| UniProt ID | G6PT1_HUMAN | |
|---|---|---|
| UniProt AC | O43826 | |
| Protein Name | Glucose-6-phosphate exchanger SLC37A4 {ECO:0000305|PubMed:10026167, ECO:0000305|PubMed:21949678} | |
| Gene Name | SLC37A4 {ECO:0000312|HGNC:HGNC:4061} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 429 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein . |
|
| Protein Description | Inorganic phosphate and glucose-6-phosphate antiporter of the endoplasmic reticulum. Transports cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocates inorganic phosphate into the opposite direction. Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels.. | |
| Protein Sequence | MAAQGYGYYRTVIFSAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPADVGLRNLDPMPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAGLSNYGNPRHGLLLFMMAGMTVSMYLFRVTVTSDSPKLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFLLRNIRTKMGRVSKKAE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 143 | Phosphorylation | TWWAILSTSMNLAGG HHHHHHHHCCHHCCC | 28.66 | - | |
| 144 | Phosphorylation | WWAILSTSMNLAGGL HHHHHHHCCHHCCCH | 11.42 | - | |
| 207 | Ubiquitination | DPMPSEGKKGSLKEE CCCCCCCCCCCCCCC | 50.32 | 21906983 | |
| 207 (in isoform 1) | Ubiquitination | - | 50.32 | 21906983 | |
| 207 (in isoform 2) | Ubiquitination | - | 50.32 | 21906983 | |
| 290 | Ubiquitination | LSDRAMAKAGLSNYG HCHHHHHHHCHHCCC | 29.87 | 2190698 | |
| 290 (in isoform 1) | Ubiquitination | - | 29.87 | 21906983 | |
| 290 (in isoform 2) | Ubiquitination | - | 29.87 | 21906983 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of G6PT1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of G6PT1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of G6PT1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of G6PT1_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| H00069 | Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD typ | |||||
| OMIM Disease | ||||||
| 232220 | Glycogen storage disease 1B (GSD1B) | |||||
| 232240 | Glycogen storage disease 1C (GSD1C) | |||||
| 232240 | Glycogen storage disease 1D (GSD1D) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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