DEP1B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DEP1B_HUMAN
• UniProt AC: Q8WUY9
• Protein Name: DEP domain-containing protein 1B
• Gene Name: DEPDC1B
• Organism: Homo sapiens (Human).
• Sequence Length: 529
• Protein Sequence: MEHRIVGPGPYRATRLWNETVELFRAKMPLRKHRCRFKSYEHCFTAAEAVDWLHELLRCSQNFGPEVTRKQTVQLLKKFLKNHVIEDIKGKWGEEDFEDNRHLYRFPPSSPLKPYPKKPPNQKDVIKFPEWNDLPPGTSQENIPVRPVVMNSEMWYKRHSIAIGEVPACRLVHRRQLTEANVEEIWKSMTLSYLQKILGLDSLEEVLDVKLVNSKFIIHNVYSVSKQGVVILDDKSKELPHWVLSAMKCLANWPNCSDLKQPMYLGFEKDVFKTIADYYGHLKEPLLTFHLFDAFVSVLGLLQKEKVAVEAFQICCLLLPPENRRKLQLLMRMMARICLNKEMPPLCDGFGTRTLMVQTFSRCILCSKDEVDLDELLAARLVTFLMDNYQEILKVPLALQTSIEERVAHLRRVQIKYPGADMDITLSAPSFCRQISPEEFEYQRSYGSQEPLAALLEEVITDAKLSNKEKKKKLKQFQKSYPEVYQERFPTPESAALLFPEKPKPKPQLLMWALKKPFQPFQRTRSFRM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	Phosphorylation	LHELLRCSQNFGPEV HHHHHHHHHHHCCCC	23.02	29083192
89	Ubiquitination	NHVIEDIKGKWGEED HCCHHHHCCCCCCCC	67.75	33845483
91	Ubiquitination	VIEDIKGKWGEEDFE CHHHHCCCCCCCCCC	47.20	-
109	Phosphorylation	HLYRFPPSSPLKPYP EEEECCCCCCCCCCC	44.84	28122231
110	Phosphorylation	LYRFPPSSPLKPYPK EEECCCCCCCCCCCC	39.77	28122231
123	Ubiquitination	PKKPPNQKDVIKFPE CCCCCCCCCCCCCCC	61.68	29967540
160	Phosphorylation	EMWYKRHSIAIGEVP CCCHHHHCCCCCCCC	20.11	30266825
178	Phosphorylation	LVHRRQLTEANVEEI HHHHHHCCCCCHHHH	25.39	-
188	Phosphorylation	NVEEIWKSMTLSYLQ CHHHHHHHCCHHHHH	11.29	26074081
190	Phosphorylation	EEIWKSMTLSYLQKI HHHHHHCCHHHHHHH	21.46	26074081
192	Phosphorylation	IWKSMTLSYLQKILG HHHHCCHHHHHHHHC	18.03	26074081
193	Phosphorylation	WKSMTLSYLQKILGL HHHCCHHHHHHHHCC	19.10	26074081
202	Phosphorylation	QKILGLDSLEEVLDV HHHHCCCCHHHHHCC	42.60	26074081
210	Ubiquitination	LEEVLDVKLVNSKFI HHHHHCCEEECCCEE	46.51	29967540
214	Phosphorylation	LDVKLVNSKFIIHNV HCCEEECCCEEEEEE	22.82	28555341
222	Phosphorylation	KFIIHNVYSVSKQGV CEEEEEEEEECCCCE	14.52	29496907
352	Phosphorylation	PLCDGFGTRTLMVQT CCCCCCCCCHHEEEC	20.44	22210691
417	Phosphorylation	LRRVQIKYPGADMDI HHCCEEECCCCCCEE	14.45	-
425	Phosphorylation	PGADMDITLSAPSFC CCCCCEEEECCCCHH	15.47	28122231
427	Phosphorylation	ADMDITLSAPSFCRQ CCCEEEECCCCHHCC	29.50	24719451
430	Phosphorylation	DITLSAPSFCRQISP EEEECCCCHHCCCCH	36.37	-
436	Phosphorylation	PSFCRQISPEEFEYQ CCHHCCCCHHHHCHH	20.23	30266825
440	Ubiquitination	RQISPEEFEYQRSYG CCCCHHHHCHHHHHC	11.47	33845483
442	Phosphorylation	ISPEEFEYQRSYGSQ CCHHHHCHHHHHCCC	17.97	30266825
445	Phosphorylation	EEFEYQRSYGSQEPL HHHCHHHHHCCCHHH	20.51	28450419
446	Phosphorylation	EFEYQRSYGSQEPLA HHCHHHHHCCCHHHH	24.00	28450419
448	Phosphorylation	EYQRSYGSQEPLAAL CHHHHHCCCHHHHHH	24.12	29496963
479	Ubiquitination	KKLKQFQKSYPEVYQ HHHHHHHHHCHHHHH	53.93	29967540
502	Ubiquitination	AALLFPEKPKPKPQL HHHHCCCCCCCCCCH	59.59	33845483
516	Ubiquitination	LLMWALKKPFQPFQR HHHHHHCCCCCCCCC	52.49	-
524	Phosphorylation	PFQPFQRTRSFRM-- CCCCCCCCCCCCC--	21.63	23882029
526	Phosphorylation	QPFQRTRSFRM---- CCCCCCCCCCC----	19.32	23882029

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DEP1B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DEP1B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DEP1B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EBPL_HUMAN	EBPL	physical	21988832
KI13B_HUMAN	KIF13B	physical	27173435
ZBT21_HUMAN	ZBTB21	physical	27173435
GGYF1_HUMAN	GIGYF1	physical	27173435
LRFN1_HUMAN	LRFN1	physical	27173435
SI1L1_HUMAN	SIPA1L1	physical	27173435
LIMA1_HUMAN	LIMA1	physical	27173435
MAGI1_HUMAN	MAGI1	physical	27173435
TESK2_HUMAN	TESK2	physical	27173435
DCLK1_HUMAN	DCLK1	physical	27173435
SRS12_HUMAN	SRSF12	physical	27173435
SYDE1_HUMAN	SYDE1	physical	27173435
AGAP1_HUMAN	AGAP1	physical	27173435
F110B_HUMAN	FAM110B	physical	27173435
UBP21_HUMAN	USP21	physical	27173435
F110A_HUMAN	FAM110A	physical	27173435
CBY1_HUMAN	CBY1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.