HYAL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HYAL1_HUMAN
• UniProt AC: Q12794
• Protein Name: Hyaluronidase-1
• Gene Name: HYAL1
• Organism: Homo sapiens (Human).
• Sequence Length: 435
• Subcellular Localization: Secreted . Lysosome .
• Protein Description: May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth..
• Protein Sequence: MAAHLLPICALFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVANPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAPDFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAARAWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSRALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPLDELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLCSQALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRCYPGWQAPWCERKSMW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
99	N-linked_Glycosylation	VFGGLPQNASLIAHL CCCCCCCCHHHHHHH	29.56	17503783
144	Ubiquitination	WAFNWDTKDIYRQRS ECCCCCHHHHHHHHH	39.39	-
216	N-linked_Glycosylation	NYDFLSPNYTGQCPS CCCCCCCCCCCCCCC	43.55	17503783
261	Phosphorylation	GTGKSQMYVQHRVAE CCCCCHHHHHHHHHH	6.85	-
350	N-linked_Glycosylation	TLGPFILNVTSGALL CCHHHHEEECCHHHH	30.15	17503783

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HYAL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HYAL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HYAL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBR2_HUMAN	UBR2	physical	28514442
UBR4_HUMAN	UBR4	physical	28514442
RN123_HUMAN	RNF123	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
UBAC1_HUMAN	UBAC1	physical	28514442
TBA1B_HUMAN	TUBA1B	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 601492: Mucopolysaccharidosis 9 (MPS9)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzymeinvolved in tumor growth and angiogenesis.";
Chao K.L., Muthukumar L., Herzberg O.;
Biochemistry 46:6911-6920(2007).
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 20-435; MASS SPECTROMETRY,GLYCOSYLATION AT ASN-99; ASN-216 AND ASN-350, AND DISULFIDE BONDS.
PubMed: 17503783