLTLLVSGTTAYIS HHEEEEEECCEEEEE		28111955
158	Phosphorylation	LTLLVSGTTAYISLK EEEEEECCEEEEEHH		28111955
159	Phosphorylation	TLLVSGTTAYISLKE EEEEECCEEEEEHHH		28111955
161	Phosphorylation	LVSGTTAYISLKELG EEECCEEEEEHHHHC		28111955
163	Phosphorylation	SGTTAYISLKELGGL ECCEEEEEHHHHCCC		28111955
174	Acetylation	LGGLSEGKKVLVTAA HCCCCCCCEEEEEEC		30593455
174	Methylation	LGGLSEGKKVLVTAA HCCCCCCCEEEEEEC		-
175	Acetylation	GGLSEGKKVLVTAAA CCCCCCCEEEEEECC		19818077
179	Phosphorylation	EGKKVLVTAAAGGTG CCCEEEEEECCCCHH		22210691
194	Acetylation	QFAMQLSKKAKCHVI HHHHHHHHHCCCEEE		19818085
209	Ubiquitination	GTCSSDEKSAFLKSL ECCCCHHHHHHHHHC		-
214	Ubiquitination	DEKSAFLKSLGCDRP HHHHHHHHHCCCCCC		-
225	Acetylation	CDRPINYKTEPVGTV CCCCCCCCCCCCCCE		25953088
225	Ubiquitination	CDRPINYKTEPVGTV CCCCCCCCCCCCCCE		-
279	Phosphorylation	ISGYQTPTGLSPVKA ECCCCCCCCCCCCCC		28348404
282	Phosphorylation	YQTPTGLSPVKAGTL CCCCCCCCCCCCCCC		24719451
299	Phosphorylation	KLLKKSASVQGFFLN HHHHHCCCHHHHHHH		14702039
357	Phosphorylation	FRAVNYMYMGKNTGK HHHHHHHHCCCCCCC		30257219

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTGR3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTGR3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTGR3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
MD1L1_HUMAN	MAD1L1	physical	28514442
CCNB1_HUMAN	CCNB1	physical	28514442
CG043_HUMAN	C7orf43	physical	28514442
ODB2_HUMAN	DBT	physical	28514442
TPC10_HUMAN	TRAPPC10	physical	28514442
CKS2_HUMAN	CKS2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.