BMP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BMP2_HUMAN
• UniProt AC: P12643
• Protein Name: Bone morphogenetic protein 2
• Gene Name: BMP2
• Organism: Homo sapiens (Human).
• Sequence Length: 396
• Subcellular Localization: Secreted.
• Protein Description: Induces cartilage and bone formation. [PubMed: 3201241 Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4]
• Protein Sequence: MVAGTRCLLALLLPQVLLGGAAGLVPELGRRKFAAASSGRPSSQPSDEVLSEFELRLLSMFGLKQRPTPSRDAVVPPYMLDLYRRHSGQPGSPAPDHRLERAASRANTVRSFHHEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHKREKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
87	Phosphorylation	LDLYRRHSGQPGSPA HHHHHHHCCCCCCCC	36.99	-
111	Phosphorylation	SRANTVRSFHHEESL HHHHHHHHHCCHHHH	25.29	23312004
117	Phosphorylation	RSFHHEESLEELPET HHHCCHHHHHHCCCC	37.79	26657352
135	N-linked_Glycosylation	TTRRFFFNLSSIPTE CEEEEEEECCCCCHH	33.58	UniProtKB CARBOHYD
163	N-linked_Glycosylation	QMQDALGNNSSFHHR HHHHHHCCCCCCCCC	46.16	UniProtKB CARBOHYD
164	N-linked_Glycosylation	MQDALGNNSSFHHRI HHHHHCCCCCCCCCE	36.91	UniProtKB CARBOHYD
181	Phosphorylation	YEIIKPATANSKFPV HHEECCCCCCCCCCC	34.59	-
184	Phosphorylation	IKPATANSKFPVTRL ECCCCCCCCCCCCHH	32.96	-
200	N-linked_Glycosylation	DTRLVNQNASRWESF CHHCCCCCCCCCCCC	34.38	UniProtKB CARBOHYD
200	N-linked_Glycosylation	DTRLVNQNASRWESF CHHCCCCCCCCCCCC	34.38	20068230
278	Ubiquitination	GKGHPLHKREKRQAK CCCCCCCHHHHHHHH	70.68	-
338	N-linked_Glycosylation	FPLADHLNSTNHAIV CCCHHHHCCCCHHHH	43.28	9265423
383	Ubiquitination	ENEKVVLKNYQDMVV CCCCEEEECHHHHEE	41.84	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BMP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BMP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BMP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BMPR2_HUMAN	BMPR2	physical	7791754
CO2A1_HUMAN	COL2A1	physical	10085302
BMR1A_HUMAN	BMPR1A	physical	10692589
BMR1A_HUMAN	BMPR1A	physical	10880444
BMPR2_HUMAN	BMPR2	physical	10880444
ARP2_HUMAN	ACTR2	physical	10880444
MGP_HUMAN	MGP	physical	11741887
BMR1A_HUMAN	BMPR1A	physical	10712517
BMR1B_HUMAN	BMPR1B	physical	10712517
BMPR2_HUMAN	BMPR2	physical	10712517

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.