ABD12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABD12_HUMAN
• UniProt AC: Q8N2K0
• Protein Name: Monoacylglycerol lipase ABHD12 {ECO:0000305}
• Gene Name: ABHD12 {ECO:0000312|HGNC:HGNC:15868}
• Organism: Homo sapiens (Human).
• Sequence Length: 398
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Description: Lysophosphatidylserine (LPS) lipase that plays a key role in the central nervous system. Represents a major LPS lipase in the brain (By similarity). May also have a 2-arachidonoylglycerol (2-AG) hydrolase activity and act as a regulator of endocannabinoid signaling pathways..
• Protein Sequence: MRKRTEPVALEHERCAAAGSSSSGSAAAALDADCRLKQNLRLTGPAAAEPRCAADAGMKRALGRRKGVWLRLRKILFCVLGLYIAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEEDVTIGVWHTVPAVWWKNAQGKDQMWYEDALASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPARSFRDFKVQFVPFHSDLGYRHKYIYKSPELPRILREFLGKSEPEHQH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MRKRTEPVALEH ---CCCCCCCCEECC	47.91	28857561
25	O-linked_Glycosylation	AGSSSSGSAAAALDA CCCCCCHHHHHHHCC	19.38	29351928
43	Phosphorylation	LKQNLRLTGPAAAEP HHHCEECCCCCCCCC	34.38	25159151
110	Phosphorylation	LNFVRVPYFIDLKKP HHCCCCCEEECCCCC	15.43	84577
123	N-linked_Glycosylation	KPQDQGLNHTCNYYL CCCCCCCCCCCCEEC	34.93	-
160	Phosphorylation	QGKDQMWYEDALASS CCCCCCHHHHHHHHC	9.89	25072903
166	Phosphorylation	WYEDALASSHPIILY HHHHHHHHCCCEEEE	29.99	25072903
167	Phosphorylation	YEDALASSHPIILYL HHHHHHHCCCEEEEE	27.89	25072903
173	Phosphorylation	SSHPIILYLHGNAGT HCCCEEEEECCCCCC	6.05	25072903
180	Phosphorylation	YLHGNAGTRGGDHRV EECCCCCCCCCCHHH	24.59	25072903
195	Phosphorylation	ELYKVLSSLGYHVVT HHHHHHHHCCCEEEE	22.96	110754485
232 (in isoform 2)	Ubiquitination	-	33.23	-
232	Ubiquitination	LHVFDWIKARSGDNP HHHHHHHHHCCCCCC	33.23	-
235	Phosphorylation	FDWIKARSGDNPVYI HHHHHHCCCCCCEEE	56.19	46157019
241	Phosphorylation	RSGDNPVYIWGHSLG CCCCCCEEEEEECCC	7.69	46157043
246	Phosphorylation	PVYIWGHSLGTGVAT CEEEEEECCCHHHHH	25.26	25867546
249	Phosphorylation	IWGHSLGTGVATNLV EEEECCCHHHHHHHH	33.50	25867546
253	Phosphorylation	SLGTGVATNLVRRLC CCCHHHHHHHHHHHH	27.03	25867546
273	Phosphorylation	PDALILESPFTNIRE CCCEEEECCCCCHHH	23.13	110754493
283 (in isoform 2)	Ubiquitination	-	53.21	-
283	Ubiquitination	TNIREEAKSHPFSVI CCHHHHHHHCCCCEE	53.21	-
319	Ubiquitination	FANDENVKHISCPLL ECCCCCCCCCCCCEE	46.96	-
320 (in isoform 3)	Ubiquitination	-	16.95	21890473
345	Phosphorylation	FQLGRKLYSIAAPAR CCCCCEEEEEECCCC	10.89	22309267
358 (in isoform 2)	Ubiquitination	-	39.14	21890473
358	Ubiquitination	ARSFRDFKVQFVPFH CCCCCCCEEEEEECC	39.14	2189047
358 (in isoform 1)	Ubiquitination	-	39.14	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ABD12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ABD12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABD12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DPP9_HUMAN	DPP9	physical	26186194
DPP9_HUMAN	DPP9	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H01115: Polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract (PHARC)
• OMIM Disease
• 612674: Polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract (PHARC)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.