CO2A1_HUMAN - dbPTM
CO2A1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CO2A1_HUMAN
UniProt AC P02458
Protein Name Collagen alpha-1(II) chain {ECO:0000305}
Gene Name COL2A1 {ECO:0000312|HGNC:HGNC:2200}
Organism Homo sapiens (Human).
Sequence Length 1487
Subcellular Localization Secreted, extracellular space, extracellular matrix .
Protein Description Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces..
Protein Sequence MIRLGAPQTLVLLTLLVAAVLRCQGQDVQEAGSCVQDGQRYNDKDVWKPEPCRICVCDTGTVLCDDIICEDVKDCLSPEIPFGECCPICPTDLATASGQPGPKGQKGEPGDIKDIVGPKGPPGPQGPAGEQGPRGDRGDKGEKGAPGPRGRDGEPGTPGNPGPPGPPGPPGPPGLGGNFAAQMAGGFDEKAGGAQLGVMQGPMGPMGPRGPPGPAGAPGPQGFQGNPGEPGEPGVSGPMGPRGPPGPPGKPGDDGEAGKPGKAGERGPPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKGEAGAPGVKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGARGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAGPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGARGQPGVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGERGEQGAPGPSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPGAQGLQGPRGLPGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETGPPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGRAGEPGLQGPAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPGPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPGERGLKGHRGFTGLQGLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGIPGPIGPPGPRGRSGETGPAGPPGNPGPPGPPGPPGPGIDMSAFAGLGPREKGPDPLQYMRADQAAGGLRQHDAEVDATLKSLNNQIESIRSPEGSRKNPARTCRDLKLCHPEWKSGDYWIDPNQGCTLDAMKVFCNMETGETCVYPNPANVPKKNWWSSKSKEKKHIWFGETINGGFHFSYGDDNLAPNTANVQMTFLRLLSTEGSQNITYHCKNSIAYLDEAAGNLKKALLIQGSNDVEIRAEGNSRFTYTALKDGCTKHTGKWGKTVIEYRSQKTSRLPIIDIAPMDIGGPEQEFGVDIGPVCFL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
41PhosphorylationCVQDGQRYNDKDVWK
CCCCCCCCCCCCCCC		21.59-
74UbiquitinationIICEDVKDCLSPEIP
HHCCCHHHHCCCCCC		38.1427667366
121UbiquitinationDIVGPKGPPGPQGPA
HCCCCCCCCCCCCCC		36.4827667366
143UbiquitinationDRGDKGEKGAPGPRG
CCCCCCCCCCCCCCC		69.8727667366
190O-linked_GlycosylationMAGGFDEKAGGAQLG
HCCCCCCCCCCCEEE		54.93-
190UbiquitinationMAGGFDEKAGGAQLG
HCCCCCCCCCCCEEE		54.9327667366
190HydroxylationMAGGFDEKAGGAQLG
HCCCCCCCCCCCEEE		54.93-
191UbiquitinationAGGFDEKAGGAQLGV
CCCCCCCCCCCEEEE		21.4327667366
287O-linked_GlycosylationTPGLPGVKGHRGYPG
CCCCCCCCCCCCCCC		55.72-
287HydroxylationTPGLPGVKGHRGYPG
CCCCCCCCCCCCCCC		55.72-
299HydroxylationYPGLDGAKGEAGAPG
CCCCCCCCCCCCCCC		63.91-
299O-linked_GlycosylationYPGLDGAKGEAGAPG
CCCCCCCCCCCCCCC		63.91-
308HydroxylationEAGAPGVKGESGSPG
CCCCCCCCCCCCCCC		63.98-
308O-linked_GlycosylationEAGAPGVKGESGSPG
CCCCCCCCCCCCCCC		63.98-
374HydroxylationFPGAPGAKGEAGPTG
CCCCCCCCCCCCCCC		64.30-
374O-linked_GlycosylationFPGAPGAKGEAGPTG
CCCCCCCCCCCCCCC		64.30-
536PhosphorylationAPGERGPSGLAGPKG
CCCCCCCCCCCCCCC		49.62-
542AcetylationPSGLAGPKGANGDPG
CCCCCCCCCCCCCCC		70.50158689
608HydroxylationVMGFPGPKGANGEPG
CCCCCCCCCCCCCCC		76.27-
608O-linked_GlycosylationVMGFPGPKGANGEPG
CCCCCCCCCCCCCCC		76.27-
620O-linked_GlycosylationEPGKAGEKGLPGAPG
CCCCCCCCCCCCCCC		65.90-
620HydroxylationEPGKAGEKGLPGAPG
CCCCCCCCCCCCCCC		65.90-
659HydroxylationERGEQGAPGPSGFQG
CCCCCCCCCCCCCCC		63.15-
668HydroxylationPSGFQGLPGPPGPPG
CCCCCCCCCCCCCCC		61.13-
670HydroxylationGFQGLPGPPGPPGEG
CCCCCCCCCCCCCCC		28.83-
671HydroxylationFQGLPGPPGPPGEGG
CCCCCCCCCCCCCCC		74.06-
674HydroxylationLPGPPGPPGEGGKPG
CCCCCCCCCCCCCCC		60.42-
764AcetylationAAGIAGPKGDRGDVG
CCCCCCCCCCCCCCC		72.95164033
773AcetylationDRGDVGEKGPEGAPG
CCCCCCCCCCCCCCC		74.0619809335
907HydroxylationGAAGRVGPPGSNGNP
CCCCCCCCCCCCCCC		27.50-
908HydroxylationAAGRVGPPGSNGNPG
CCCCCCCCCCCCCCC		53.57-
914HydroxylationPPGSNGNPGPPGPPG
CCCCCCCCCCCCCCC		59.05-
920HydroxylationNPGPPGPPGPSGKDG
CCCCCCCCCCCCCCC		73.56-
1061PhosphorylationVKGDRGETGAVGAPG
CCCCCCCCCCCCCCC		33.0124667141
1130HydroxylationEPGERGLKGHRGFTG
CCCCCCCCCCCCCCC		56.34-
1130O-linked_GlycosylationEPGERGLKGHRGFTG
CCCCCCCCCCCCCCC		56.34-
1144HydroxylationGLQGLPGPPGPSGDQ
CCCCCCCCCCCCCCC		28.83-
1181HydroxylationKDGANGIPGPIGPPG
CCCCCCCCCCCCCCC		43.86-
1186HydroxylationGIPGPIGPPGPRGRS
CCCCCCCCCCCCCCC		31.24-
1187HydroxylationIPGPIGPPGPRGRSG
CCCCCCCCCCCCCCC		61.27-
1201HydroxylationGETGPAGPPGNPGPP
CCCCCCCCCCCCCCC		35.41-
1202HydroxylationETGPAGPPGNPGPPG
CCCCCCCCCCCCCCC		55.03-
1205HydroxylationPAGPPGNPGPPGPPG
CCCCCCCCCCCCCCC		63.68-
1207HydroxylationGPPGNPGPPGPPGPP
CCCCCCCCCCCCCCC		31.75-
1208HydroxylationPPGNPGPPGPPGPPG
CCCCCCCCCCCCCCC		74.06-
1211HydroxylationNPGPPGPPGPPGPGI
CCCCCCCCCCCCCCC		74.06-
1213HydroxylationGPPGPPGPPGPGIDM
CCCCCCCCCCCCCCH		36.13-
1214HydroxylationPPGPPGPPGPGIDMS
CCCCCCCCCCCCCHH		68.47-
1307PhosphorylationIDPNQGCTLDAMKVF
ECCCCCCCHHHEEEH		34.20-
1388N-linked_GlycosylationLSTEGSQNITYHCKN
HCCCCCCCEEEEECC		30.21UniProtKB CARBOHYD
1416PhosphorylationKALLIQGSNDVEIRA
HEEEECCCCCEEEEE		17.30-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CO2A1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CO2A1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CO2A1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BMP2_HUMANBMP2physical
10085302
ANXA5_HUMANANXA5physical
1397263
PDGFA_HUMANPDGFAphysical
8900172
PDGFB_HUMANPDGFBphysical
8900172
HYAL1_HUMANHYAL1physical
21988832
TF65_HUMANRELAphysical
21988832
PLOD1_HUMANPLOD1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
183900Spondyloepiphyseal dysplasia congenital type (SEDC)
184250Spondyloepimetaphyseal dysplasia, Strudwick type (SEMDSTWK)
200610Achondrogenesis 2 (ACG2)
150600Legg-Calve-Perthes disease (LCPD)
156550Kniest dysplasia (KD)
608805Primary avascular necrosis of femoral head (ANFH)
604864Osteoarthritis with mild chondrodysplasia (OACD)
151210Platyspondylic lethal skeletal dysplasia Torrance type (PLSD-T)
132450Multiple epiphyseal dysplasia with myopia and conductive deafness (EDMMD)
271700Spondyloperipheral dysplasia (SPD)
108300Stickler syndrome 1 (STL1)
609508Stickler syndrome 1 non-syndromic ocular (STL1O)
609508Rhegmatogenous retinal detachment autosomal dominant (DRRD)
609162Czech dysplasia (CZECHD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CO2A1_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory