PREB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PREB_HUMAN
• UniProt AC: Q9HCU5
• Protein Name: Prolactin regulatory element-binding protein
• Gene Name: PREB
• Organism: Homo sapiens (Human).
• Sequence Length: 417
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass membrane protein . Nucleus . Concentrates at endoplasmic reticulum exit sites.
• Protein Description: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitement of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.; Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription..
• Protein Sequence: MGRRRAPELYRAPFPLYALQVDPSTGLLIAAGGGGAAKTGIKNGVHFLQLELINGRLSASLLHSHDTETRATMNLALAGDILAAGQDAHCQLLRFQAHQQQGNKAEKAGSKEQGPRQRKGAAPAEKKCGAETQHEGLELRVENLQAVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTVGRDLKASVWQKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLRQPPPCYLTAWDGSNFLPLRTKSCGHEVVSCLDVSESGTFLGLGTVTGSVAIYIAFSLQCLYYVREAHGIVVTDVAFLPEKGRGPELLGSHETALFSVAVDSRCQLHLLPSRRSVPVWLLLLLCVGLIIVTILLLQSAFPGFL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Nitration	RRRAPELYRAPFPLY CCCCHHHHCCCCCEE	11.76	-
10	Phosphorylation	RRRAPELYRAPFPLY CCCCHHHHCCCCCEE	11.76	-
10	Nitrated tyrosine	RRRAPELYRAPFPLY CCCCHHHHCCCCCEE	11.76	-
38	Ubiquitination	AGGGGAAKTGIKNGV ECCCHHHHHCCCCCE	46.91	21906983
104	Ubiquitination	AHQQQGNKAEKAGSK HHHHHCCHHHHCCCC	65.82	21906983
107	Ubiquitination	QQGNKAEKAGSKEQG HHCCHHHHCCCCCCC	64.01	-
127	Acetylation	GAAPAEKKCGAETQH CCCCCHHHCCCCCCC	29.43	19829145
127	Ubiquitination	GAAPAEKKCGAETQH CCCCCHHHCCCCCCC	29.43	-
158	Ubiquitination	FSSDPLQKVVCFNHD CCCCCCCEEEEECCC	44.30	-
177	Phosphorylation	ATGGTDGYVRVWKVP EECCCCCEEEEEECC	6.46	-
188	Ubiquitination	WKVPSLEKVLEFKAH EECCCHHHHEEEECC	58.37	21890473
188	Ubiquitination	WKVPSLEKVLEFKAH EECCCHHHHEEEECC	58.37	21890473
209	Ubiquitination	LALGPDGKLVTVGRD EEECCCCCEEEECCC	47.35	21906983
209	2-Hydroxyisobutyrylation	LALGPDGKLVTVGRD EEECCCCCEEEECCC	47.35	-
218	Ubiquitination	VTVGRDLKASVWQKD EEECCCCCHHHHCHH	42.79	21890473
218	Acetylation	VTVGRDLKASVWQKD EEECCCCCHHHHCHH	42.79	25953088
224	Ubiquitination	LKASVWQKDQLVTQL CCHHHHCHHHHHEEE	31.56	21890473
224	Ubiquitination	LKASVWQKDQLVTQL CCHHHHCHHHHHEEE	31.56	21890473
272	Ubiquitination	FTVQIPHKRLRQPPP EEEECCCCCCCCCCC	48.01	21890473
272	Acetylation	FTVQIPHKRLRQPPP EEEECCCCCCCCCCC	48.01	25953088
272	Ubiquitination	FTVQIPHKRLRQPPP EEEECCCCCCCCCCC	48.01	21890473
295	Phosphorylation	SNFLPLRTKSCGHEV CCCCEEECCCCCCEE	34.68	-
347	Phosphorylation	EAHGIVVTDVAFLPE HHCCEEEEEEEECCC	17.54	-
355	Ubiquitination	DVAFLPEKGRGPELL EEEECCCCCCCCHHC	52.55	-
385	Phosphorylation	CQLHLLPSRRSVPVW CEEECCCCCCHHHHH	40.05	25278378

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PREB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PREB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PREB_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PREB_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.