NUDT7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUDT7_HUMAN
• UniProt AC: P0C024
• Protein Name: Peroxisomal coenzyme A diphosphatase NUDT7
• Gene Name: NUDT7
• Organism: Homo sapiens (Human).
• Sequence Length: 238
• Subcellular Localization: Peroxisome.
• Protein Description: Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity)..
• Protein Sequence: MSRLGLPEEPVRNSLLDDAKARLRKYDIGGKYSHLPYNKYSVLLPLVAKEGKLHLLFTVRSEKLRRAPGEVCFPGGKRDPTDMDDAATALREAQEEVGLRPHQVEVVCCLVPCLIDTDTLITPFVGLIDHNFQAQPNPAEVKDVFLVPLAYFLHPQVHDQHYVTRLGHRFINHIFEYTNPEDGVTYQIKGMTANLAVLVAFIILEKKPTFEVQFNLNDVLASSEELFLKVHKKATSRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSRLGLPEE ------CCCCCCCCC	35.89	24719451
20	Succinylation	NSLLDDAKARLRKYD CCHHHHHHHHHHHCC	40.82	-
20	Ubiquitination	NSLLDDAKARLRKYD CCHHHHHHHHHHHCC	40.82	-
20	Succinylation	NSLLDDAKARLRKYD CCHHHHHHHHHHHCC	40.82	-
26	Phosphorylation	AKARLRKYDIGGKYS HHHHHHHCCCCCCCC	13.32	-
32	Phosphorylation	KYDIGGKYSHLPYNK HCCCCCCCCCCCCCC	12.47	22461510
33	Phosphorylation	YDIGGKYSHLPYNKY CCCCCCCCCCCCCCC	23.25	22461510
37	Phosphorylation	GKYSHLPYNKYSVLL CCCCCCCCCCCEEHH	30.55	22461510
40	Phosphorylation	SHLPYNKYSVLLPLV CCCCCCCCEEHHHHH	10.60	-
58	Phosphorylation	GKLHLLFTVRSEKLR CCEEEEEEECCHHHH	18.25	-
88	Phosphorylation	TDMDDAATALREAQE CCHHHHHHHHHHHHH	28.13	-
151	Phosphorylation	VFLVPLAYFLHPQVH EEEEEEHHHHCCCCC	17.85	-
164	Phosphorylation	VHDQHYVTRLGHRFI CCCHHHHHHHHHHHH	17.01	-
185	Phosphorylation	TNPEDGVTYQIKGMT CCCCCCCEEEECCHH	18.42	22468782
186	Phosphorylation	NPEDGVTYQIKGMTA CCCCCCEEEECCHHH	13.06	22468782

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUDT7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUDT7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUDT7_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NUDT7_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.