C2D2A_HUMAN - dbPTM
C2D2A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID C2D2A_HUMAN
UniProt AC Q9P2K1
Protein Name Coiled-coil and C2 domain-containing protein 2A
Gene Name CC2D2A
Organism Homo sapiens (Human).
Sequence Length 1620
Subcellular Localization Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Localizes at the transition zone, a region between the basal body and the ciliary axoneme..
Protein Description Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity)..
Protein Sequence MNPREEKVKIITEEFIENDEDADMGRQNKNSKVRRQPRKKQPPTAVPKEMVSEKSHLGNPQEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALLQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMDEEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRLQMEREMLFIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGRILALPNPIKPFPSRPPVLTQEQSIKAELETLYKKAVKYVHSSQHVIRSGDPPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELSLAGSVTPNDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRPLGADFRVHFGQIFNLQIVNWPESLTLQVYETVGHSSPTLLAEVFLPIPETTVVTGRAPTEEVEFSSNQHVTLDHEGVGSGVPFSFEADGSNQLTLMTSGKVSHSVAWAIGENGIPLIPPLSQQNIGFRSALKKADAISSIGTSGLTDMKKLAKWAAESKLDPNDPNNAPLMQLISVATSGESYVPDFFRLEQLQQEFNFVSDQELNRSKRFRLLHLRSQEVPEFRNYKQVPVYDREIMEKVFQDYEKRLRDRNVIETKEHIDTHRAIVAKYLQQVRESVINRFLIAKQYFLLADMIVEEEVPNISILGLSLFKLAEQKRPLRPRRKGRKKVTAQNLSDGDIKLLVNIVRAYDIPVRKPAVSKFQQPSRSSRMFSEKHAASPSTYSPTHNADYPLGQVLVRPFVEVSFQRTVCHTTTAEGPNPSWNEELELPFRAPNGDYSTASLQSVKDVVFINIFDEVLHDVLEDDRERGSGIHTRIERHWLGCVKMPFSTIYFQARIDGTFKIDIPPVLLGYSKERNMILERGFDSVRSLSEGSYITLFITIEPQLVPGESIREKFESQEDEKLLQATEKFQAECALKFPNRQCLTTVIDISGKTVFITRYLKPLNPPQELLNVYPNNLQATAELVARYVSLIPFLPDTVSFGGICDLWSTSDQFLDLLAGDEEEHAVLLCNYFLSLGKKAWLLMGNAIPEGPTAYVLTWEQGRYLIWNPCSGHFYGQFDTFCPLKNVGCLIGPDNIWFNIQRYESPLRINFDVTRPKLWKSFFSRSLPYPGLSSVQPEELIYQRSDKAAAAELQDRIEKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLEKSQGEDVEDDHRAELLKQLGDYRFSGFPLHMPYSEVKPLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLSVWIYVASLIRNR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationEEKVKIITEEFIEND
HHHCEEEEHHHHHCC		32.70-
76O-linked_GlycosylationKTRLLSMTVRRGPRS
CCHHHHCEECCCCCC		13.9030379171
93PhosphorylationPIPSTSRTGFAEFSM
CCCCCCCCCCEECHH		36.10-
99PhosphorylationRTGFAEFSMRGRMRE
CCCCEECHHHHHHHH		10.08-
101MethylationGFAEFSMRGRMREKL
CCEECHHHHHHHHHH		28.50-
125PhosphorylationALLQEIPTPRPRRLR
HHHHCCCCCCCCCCC		37.2828060719
133PhosphorylationPRPRRLRSPSKKELE
CCCCCCCCCCHHHHH		37.8127067055
163PhosphorylationQEVDSQSYSRVKFHD
HHCHHCCCCEEEECC		7.89-
167UbiquitinationSQSYSRVKFHDSARK
HCCCCEEEECCCCCC		35.5529967540
206PhosphorylationFDPEPEGSEEKPKAR
CCCCCCCCCCCCCHH		40.7024719451
218PhosphorylationKARHRAGTNQEEEEG
CHHCCCCCCCHHHCC		32.5126133373
299UbiquitinationQTVPTYKKLPENVQP
CCCCCCCCCCCCCCC		59.8829967540
315PhosphorylationFLEDEGLYTGVRPEV
CCCCCCCCCCCCHHH		16.5920886841
316PhosphorylationLEDEGLYTGVRPEVA
CCCCCCCCCCCHHHH		33.9520886841
381PhosphorylationKAELETLYKKAVKYV
HHHHHHHHHHHHHHH		20.1924114839
382UbiquitinationAELETLYKKAVKYVH
HHHHHHHHHHHHHHH		37.0529967540
469UbiquitinationQTGLDPEKPHQSLDT
HCCCCCCCCCCCHHH		53.8629967540
473PhosphorylationDPEKPHQSLDTIQKT
CCCCCCCCHHHHHHH		25.7728555341
618UbiquitinationYPEEDLVKPSPPEPT
CCHHHCCCCCCCCCC		47.2629967540
681PhosphorylationREDVKKRSVYLKVLF
HHHHHHHEEEEEHHC		24.8023909892
683PhosphorylationDVKKRSVYLKVLFNN
HHHHHEEEEEHHCCC		11.3123909892
849UbiquitinationTSGLTDMKKLAKWAA
CCCHHHHHHHHHHHH		47.6629967540
879UbiquitinationQLISVATSGESYVPD
HHHHHHHCCCCCCCC		30.7227667366
928UbiquitinationVPEFRNYKQVPVYDR
CCCCCCCCCCCCCCH		48.6627667366
940UbiquitinationYDREIMEKVFQDYEK
CCHHHHHHHHHHHHH		30.8529967540
945PhosphorylationMEKVFQDYEKRLRDR
HHHHHHHHHHHHHHC		16.7420049867
947UbiquitinationKVFQDYEKRLRDRNV
HHHHHHHHHHHHCCC		50.9729967540
958UbiquitinationDRNVIETKEHIDTHR
HCCCCCCHHHHHHHH		34.2129967540
1010PhosphorylationNISILGLSLFKLAEQ
CCEEHHHHHHHHHHC		29.9324719451
1030UbiquitinationPRRKGRKKVTAQNLS
CCCCCCCCCCCCCCC		43.3829967540
1037O-linked_GlycosylationKVTAQNLSDGDIKLL
CCCCCCCCCCCHHHH		47.2830379171
1062UbiquitinationVRKPAVSKFQQPSRS
CCCCCCCCCCCCCHH		40.3629967540
1080PhosphorylationFSEKHAASPSTYSPT
CCCCCCCCCCCCCCC		21.8427732954
1082PhosphorylationEKHAASPSTYSPTHN
CCCCCCCCCCCCCCC		37.1727732954
1083PhosphorylationKHAASPSTYSPTHNA
CCCCCCCCCCCCCCC		31.2527732954
1084PhosphorylationHAASPSTYSPTHNAD
CCCCCCCCCCCCCCC		19.5927732954
1085PhosphorylationAASPSTYSPTHNADY
CCCCCCCCCCCCCCC		24.3427732954
1087PhosphorylationSPSTYSPTHNADYPL
CCCCCCCCCCCCCCC		23.0927732954
1176PhosphorylationERGSGIHTRIERHWL
HHCCCCCHHHHHHHC		31.2727174698
1216UbiquitinationPVLLGYSKERNMILE
CEECCCCHHHCCHHH		52.8121906983
1216 (in isoform 4)Ubiquitination-52.8121906983
1265UbiquitinationFESQEDEKLLQATEK
HHCHHHHHHHHHHHH		67.8129967540
1382 (in isoform 2)Ubiquitination-42.8921906983
1401PhosphorylationGPTAYVLTWEQGRYL
CCCEEEEEECCCCEE		19.53-
1469PhosphorylationWKSFFSRSLPYPGLS
HHHHHHCCCCCCCCC		32.28-
1490 (in isoform 4)Ubiquitination-40.9721906983
1490UbiquitinationLIYQRSDKAAAAELQ
HHHHCCCHHHHHHHH		40.9733845483
1552UbiquitinationDHRAELLKQLGDYRF
HHHHHHHHHHCCCCC		56.9829967540
1572AcetylationHMPYSEVKPLIDAVY
CCCHHHHHHHHHHHH		30.0119813619
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of C2D2A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of C2D2A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of C2D2A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
OFD1_HUMANOFD1physical
26638075
PCM1_HUMANPCM1physical
26638075
AHI1_HUMANAHI1physical
26638075
ASCC2_HUMANASCC2physical
26638075
ASCC3_HUMANASCC3physical
26638075
CP131_HUMANCEP131physical
26638075
B9D1_HUMANB9D1physical
26638075
B9D2_HUMANB9D2physical
26638075
DVL3_HUMANDVL3physical
26638075
ECH1_HUMANECH1physical
26638075
GPTC1_HUMANGPATCH1physical
26638075
HAUS8_HUMANHAUS8physical
26638075
LMNA_HUMANLMNAphysical
26638075
M21D2_HUMANMB21D2physical
26638075
MKS1_HUMANMKS1physical
26638075
NOLC1_HUMANNOLC1physical
26638075
NOP2_HUMANNOP2physical
26638075
RPF2_HUMANRPF2physical
26638075
SRP72_HUMANSRP72physical
26638075
SRP09_HUMANSRP9physical
26638075
STALP_HUMANSTAMBPL1physical
26638075
STAU1_HUMANSTAU1physical
26638075
TECT3_HUMANTCTN3physical
26638075
TDRD3_HUMANTDRD3physical
26638075
TRI26_HUMANTRIM26physical
26638075
UN45A_HUMANUNC45Aphysical
26638075
WDR55_HUMANWDR55physical
26638075
WDR83_HUMANWDR83physical
26638075
XRN1_HUMANXRN1physical
26638075
YTDC2_HUMANYTHDC2physical
26638075
1433F_HUMANYWHAHphysical
26638075
ZC3HF_HUMANZC3H15physical
26638075
CC138_HUMANCCDC138physical
26638075
ADIP_HUMANSSX2IPphysical
26638075
NH2L1_HUMANNHP2L1physical
26638075
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
612284Meckel syndrome 6 (MKS6)
612285Joubert syndrome 9 (JBTS9)
216360COACH syndrome (COACHS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of C2D2A_HUMAN

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Related Literatures of Post-Translational Modification

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