DNSL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DNSL2_HUMAN
• UniProt AC: Q92874
• Protein Name: Deoxyribonuclease-1-like 2
• Gene Name: DNASE1L2
• Organism: Homo sapiens (Human).
• Sequence Length: 299
• Subcellular Localization: Cytoplasm . Secreted .
• Protein Description: Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells..
• Protein Sequence: MGGPRALLAALWALEAAGTAALRIGAFNIQSFGDSKVSDPACGSIIAKILAGYDLALVQEVRDPDLSAVSALMEQINSVSEHEYSFVSSQPLGRDQYKEMYLFVYRKDAVSVVDTYLYPDPEDVFSREPFVVKFSAPGTGERAPPLPSRRALTPPPLPAAAQNLVLIPLHAAPHQAVAEIDALYDVYLDVIDKWGTDDMLFLGDFNADCSYVRAQDWAAIRLRSSEVFKWLIPDSADTTVGNSDCAYDRIVACGARLRRSLKPQSATVHDFQEEFGLDQTQALAISDHFPVEVTLKFHR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	IGAFNIQSFGDSKVS CCCEEEECCCCCCCC	27.65	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DNSL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DNSL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DNSL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TCPW_HUMAN	CCT6B	physical	26186194
RL23_HUMAN	RPL23	physical	26186194
CSK_HUMAN	CSK	physical	26186194
INSR_HUMAN	INSR	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.