| UniProt ID | MGP_HUMAN | |
|---|---|---|
| UniProt AC | P08493 | |
| Protein Name | Matrix Gla protein | |
| Gene Name | MGP | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 103 | |
| Subcellular Localization | Secreted. | |
| Protein Description | Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.. | |
| Protein Sequence | MKSLILLAILAALAVVTLCYESHESMESYELNPFINRRNANTFISPQQRWRAKVQERIRERSKPVHELNREACDDYRLCERYAMVYGYNAAYNRYFRKRRGTK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 21 | 4-carboxyglutamate | AVVTLCYESHESMES HHHHHHHHCCHHHHH | 44.62 | - | |
| 21 | Gamma-carboxyglutamic_acid | AVVTLCYESHESMES HHHHHHHHCCHHHHH | 44.62 | - | |
| 22 | Phosphorylation | VVTLCYESHESMESY HHHHHHHCCHHHHHH | 13.18 | 22817900 | |
| 25 | Phosphorylation | LCYESHESMESYELN HHHHCCHHHHHHCCC | 23.56 | 22817900 | |
| 28 | Phosphorylation | ESHESMESYELNPFI HCCHHHHHHCCCCCC | 18.44 | 22817900 | |
| 56 | 4-carboxyglutamate | RWRAKVQERIRERSK HHHHHHHHHHHHHCC | 53.73 | - | |
| 56 | Gamma-carboxyglutamic_acid | RWRAKVQERIRERSK HHHHHHHHHHHHHCC | 53.73 | - | |
| 60 | 4-carboxyglutamate | KVQERIRERSKPVHE HHHHHHHHHCCCHHH | 59.96 | - | |
| 60 | Gamma-carboxyglutamic_acid | KVQERIRERSKPVHE HHHHHHHHHCCCHHH | 59.96 | - | |
| 67 | 4-carboxyglutamate | ERSKPVHELNREACD HHCCCHHHHCHHHHH | 48.23 | - | |
| 67 | Gamma-carboxyglutamic_acid | ERSKPVHELNREACD HHCCCHHHHCHHHHH | 48.23 | - | |
| 71 | 4-carboxyglutamate | PVHELNREACDDYRL CHHHHCHHHHHHHHH | 53.21 | - | |
| 71 | Gamma-carboxyglutamic_acid | PVHELNREACDDYRL CHHHHCHHHHHHHHH | 53.21 | - | |
| 82 | Phosphorylation | DYRLCERYAMVYGYN HHHHHHHHHHHHCHH | 4.09 | 22817900 | |
| 92 | Phosphorylation | VYGYNAAYNRYFRKR HHCHHHHHHHHHHHH | 9.58 | - | |
| 107 | Phosphorylation | RGTK----------- CCCC----------- | 27251275 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MGP_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MGP_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MGP_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MGP_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 245150 | Keutel syndrome (KTLS) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "Conserved phosphorylation of serines in the Ser-X-Glu/Ser(P)sequences of the vitamin K-dependent matrix Gla protein from shark,lamb, rat, cow, and human."; Price P.A., Rice J.S., Williamson M.K.; Protein Sci. 3:822-830(1994). Cited for: PHOSPHORYLATION AT SER-22; SER-25 AND SER-28. | |
