YIF1B_HUMAN - dbPTM
YIF1B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YIF1B_HUMAN
UniProt AC Q5BJH7
Protein Name Protein YIF1B
Gene Name YIF1B
Organism Homo sapiens (Human).
Sequence Length 314
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description
Protein Sequence MHPAGLAAAAAGTPRLRKWPSKRRIPVSQPGMADPHQLFDDTSSAQSRGYGAQRAPGGLSYPAASPTPHAAFLADPVSNMAMAYGSSLAAQGKELVDKNIDRFIPITKLKYYFAVDTMYVGRKLGLLFFPYLHQDWEVQYQQDTPVAPRFDVNAPDLYIPAMAFITYVLVAGLALGTQDRFSPDLLGLQASSALAWLTLEVLAILLSLYLVTVNTDLTTIDLVAFLGYKYVGMIGGVLMGLLFGKIGYYLVLGWCCVAIFVFMIRTLRLKILADAAAEGVPVRGARNQLRMYLTMAVAAAQPMLMYWLTFHLVR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MHPAGLAA
-------CCHHHHHH		8.46-
6Phosphorylation--MHPAGLAAAAAGT
--CCHHHHHHHHHCC		2.96-
6 (in isoform 6)Phosphorylation-2.96-
13PhosphorylationLAAAAAGTPRLRKWP
HHHHHHCCCCCCCCC		10.6629255136
13 (in isoform 3)Phosphorylation-10.6629514088
13 (in isoform 5)Phosphorylation-10.6629514088
13 (in isoform 4)Phosphorylation-10.6629514088
15MethylationAAAAGTPRLRKWPSK
HHHHCCCCCCCCCCC		47.14115920217
18 (in isoform 4)Phosphorylation-68.9629514088
18 (in isoform 1)Phosphorylation-68.9624719451
18 (in isoform 3)Phosphorylation-68.9629514088
18 (in isoform 5)Phosphorylation-68.9629514088
21PhosphorylationPRLRKWPSKRRIPVS
CCCCCCCCCCCCCCC		37.3724719451
28PhosphorylationSKRRIPVSQPGMADP
CCCCCCCCCCCCCCH		25.8828555341
28O-linked_GlycosylationSKRRIPVSQPGMADP
CCCCCCCCCCCCCCH		25.8831492838
42PhosphorylationPHQLFDDTSSAQSRG
HHHHCCCCCCHHHCC		26.8226074081
43PhosphorylationHQLFDDTSSAQSRGY
HHHCCCCCCHHHCCC		30.5826074081
44PhosphorylationQLFDDTSSAQSRGYG
HHCCCCCCHHHCCCC		32.2126074081
47PhosphorylationDDTSSAQSRGYGAQR
CCCCCHHHCCCCCCC		27.6526074081
50PhosphorylationSSAQSRGYGAQRAPG
CCHHHCCCCCCCCCC		14.2626074081
52PhosphorylationAQSRGYGAQRAPGGL
HHHCCCCCCCCCCCC		6.29-
60PhosphorylationQRAPGGLSYPAASPT
CCCCCCCCCCCCCCC		32.1422199227
61PhosphorylationRAPGGLSYPAASPTP
CCCCCCCCCCCCCCC		11.2622199227
62 (in isoform 2)Ubiquitination-20.2721906983
65PhosphorylationGLSYPAASPTPHAAF
CCCCCCCCCCCCHHH		31.2625159151
67 (in isoform 2)Ubiquitination-25.8021906983
67PhosphorylationSYPAASPTPHAAFLA
CCCCCCCCCCHHHHC		25.8022199227
77 (in isoform 2)Ubiquitination-7.1321906983
78PhosphorylationAFLADPVSNMAMAYG
HHHCCHHHHHHHHHH		26.6920068231
84PhosphorylationVSNMAMAYGSSLAAQ
HHHHHHHHHHHHHHC		12.4027642862
87PhosphorylationMAMAYGSSLAAQGKE
HHHHHHHHHHHCCHH		20.05-
90 (in isoform 3)Ubiquitination-24.7721906983
90 (in isoform 4)Ubiquitination-24.7721906983
90 (in isoform 5)Ubiquitination-24.7721906983
93UbiquitinationSSLAAQGKELVDKNI
HHHHHCCHHHHHCCC		35.4821906983
93 (in isoform 1)Ubiquitination-35.4821906983
95 (in isoform 3)Ubiquitination-7.4221906983
95 (in isoform 4)Ubiquitination-7.4221906983
95 (in isoform 5)Ubiquitination-7.4221906983
98 (in isoform 1)Ubiquitination-48.6121906983
98UbiquitinationQGKELVDKNIDRFIP
CCHHHHHCCCCCCCC		48.61983
105 (in isoform 3)Ubiquitination-26.0321906983
105 (in isoform 4)Ubiquitination-26.0321906983
105 (in isoform 5)Ubiquitination-26.0321906983
108 (in isoform 1)Ubiquitination-43.6421906983
108UbiquitinationDRFIPITKLKYYFAV
CCCCCHHHHHEEEEC		43.642190698
112PhosphorylationPITKLKYYFAVDTMY
CHHHHHEEEECCCCC		5.4022817900
117PhosphorylationKYYFAVDTMYVGRKL
HEEEECCCCCHHHHH		12.1028509920
119PhosphorylationYFAVDTMYVGRKLGL
EEECCCCCHHHHHHH		11.2222817900
123UbiquitinationDTMYVGRKLGLLFFP
CCCCHHHHHHHHHHH		40.76-
270UbiquitinationMIRTLRLKILADAAA
HHHHHHHHHHHHHHH		29.28-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of YIF1B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YIF1B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YIF1B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MY18A_HUMANMYO18Aphysical
26186194
CKAP4_HUMANCKAP4physical
28514442
MY18A_HUMANMYO18Aphysical
28514442
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YIF1B_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65, AND MASSSPECTROMETRY.

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