SPCS3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPCS3_HUMAN
• UniProt AC: P61009
• Protein Name: Signal peptidase complex subunit 3
• Gene Name: SPCS3
• Organism: Homo sapiens (Human).
• Sequence Length: 180
• Subcellular Localization: Microsome membrane ; Single-pass type II membrane protein . Endoplasmic reticulum membrane ; Single-pass type II membrane protein .
• Protein Description: Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum..
• Protein Sequence: MNTVLSRANSLFAFSLSVMAALTFGCFITTAFKDRSVPVRLHVSRIMLKNVEDFTGPRERSDLGFITFDITADLENIFDWNVKQLFLYLSAEYSTKNNALNQVVLWDKIVLRGDNPKLLLKDMKTKYFFFDDGNGLKGNRNVTLTLSWNVVPNAGILPLVTGSGHVSVPFPDTYEITKSY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MNTVLSRANS -----CCCHHHHHHH	22.86	24043423
6	Phosphorylation	--MNTVLSRANSLFA --CCCHHHHHHHHHH	25.63	24043423
10	Phosphorylation	TVLSRANSLFAFSLS CHHHHHHHHHHHHHH	24.71	24043423
15	Phosphorylation	ANSLFAFSLSVMAAL HHHHHHHHHHHHHHH	19.12	24043423
17	Phosphorylation	SLFAFSLSVMAALTF HHHHHHHHHHHHHHH	14.51	24043423
23	Phosphorylation	LSVMAALTFGCFITT HHHHHHHHHCHHHHH	17.16	24043423
29	Phosphorylation	LTFGCFITTAFKDRS HHHCHHHHHHCCCCC	7.57	24043423
30	Phosphorylation	TFGCFITTAFKDRSV HHCHHHHHHCCCCCC	25.86	24043423
49	Ubiquitination	HVSRIMLKNVEDFTG EEEEEEECCHHHCCC	41.38	27667366
49	Acetylation	HVSRIMLKNVEDFTG EEEEEEECCHHHCCC	41.38	27452117
49	2-Hydroxyisobutyrylation	HVSRIMLKNVEDFTG EEEEEEECCHHHCCC	41.38	-
55	Phosphorylation	LKNVEDFTGPRERSD ECCHHHCCCCCCCCC	59.61	24719451
71	Phosphorylation	GFITFDITADLENIF CEEEEEEECCHHHHC	18.90	-
108	Ubiquitination	NQVVLWDKIVLRGDN CCEEEEEEEEECCCC	24.11	22817900
117	Ubiquitination	VLRGDNPKLLLKDMK EECCCCCCEEEECCC	59.00	22817900
121	Ubiquitination	DNPKLLLKDMKTKYF CCCCEEEECCCCCEE	56.60	22817900
121	2-Hydroxyisobutyrylation	DNPKLLLKDMKTKYF CCCCEEEECCCCCEE	56.60	-
124	Ubiquitination	KLLLKDMKTKYFFFD CEEEECCCCCEEEEE	52.58	22817900
125	Phosphorylation	LLLKDMKTKYFFFDD EEEECCCCCEEEEEC	25.08	27174698
126	Ubiquitination	LLKDMKTKYFFFDDG EEECCCCCEEEEECC	34.24	21906983
126	2-Hydroxyisobutyrylation	LLKDMKTKYFFFDDG EEECCCCCEEEEECC	34.24	-
126	Acetylation	LLKDMKTKYFFFDDG EEECCCCCEEEEECC	34.24	27452117
127	Phosphorylation	LKDMKTKYFFFDDGN EECCCCCEEEEECCC	15.73	25693802
137	Ubiquitination	FDDGNGLKGNRNVTL EECCCCCCCCCEEEE	56.38	27667366
141	N-linked_Glycosylation	NGLKGNRNVTLTLSW CCCCCCCEEEEEEEE	34.82	19159218

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPCS3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPCS3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPCS3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SPCS3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-141, AND MASSSPECTROMETRY.
PubMed: 19159218