dbPTM

TECT3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TECT3_HUMAN
UniProt AC	Q6NUS6
Protein Name	Tectonic-3
Gene Name	TCTN3
Organism	Homo sapiens (Human).
Sequence Length	607
Subcellular Localization	Membrane Single-pass type I membrane protein .
Protein Description	Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). May be involved in apoptosis regulation. Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway..
Protein Sequence	MRTPQLALLQVFFLVFPDGVRPQPSSSPSGAVPTSLELQRGTDGGTLQSPSEATATRPAVPGLPTVVPTLVTPSAPGNRTVDLFPVLPICVCDLTPGACDINCCCDRDCYLLHPRTVFSFCLPGSVRSSSWVCVDNSVIFRSNSPFPSRVFMDSNGIRQFCVHVNNSNLNYFQKLQKVNATNFQALAAEFGGESFTSTFQTQSPPSFYRAGDPILTYFPKWSVISLLRQPAGVGAGGLCAESNPAGFLESKSTTCTRFFKNLASSCTLDSALNAASYYNFTVLKVPRSMTDPQNMEFQVPVILTSQANAPLLAGNTCQNVVSQVTYEIETNGTFGIQKVSVSLGQTNLTVEPGASLQQHFILRFRAFQQSTAASLTSPRSGNPGYIVGKPLLALTDDISYSMTLLQSQGNGSCSVKRHEVQFGVNAISGCKLRLKKADCSHLQQEIYQTLHGRPRPEYVAIFGNADPAQKGGWTRILNRHCSISAINCTSCCLIPVSLEIQVLWAYVGLLSNPQAHVSGVRFLYQCQSIQDSQQVTEVSLTTLVNFVDITQKPQPPRGQPKMDWKWPFDFFPFKVAFSRGVFSQKCSVSPILILCLLLLGVLNLETM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
78	N-linked_Glycosylation	VTPSAPGNRTVDLFP ECCCCCCCCEECCCC	35.08	UniProtKB CARBOHYD
148	Phosphorylation	RSNSPFPSRVFMDSN CCCCCCCCCEEECCC	41.26	25072903
154	Phosphorylation	PSRVFMDSNGIRQFC CCCEEECCCCCEEEE	25.76	25072903
171 (in isoform 5)	Phosphorylation	-	15.56	30631047
179	N-linked_Glycosylation	FQKLQKVNATNFQAL HHHHHHCCCCCHHHH	48.35	UniProtKB CARBOHYD
181	Phosphorylation	KLQKVNATNFQALAA HHHHCCCCCHHHHHH	31.21	-
196	O-linked_Glycosylation	EFGGESFTSTFQTQS HHCCCCCCEEEECCC	35.82	OGP
201	O-linked_Glycosylation	SFTSTFQTQSPPSFY CCCEEEECCCCCCCC	27.16	OGP
220	Ubiquitination	PILTYFPKWSVISLL CEECCCCCCHHHHHH	42.05	33845483
251	Ubiquitination	PAGFLESKSTTCTRF CCCCCCCCCHHHHHH	42.31	27667366
269	Ubiquitination	LASSCTLDSALNAAS HHHCCCHHHHHHHHH	17.45	27667366
288	Ubiquitination	TVLKVPRSMTDPQNM EEEECCCCCCCCCCC	21.69	29967540
347	N-linked_Glycosylation	SVSLGQTNLTVEPGA EEEECCCEEEECCCC	26.31	UniProtKB CARBOHYD
370	O-linked_Glycosylation	RFRAFQQSTAASLTS HHHHHHCCCCCCCCC	14.83	OGP
371	O-linked_Glycosylation	FRAFQQSTAASLTSP HHHHHCCCCCCCCCC	23.16	OGP
374	O-linked_Glycosylation	FQQSTAASLTSPRSG HHCCCCCCCCCCCCC	29.71	OGP
377	O-linked_Glycosylation	STAASLTSPRSGNPG CCCCCCCCCCCCCCC	24.49	OGP
436	Ubiquitination	GCKLRLKKADCSHLQ CCEEEECCCCCHHHH	54.79	29967540
541	O-linked_Glycosylation	QVTEVSLTTLVNFVD CEEEEEEEEEEEHHC	15.58	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TECT3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TECT3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TECT3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TGM1_HUMAN	TGM1	physical	26186194
CATH_HUMAN	CTSH	physical	26186194
SPA12_HUMAN	SERPINA12	physical	26186194
CYTA_HUMAN	CSTA	physical	26186194
CBPA4_HUMAN	CPA4	physical	26186194
KPRP_HUMAN	KPRP	physical	26186194
AAAS_HUMAN	AAAS	physical	26638075
ABCBA_HUMAN	ABCB10	physical	26638075
ABD12_HUMAN	ABHD12	physical	26638075
ACDSB_HUMAN	ACADSB	physical	26638075
ACSL3_HUMAN	ACSL3	physical	26638075
PAQR2_HUMAN	ADIPOR2	physical	26638075
GPAT4_HUMAN	AGPAT6	physical	26638075
GPAT3_HUMAN	AGPAT9	physical	26638075
AL1B1_HUMAN	ALDH1B1	physical	26638075
AL3A2_HUMAN	ALDH3A2	physical	26638075
ALG3_HUMAN	ALG3	physical	26638075
ALG6_HUMAN	ALG6	physical	26638075
ALG9_HUMAN	ALG9	physical	26638075
ANKL2_HUMAN	ANKLE2	physical	26638075
ANO6_HUMAN	ANO6	physical	26638075
APOL2_HUMAN	APOL2	physical	26638075
PRAF3_HUMAN	ARL6IP5	physical	26638075
AT131_HUMAN	ATP13A1	physical	26638075
AT1A1_HUMAN	ATP1A1	physical	26638075
AT2A2_HUMAN	ATP2A2	physical	26638075
VAS1_HUMAN	ATP6AP1	physical	26638075
RENR_HUMAN	ATP6AP2	physical	26638075
VPP1_HUMAN	ATP6V0A1	physical	26638075
VPP2_HUMAN	ATP6V0A2	physical	26638075
VATL_HUMAN	ATP6V0C	physical	26638075
VATF_HUMAN	ATP6V1F	physical	26638075
AUP1_HUMAN	AUP1	physical	26638075
BAP31_HUMAN	BCAP31	physical	26638075
BET1_HUMAN	BET1	physical	26638075
BRI3B_HUMAN	BRI3BP	physical	26638075
EMC7_HUMAN	EMC7	physical	26638075
EMC10_HUMAN	EMC10	physical	26638075
C1QBP_HUMAN	C1QBP	physical	26638075
CALR_HUMAN	CALR	physical	26638075
CAMLG_HUMAN	CAMLG	physical	26638075
CALX_HUMAN	CANX	physical	26638075
CC115_HUMAN	CCDC115	physical	26638075
CCD47_HUMAN	CCDC47	physical	26638075
CDKAL_HUMAN	CDKAL1	physical	26638075
CDS2_HUMAN	CDS2	physical	26638075
CERS1_HUMAN	CERS1	physical	26638075
CERS2_HUMAN	CERS2	physical	26638075
CISD2_HUMAN	CISD2	physical	26638075
CKAP4_HUMAN	CKAP4	physical	26638075
CLCC1_HUMAN	CLCC1	physical	26638075
CLCN7_HUMAN	CLCN7	physical	26638075
CLGN_HUMAN	CLGN	physical	26638075
CLP1L_HUMAN	CLPTM1L	physical	26638075
CNIH4_HUMAN	CNIH4	physical	26638075
COPE_HUMAN	COPE	physical	26638075
EMC8_HUMAN	EMC8	physical	26638075
CYB5B_HUMAN	CYB5B	physical	26638075
NB5R3_HUMAN	CYB5R3	physical	26638075
DAD1_HUMAN	DAD1	physical	26638075
OST48_HUMAN	DDOST	physical	26638075
DDX47_HUMAN	DDX47	physical	26638075
DDX54_HUMAN	DDX54	physical	26638075
DEGS1_HUMAN	DEGS1	physical	26638075
DERL1_HUMAN	DERL1	physical	26638075
DGAT1_HUMAN	DGAT1	physical	26638075
DGKE_HUMAN	DGKE	physical	26638075
DHCR7_HUMAN	DHCR7	physical	26638075
DHRS7_HUMAN	DHRS7	physical	26638075
DRS7B_HUMAN	DHRS7B	physical	26638075
DJB11_HUMAN	DNAJB11	physical	26638075
DNJC1_HUMAN	DNAJC1	physical	26638075
DJC10_HUMAN	DNAJC10	physical	26638075
DJC11_HUMAN	DNAJC11	physical	26638075
DJC16_HUMAN	DNAJC16	physical	26638075
DNJC3_HUMAN	DNAJC3	physical	26638075
DOPP1_HUMAN	DOLPP1	physical	26638075
D19L1_HUMAN	DPY19L1	physical	26638075
D19L3_HUMAN	DPY19L3	physical	26638075
DYLT1_HUMAN	DYNLT1	physical	26638075
EBP_HUMAN	EBP	physical	26638075
EI24_HUMAN	EI24	physical	26638075
E2AK3_HUMAN	EIF2AK3	physical	26638075
ELOV1_HUMAN	ELOVL1	physical	26638075
EMD_HUMAN	EMD	physical	26638075
EPT1_HUMAN	EPT1	physical	26638075
ERGI2_HUMAN	ERGIC2	physical	26638075
ERGI3_HUMAN	ERGIC3	physical	26638075
ERP29_HUMAN	ERP29	physical	26638075
ESYT1_HUMAN	ESYT1	physical	26638075
FA2H_HUMAN	FA2H	physical	26638075
FADS2_HUMAN	FADS2	physical	26638075
FKBP8_HUMAN	FKBP8	physical	26638075
GANAB_HUMAN	GANAB	physical	26638075
GARS_HUMAN	GARS	physical	26638075
GOT1B_HUMAN	GOLT1B	physical	26638075
GPAA1_HUMAN	GPAA1	physical	26638075
GRM1A_HUMAN	GRAMD1A	physical	26638075
GSTK1_HUMAN	GSTK1	physical	26638075
HM13_HUMAN	HM13	physical	26638075
HMDH_HUMAN	HMGCR	physical	26638075
HMOX2_HUMAN	HMOX2	physical	26638075
DHB12_HUMAN	HSD17B12	physical	26638075
HSDL2_HUMAN	HSDL2	physical	26638075
ENPL_HUMAN	HSP90B1	physical	26638075
GRP78_HUMAN	HSPA5	physical	26638075
HYOU1_HUMAN	HYOU1	physical	26638075
IDH3B_HUMAN	IDH3B	physical	26638075
IKIP_HUMAN	IKBIP	physical	26638075
ILVBL_HUMAN	ILVBL	physical	26638075
ITB1_HUMAN	ITGB1	physical	26638075
JAGN1_HUMAN	JAGN1	physical	26638075
EMC1_HUMAN	EMC1	physical	26638075
KTAP2_HUMAN	KRTCAP2	physical	26638075
LBR_HUMAN	LBR	physical	26638075
LCLT1_HUMAN	LCLAT1	physical	26638075
MAN1_HUMAN	LEMD3	physical	26638075
LMAN1_HUMAN	LMAN1	physical	26638075
LMF2_HUMAN	LMF2	physical	26638075
MBOA5_HUMAN	LPCAT3	physical	26638075
LRC59_HUMAN	LRRC59	physical	26638075
MAGT1_HUMAN	MAGT1	physical	26638075
MBOA7_HUMAN	MBOAT7	physical	26638075
MFS10_HUMAN	MFSD10	physical	26638075
MGST1_HUMAN	MGST1	physical	26638075
MLEC_HUMAN	MLEC	physical	26638075
MMGT1_HUMAN	MMGT1	physical	26638075
MSPD2_HUMAN	MOSPD2	physical	26638075
NCLN_HUMAN	NCLN	physical	26638075
NDUA5_HUMAN	NDUFA5	physical	26638075
NDUA9_HUMAN	NDUFA9	physical	26638075
NDUS1_HUMAN	NDUFS1	physical	26638075
NDUS2_HUMAN	NDUFS2	physical	26638075
NDUS3_HUMAN	NDUFS3	physical	26638075
NDUS8_HUMAN	NDUFS8	physical	26638075
NDUV2_HUMAN	NDUFV2	physical	26638075
NIPS1_HUMAN	NIPSNAP1	physical	26638075
NSDHL_HUMAN	NSDHL	physical	26638075
NUCB2_HUMAN	NUCB2	physical	26638075
NU205_HUMAN	NUP205	physical	26638075
NGBR_HUMAN	NUS1	physical	26638075
ORML2_HUMAN	ORMDL2	physical	26638075
ORML3_HUMAN	ORMDL3	physical	26638075
OSBL8_HUMAN	OSBPL8	physical	26638075
P4HA1_HUMAN	P4HA1	physical	26638075
PDIA1_HUMAN	P4HB	physical	26638075
PDIA3_HUMAN	PDIA3	physical	26638075
PDIA4_HUMAN	PDIA4	physical	26638075
PDIA6_HUMAN	PDIA6	physical	26638075
PGRC1_HUMAN	PGRMC1	physical	26638075
PGRC2_HUMAN	PGRMC2	physical	26638075
GPI8_HUMAN	PIGK	physical	26638075
PIGS_HUMAN	PIGS	physical	26638075
PIGT_HUMAN	PIGT	physical	26638075
PIGU_HUMAN	PIGU	physical	26638075
PLOD1_HUMAN	PLOD1	physical	26638075
RPB1_HUMAN	POLR2A	physical	26638075
NCPR_HUMAN	POR	physical	26638075
PPIB_HUMAN	PPIB	physical	26638075
PRAF2_HUMAN	PRAF2	physical	26638075
PREB_HUMAN	PREB	physical	26638075
GLU2B_HUMAN	PRKCSH	physical	26638075
PTSS1_HUMAN	PTDSS1	physical	26638075
PTSS2_HUMAN	PTDSS2	physical	26638075
PTN1_HUMAN	PTPN1	physical	26638075
RAB31_HUMAN	RAB31	physical	26638075
RAB7A_HUMAN	RAB7A	physical	26638075
RABL3_HUMAN	RABL3	physical	26638075
RCN1_HUMAN	RCN1	physical	26638075
RCN2_HUMAN	RCN2	physical	26638075
REEP2_HUMAN	REEP2	physical	26638075
REEP4_HUMAN	REEP4	physical	26638075
REEP5_HUMAN	REEP5	physical	26638075
RER1_HUMAN	RER1	physical	26638075
RFT1_HUMAN	RFT1	physical	26638075
RHBD2_HUMAN	RHBDD2	physical	26638075
RPN1_HUMAN	RPN1	physical	26638075
RPN2_HUMAN	RPN2	physical	26638075
RTN3_HUMAN	RTN3	physical	26638075
SAMD8_HUMAN	SAMD8	physical	26638075
SAR1A_HUMAN	SAR1A	physical	26638075
SCAM2_HUMAN	SCAMP2	physical	26638075
ACOD_HUMAN	SCD	physical	26638075
SCD5_HUMAN	SCD5	physical	26638075
SC11A_HUMAN	SEC11A	physical	26638075
SC22B_HUMAN	SEC22B	physical	26638075
SEC63_HUMAN	SEC63	physical	26638075
SENP3_HUMAN	SENP3	physical	26638075
SEP15_HUMAN	SEP15	physical	26638075
SG196_HUMAN	POMK	physical	26638075
SGPL1_HUMAN	SGPL1	physical	26638075
NRAM2_HUMAN	SLC11A2	physical	26638075
S12A2_HUMAN	SLC12A2	physical	26638075
EAA1_HUMAN	SLC1A3	physical	26638075
PM34_HUMAN	SLC25A17	physical	26638075
ZNT5_HUMAN	SLC30A5	physical	26638075
ZNT6_HUMAN	SLC30A6	physical	26638075
ZNT7_HUMAN	SLC30A7	physical	26638075
ACATN_HUMAN	SLC33A1	physical	26638075
S35B4_HUMAN	SLC35B4	physical	26638075
G6PT1_HUMAN	SLC37A4	physical	26638075
S38A2_HUMAN	SLC38A2	physical	26638075
S38A9_HUMAN	SLC38A9	physical	26638075
S39AA_HUMAN	SLC39A10	physical	26638075
S39A7_HUMAN	SLC39A7	physical	26638075
SC6A8_HUMAN	SLC6A8	physical	26638075
SL9A1_HUMAN	SLC9A1	physical	26638075
NSMA3_HUMAN	SMPD4	physical	26638075
SOAT1_HUMAN	SOAT1	physical	26638075
SPCS1_HUMAN	SPCS1	physical	26638075
SPCS2_HUMAN	SPCS2	physical	26638075
SPCS3_HUMAN	SPCS3	physical	26638075
SRPRA_HUMAN	SRPR	physical	26638075
SRPRB_HUMAN	SRPRB	physical	26638075
SRSF2_HUMAN	SRSF2	physical	26638075
SSRA_HUMAN	SSR1	physical	26638075
SSRG_HUMAN	SSR3	physical	26638075
STIM1_HUMAN	STIM1	physical	26638075
STT3B_HUMAN	STT3B	physical	26638075
SUN1_HUMAN	SUN1	physical	26638075
SUN2_HUMAN	SUN2	physical	26638075
SURF4_HUMAN	SURF4	physical	26638075
TAP1_HUMAN	TAP1	physical	26638075
TAP2_HUMAN	TAP2	physical	26638075
TAPT1_HUMAN	TAPT1	physical	26638075
TFR1_HUMAN	TFRC	physical	26638075
TLCD1_HUMAN	TLCD1	physical	26638075
TLCD2_HUMAN	TLCD2	physical	26638075
TM9S2_HUMAN	TM9SF2	physical	26638075
TM9S3_HUMAN	TM9SF3	physical	26638075
TMCO1_HUMAN	TMCO1	physical	26638075
TMED2_HUMAN	TMED2	physical	26638075
TMED9_HUMAN	TMED9	physical	26638075
EMC3_HUMAN	EMC3	physical	26638075
T120B_HUMAN	TMEM120B	physical	26638075
T184C_HUMAN	TMEM184C	physical	26638075
TM199_HUMAN	TMEM199	physical	26638075
TM209_HUMAN	TMEM209	physical	26638075
TM214_HUMAN	TMEM214	physical	26638075
TM245_HUMAN	TMEM245	physical	26638075
TMM33_HUMAN	TMEM33	physical	26638075
TM38B_HUMAN	TMEM38B	physical	26638075
TM41A_HUMAN	TMEM41A	physical	26638075
TM41B_HUMAN	TMEM41B	physical	26638075
TMM43_HUMAN	TMEM43	physical	26638075
NDC1_HUMAN	NDC1	physical	26638075
EMC4_HUMAN	EMC4	physical	26638075
EMC6_HUMAN	EMC6	physical	26638075
LAP2A_HUMAN	TMPO	physical	26638075
LAP2B_HUMAN	TMPO	physical	26638075
TMTC3_HUMAN	TMTC3	physical	26638075
TMX1_HUMAN	TMX1	physical	26638075
TMX3_HUMAN	TMX3	physical	26638075
TOIP1_HUMAN	TOR1AIP1	physical	26638075
TOIP2_HUMAN	TOR1AIP2	physical	26638075
IFG15_HUMAN	TOR1AIP2	physical	26638075
P5I11_HUMAN	TP53I11	physical	26638075
TRAM1_HUMAN	TRAM1	physical	26638075
TRI13_HUMAN	TRIM13	physical	26638075
TRPM7_HUMAN	TRPM7	physical	26638075
EMC2_HUMAN	EMC2	physical	26638075
TXND5_HUMAN	TXNDC5	physical	26638075
UB2J1_HUMAN	UBE2J1	physical	26638075
UBXN4_HUMAN	UBXN4	physical	26638075
UFL1_HUMAN	UFL1	physical	26638075
UGGG1_HUMAN	UGGT1	physical	26638075
CGT_HUMAN	UGT8	physical	26638075
UN93B_HUMAN	UNC93B1	physical	26638075
VANG1_HUMAN	VANGL1	physical	26638075
VEZA_HUMAN	VEZT	physical	26638075
VKORL_HUMAN	VKORC1L1	physical	26638075
VMA21_HUMAN	VMA21	physical	26638075
VMP1_HUMAN	VMP1	physical	26638075
VRK2_HUMAN	VRK2	physical	26638075
WFS1_HUMAN	WFS1	physical	26638075
WLS_HUMAN	WLS	physical	26638075
YIF1A_HUMAN	YIF1A	physical	26638075
YIF1B_HUMAN	YIF1B	physical	26638075
YKT6_HUMAN	YKT6	physical	26638075
FACE1_HUMAN	ZMPSTE24	physical	26638075
ASIC1_HUMAN	ASIC1	physical	26638075
THEM6_HUMAN	THEM6	physical	26638075
CAC1A_HUMAN	CACNA1A	physical	26638075
CALU_HUMAN	CALU	physical	26638075
CHPT1_HUMAN	CHPT1	physical	26638075
DEP1B_HUMAN	DEPDC1B	physical	26638075
DERL2_HUMAN	DERL2	physical	26638075
GOSR2_HUMAN	GOSR2	physical	26638075
JPH1_HUMAN	JPH1	physical	26638075
LNP_HUMAN	KIAA1715	physical	26638075
LMBRL_HUMAN	LMBR1L	physical	26638075
AMRP_HUMAN	LRPAP1	physical	26638075
MBOA2_HUMAN	MBOAT2	physical	26638075
PLOD3_HUMAN	PLOD3	physical	26638075
RAB1A_HUMAN	RAB1A	physical	26638075
SGMR1_HUMAN	SIGMAR1	physical	26638075
TBL2_HUMAN	TBL2	physical	26638075
TM109_HUMAN	TMEM109	physical	26638075
TM35B_HUMAN	ZMYM6NB	physical	26638075
ERO1A_HUMAN	ERO1L	physical	26638075
ERO1B_HUMAN	ERO1LB	physical	26638075
HACD3_HUMAN	PTPLAD1	physical	26638075
HACD2_HUMAN	PTPLB	physical	26638075
CATH_HUMAN	CTSH	physical	28514442
SPA12_HUMAN	SERPINA12	physical	28514442
CBPA4_HUMAN	CPA4	physical	28514442
KPRP_HUMAN	KPRP	physical	28514442
TGM1_HUMAN	TGM1	physical	28514442
TECT1_HUMAN	TCTN1	physical	27173435

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TECT3_HUMAN

Related Literatures of Post-Translational Modification