NSMA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NSMA3_HUMAN
• UniProt AC: Q9NXE4
• Protein Name: Sphingomyelin phosphodiesterase 4 {ECO:0000305}
• Gene Name: SMPD4 {ECO:0000312|HGNC:HGNC:32949}
• Organism: Homo sapiens (Human).
• Sequence Length: 866
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass membrane protein . Golgi apparatus membrane ; Single-pass membrane protein .
• Protein Description: Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. [PubMed: 16517606 May sensitize cells to DNA damage-induced apoptosis]
• Protein Sequence: MTTFGAVAEWRLPSLRRATLWIPQWFAKKAIFNSPLEAAMAFPHLQQPSFLLASLKADSINKPFAQQCQDLVKVIEDFPAKELHTIFPWLVESIFGSLDGVLVGWNLRCLQGRVNPVEYSIVMEFLDPGGPMMKLVYKLQAEDYKFDFPVSYLPGPVKASIQECILPDSPLYHNKVQFTPTGGLGLNLALNPFEYYIFFFALSLITQKPLPVSLHVRTSDCAYFILVDRYLSWFLPTEGSVPPPLSSSPGGTSPSPPPRTPAIPFASYGLHHTSLLKRHISHQTSVNADPASHEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPHAKLEVLHYRLSVSSALYSPAQPSLQALHAYQESFTPTEEHVLVVRLLLKHLHAFANSLKPEQASPSAHSHATSPLEEFKRAAVPRFVQQKLYLFLQHCFGHWPLDASFRAVLEMWLSYLQPWRYAPDKQAPGSDSQPRCVSEKWAPFVQENLLMYTKLFVGFLNRALRTDLVSPKHALMVFRVAKVFAQPNLAEMIQKGEQLFLEPELVIPHRQHRLFTAPTFTGSFLSPWPPAVTDASFKVKSHVYSLEGQDCKYTPMFGPEARTLVLRLAQLITQAKHTAKSISDQCAESPAGHSFLSWLGFSSMDTNGSYTANDLDEMGQDSVRKTDEYLEKALEYLRQIFRLSEAQLRQFTLALGTTQDENGKKQLPDCIVGEDGLILTPLGRYQIINGLRRFEIEYQGDPELQPIRSYEIASLVRTLFRLSSAINHRFAGQMAALCSRDDFLGSFCRYHLTEPGLASRHLLSPVGRRQVAGHTRGPRLSLRFLGSYRTLVSLLLAFFVASLFCVGPLPCTLLLTLGYVLYASAMTLLTERGKLHQP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTTFGAVAE ------CCCCCHHEE	27.03	26503514
2 (in isoform 6)	Phosphorylation	-	27.03	26503514
2 (in isoform 8)	Phosphorylation	-	27.03	26503514
6 (in isoform 10)	Phosphorylation	-	5.28	26552605
7	Ubiquitination	-MTTFGAVAEWRLPS -CCCCCHHEEECCHH	50.53	27667366
7 (in isoform 10)	Phosphorylation	-	50.53	26552605
7 (in isoform 3)	Ubiquitination	-	50.53	21890473
11 (in isoform 10)	Phosphorylation	-	9.13	26552605
14	Phosphorylation	VAEWRLPSLRRATLW HEEECCHHHHHHHCC	18.24	24719451
14	Ubiquitination	VAEWRLPSLRRATLW HEEECCHHHHHHHCC	18.24	21890473
14 (in isoform 3)	Ubiquitination	-	18.24	21890473
15	Ubiquitination	AEWRLPSLRRATLWI EEECCHHHHHHHCCC	30.30	21963094
16 (in isoform 10)	Phosphorylation	-	4.39	26552605
22 (in isoform 10)	Phosphorylation	-	50.31	26552605
23 (in isoform 4)	Ubiquitination	-	39.58	-
24 (in isoform 10)	Phosphorylation	-	25.89	26552605
26 (in isoform 10)	Phosphorylation	-	13.68	26552605
30	Ubiquitination	PQWFAKKAIFNSPLE CHHHHHHHHHCCHHH	42.61	21963094
34	Acetylation	AKKAIFNSPLEAAMA HHHHHHCCHHHHHHC	44.80	26051181
56	Ubiquitination	SFLLASLKADSINKP HHHHHHCCHHHCCHH	8.28	-
62	Ubiquitination	LKADSINKPFAQQCQ CCHHHCCHHHHHHHH	3.80	-
62	Ubiquitination	LKADSINKPFAQQCQ CCHHHCCHHHHHHHH	3.80	21890473
73	Ubiquitination	QQCQDLVKVIEDFPA HHHHHHHHHHHHCCH	23.66	-
89	Ubiquitination	ELHTIFPWLVESIFG HHHHHHHHHHHHHHC	52.35	21890473
91 (in isoform 8)	Phosphorylation	-	16.59	26552605
92 (in isoform 8)	Phosphorylation	-	26.13	26552605
96 (in isoform 8)	Phosphorylation	-	2.50	26552605
99	Acetylation	ESIFGSLDGVLVGWN HHHHCCCCCEEEEHH	27.00	26051181
99	Ubiquitination	ESIFGSLDGVLVGWN HHHHCCCCCEEEEHH	27.00	21906983
99 (in isoform 2)	Ubiquitination	-	27.00	21890473
99 (in isoform 4)	Ubiquitination	-	27.00	21890473
101 (in isoform 8)	Phosphorylation	-	38.26	26552605
106	Ubiquitination	DGVLVGWNLRCLQGR CCEEEEHHHHHHCCC	51.26	21906983
106 (in isoform 2)	Ubiquitination	-	51.26	21890473
106 (in isoform 4)	Ubiquitination	-	51.26	21890473
107 (in isoform 8)	Phosphorylation	-	10.75	26552605
109 (in isoform 8)	Phosphorylation	-	7.87	26552605
111 (in isoform 8)	Phosphorylation	-	6.24	26552605
121	Phosphorylation	VNPVEYSIVMEFLDP CCCCCEEEEEEEECC	21.06	24732914
130	Phosphorylation	MEFLDPGGPMMKLVY EEEECCCCHHHHEEH	18.18	25159151
130	Ubiquitination	MEFLDPGGPMMKLVY EEEECCCCHHHHEEH	18.18	21963094
133	Phosphorylation	LDPGGPMMKLVYKLQ ECCCCHHHHEEHHHH	13.51	23927012
133 (in isoform 4)	Phosphorylation	-	13.51	27642862
136	Ubiquitination	GGPMMKLVYKLQAED CCHHHHEEHHHHHCC	24.89	21890473
138	Ubiquitination	PMMKLVYKLQAEDYK HHHHEEHHHHHCCCC	37.80	27667366
138 (in isoform 1)	Ubiquitination	-	37.80	21890473
145	Ubiquitination	KLQAEDYKFDFPVSY HHHHCCCCCCCCHHH	8.15	21890473
145 (in isoform 1)	Ubiquitination	-	8.15	21890473
146	Ubiquitination	LQAEDYKFDFPVSYL HHHCCCCCCCCHHHC	18.78	21963094
169	Phosphorylation	QECILPDSPLYHNKV HHCCCCCCCCCCCCC	39.61	18691976
172	Phosphorylation	ILPDSPLYHNKVQFT CCCCCCCCCCCCEEC	23.37	-
185 (in isoform 5)	Ubiquitination	-	1.53	21890473
192 (in isoform 5)	Ubiquitination	-	3.68	21890473
194	Ubiquitination	NLALNPFEYYIFFFA CCCCCHHHHHHHHHH	9.01	21963094
202	Ubiquitination	YYIFFFALSLITQKP HHHHHHHHHHHHCCC	14.01	21890473
204	Ubiquitination	IFFFALSLITQKPLP HHHHHHHHHHCCCCC	40.07	21963094
209	Phosphorylation	LSLITQKPLPVSLHV HHHHHCCCCCEEEEE	24.96	21130716
209	Ubiquitination	LSLITQKPLPVSLHV HHHHHCCCCCEEEEE	24.96	21963094
215	Ubiquitination	KPLPVSLHVRTSDCA CCCCEEEEEECCCCE	51.17	27667366
216	Phosphorylation	PLPVSLHVRTSDCAY CCCEEEEEECCCCEE	50.21	26329039
216	Ubiquitination	PLPVSLHVRTSDCAY CCCEEEEEECCCCEE	50.21	27667366
217	Ubiquitination	LPVSLHVRTSDCAYF CCEEEEEECCCCEEE	46.42	-
221	Phosphorylation	LHVRTSDCAYFILVD EEEECCCCEEEEEEH	23.89	25850435
222	Ubiquitination	HVRTSDCAYFILVDR EEECCCCEEEEEEHH	29.48	21890473
223	Ubiquitination	VRTSDCAYFILVDRY EECCCCEEEEEEHHH	22.82	21890473
224 (in isoform 5)	Ubiquitination	-	2.80	21890473
228	Phosphorylation	CAYFILVDRYLSWFL CEEEEEEHHHHHHCC	21.80	27080861
229	Phosphorylation	AYFILVDRYLSWFLP EEEEEEHHHHHHCCC	21.92	20068231
234	Phosphorylation	VDRYLSWFLPTEGSV EHHHHHHCCCCCCCC	15.43	20068231
235	Phosphorylation	DRYLSWFLPTEGSVP HHHHHHCCCCCCCCC	27.61	20068231
238 (in isoform 2)	Ubiquitination	-	47.42	-
238 (in isoform 4)	Ubiquitination	-	47.42	-
240 (in isoform 6)	Phosphorylation	-	25.06	26552605
241	Ubiquitination	FLPTEGSVPPPLSSS CCCCCCCCCCCCCCC	4.58	21890473
241	Ubiquitination	FLPTEGSVPPPLSSS CCCCCCCCCCCCCCC	4.58	21890473
241 (in isoform 6)	Phosphorylation	-	4.58	26552605
242	Phosphorylation	LPTEGSVPPPLSSSP CCCCCCCCCCCCCCC	11.92	26055452
245	Phosphorylation	EGSVPPPLSSSPGGT CCCCCCCCCCCCCCC	29.26	21712546
245 (in isoform 6)	Phosphorylation	-	29.26	26552605
246	Phosphorylation	GSVPPPLSSSPGGTS CCCCCCCCCCCCCCC	13.55	21712546
249	Ubiquitination	PPPLSSSPGGTSPSP CCCCCCCCCCCCCCC	23.24	21890473
249	Ubiquitination	PPPLSSSPGGTSPSP CCCCCCCCCCCCCCC	23.24	21890473
250 (in isoform 6)	Phosphorylation	-	33.81	26552605
253	Phosphorylation	SSSPGGTSPSPPPRT CCCCCCCCCCCCCCC	27.35	23312004
254	Ubiquitination	SSPGGTSPSPPPRTP CCCCCCCCCCCCCCC	32.44	27667366
256 (in isoform 6)	Phosphorylation	-	2.87	26552605
258 (in isoform 6)	Phosphorylation	-	30.21	26552605
260	Phosphorylation	SPSPPPRTPAIPFAS CCCCCCCCCCCCCHH	34.60	24719451
260 (in isoform 6)	Phosphorylation	-	34.60	26552605
267	Phosphorylation	TPAIPFASYGLHHTS CCCCCCHHCCCHHHH	5.32	20068231
268	Phosphorylation	PAIPFASYGLHHTSL CCCCCHHCCCHHHHH	17.12	24719451
273	Phosphorylation	ASYGLHHTSLLKRHI HHCCCHHHHHHHHHH	16.23	24719451
274 (in isoform 2)	Phosphorylation	-	12.28	26552605
275 (in isoform 2)	Phosphorylation	-	17.31	26552605
277	Ubiquitination	LHHTSLLKRHISHQT CHHHHHHHHHHCCCC	29.88	21963094
279 (in isoform 2)	Phosphorylation	-	8.80	26552605
281	Phosphorylation	SLLKRHISHQTSVNA HHHHHHHCCCCCCCC	22.78	-
284	Phosphorylation	KRHISHQTSVNADPA HHHHCCCCCCCCCCC	18.36	24719451
284 (in isoform 2)	Phosphorylation	-	18.36	26552605
285	Phosphorylation	RHISHQTSVNADPAS HHHCCCCCCCCCCCC	17.98	27251275
289	Ubiquitination	HQTSVNADPASHEIW CCCCCCCCCCCHHHH	5.97	21890473
290 (in isoform 2)	Phosphorylation	-	42.18	26552605
292 (in isoform 2)	Phosphorylation	-	1.83	26552605
294 (in isoform 2)	Phosphorylation	-	14.75	26552605
296	Ubiquitination	DPASHEIWRSETLLQ CCCCHHHHHHHHHHH	4.70	21890473
297	Phosphorylation	PASHEIWRSETLLQV CCCHHHHHHHHHHHH	15.79	18691976
309	Ubiquitination	LQVFVEMWLHHYSLE HHHHHHHHHHHHHHH	22.49	21963094
317	Ubiquitination	LHHYSLEMYQKMQSP HHHHHHHHHHHHCCC	40.41	-
322	Ubiquitination	LEMYQKMQSPHAKLE HHHHHHHCCCCHHHH	35.48	21963094
322 (in isoform 3)	Ubiquitination	-	35.48	21890473
323	Phosphorylation	EMYQKMQSPHAKLEV HHHHHHCCCCHHHHH	51.45	24719451
328	Ubiquitination	MQSPHAKLEVLHYRL HCCCCHHHHHHHHHH	2.96	21890473
329	Ubiquitination	QSPHAKLEVLHYRLS CCCCHHHHHHHHHHC	1.98	-
336	Phosphorylation	EVLHYRLSVSSALYS HHHHHHHCHHHHHCC	23.87	18691976
337	Ubiquitination	VLHYRLSVSSALYSP HHHHHHCHHHHHCCC	2.73	21963094
343	Phosphorylation	SVSSALYSPAQPSLQ CHHHHHCCCCCHHHH	34.05	24173317
350	Phosphorylation	SPAQPSLQALHAYQE CCCCHHHHHHHHHHH	21.05	28464451
351	Ubiquitination	PAQPSLQALHAYQES CCCHHHHHHHHHHHC	38.25	21963094
352	Phosphorylation	AQPSLQALHAYQESF CCHHHHHHHHHHHCC	35.80	18691976
352 (in isoform 4)	Phosphorylation	-	35.80	21406692
353	Ubiquitination	QPSLQALHAYQESFT CHHHHHHHHHHHCCC	16.16	-
355	Phosphorylation	SLQALHAYQESFTPT HHHHHHHHHHCCCCC	17.97	26425664
355	Ubiquitination	SLQALHAYQESFTPT HHHHHHHHHHCCCCC	17.97	21963094
358	Phosphorylation	ALHAYQESFTPTEEH HHHHHHHCCCCCHHH	26.00	21406692
359	Phosphorylation	LHAYQESFTPTEEHV HHHHHHCCCCCHHHH	28.42	21406692
366	Ubiquitination	FTPTEEHVLVVRLLL CCCCHHHHHHHHHHH	32.85	21963094
369	Ubiquitination	TEEHVLVVRLLLKHL CHHHHHHHHHHHHHH	3.22	21890473
369 (in isoform 3)	Ubiquitination	-	3.22	21890473
382 (in isoform 4)	Phosphorylation	-	24.78	23663014
384	Ubiquitination	HAFANSLKPEQASPS HHHHHCCCHHHCCCC	2.56	-
385 (in isoform 2)	Ubiquitination	-	8.27	21890473
385 (in isoform 4)	Phosphorylation	-	8.27	23663014
389	Phosphorylation	SLKPEQASPSAHSHA CCCHHHCCCCCCCCC	18.06	20068231
391	Phosphorylation	KPEQASPSAHSHATS CHHHCCCCCCCCCCC	35.77	18691976
392 (in isoform 4)	Phosphorylation	-	20.46	22210691
393 (in isoform 4)	Phosphorylation	-	18.22	29083192
394	Ubiquitination	QASPSAHSHATSPLE HCCCCCCCCCCCCHH	6.61	21890473
394	Ubiquitination	QASPSAHSHATSPLE HCCCCCCCCCCCCHH	6.61	27667366
398	Ubiquitination	SAHSHATSPLEEFKR CCCCCCCCCHHHHHH	3.49	21890473
398	Acetylation	SAHSHATSPLEEFKR CCCCCCCCCHHHHHH	3.49	19608861
398	Ubiquitination	SAHSHATSPLEEFKR CCCCCCCCCHHHHHH	3.49	21890473
400 (in isoform 2)	Ubiquitination	-	3.69	-
401	Ubiquitination	SHATSPLEEFKRAAV CCCCCCHHHHHHHHH	3.47	21890473
401	Ubiquitination	SHATSPLEEFKRAAV CCCCCCHHHHHHHHH	3.47	21890473
402	Ubiquitination	HATSPLEEFKRAAVP CCCCCHHHHHHHHHH	2.02	21890473
409	Acetylation	EFKRAAVPRFVQQKL HHHHHHHHHHHHHHH	25.15	-
409	Ubiquitination	EFKRAAVPRFVQQKL HHHHHHHHHHHHHHH	25.15	21890473
409	Ubiquitination	EFKRAAVPRFVQQKL HHHHHHHHHHHHHHH	25.15	21890473
410	Phosphorylation	FKRAAVPRFVQQKLY HHHHHHHHHHHHHHH	20.72	23898821
414	Acetylation	AVPRFVQQKLYLFLQ HHHHHHHHHHHHHHH	47.50	26051181
414	Ubiquitination	AVPRFVQQKLYLFLQ HHHHHHHHHHHHHHH	47.50	21906983
419	Phosphorylation	VQQKLYLFLQHCFGH HHHHHHHHHHHHHCC	32.79	29396449
421	Phosphorylation	QKLYLFLQHCFGHWP HHHHHHHHHHHCCCC	43.72	28102081
421	Ubiquitination	QKLYLFLQHCFGHWP HHHHHHHHHHHCCCC	43.72	33845483
424	Ubiquitination	YLFLQHCFGHWPLDA HHHHHHHHCCCCCCH	26.32	21963094
432 (in isoform 2)	Ubiquitination	-	28.91	21890473
433	Ubiquitination	HWPLDASFRAVLEMW CCCCCHHHHHHHHHH	7.37	21890473
433	Ubiquitination	HWPLDASFRAVLEMW CCCCCHHHHHHHHHH	7.37	27667366
437	Ubiquitination	DASFRAVLEMWLSYL CHHHHHHHHHHHHHH	22.76	21963094
439	Ubiquitination	SFRAVLEMWLSYLQP HHHHHHHHHHHHHCC	3.58	21963094
441	Ubiquitination	RAVLEMWLSYLQPWR HHHHHHHHHHHCCCC	10.74	21890473
442	Ubiquitination	AVLEMWLSYLQPWRY HHHHHHHHHHCCCCC	13.80	-
451	Dimethylation	LQPWRYAPDKQAPGS HCCCCCCCCCCCCCC	36.83	-
453	Ubiquitination	PWRYAPDKQAPGSDS CCCCCCCCCCCCCCC	5.67	21963094
453 (in isoform 1)	Ubiquitination	-	5.67	21890473
458	Phosphorylation	PDKQAPGSDSQPRCV CCCCCCCCCCCCCCC	11.65	24719451
459	Phosphorylation	DKQAPGSDSQPRCVS CCCCCCCCCCCCCCC	35.21	24719451
460 (in isoform 4)	Ubiquitination	-	25.60	21890473
461	Acetylation	QAPGSDSQPRCVSEK CCCCCCCCCCCCCCC	33.72	26051181
461	Malonylation	QAPGSDSQPRCVSEK CCCCCCCCCCCCCCC	33.72	26320211
461	Ubiquitination	QAPGSDSQPRCVSEK CCCCCCCCCCCCCCC	33.72	-
466	Ubiquitination	DSQPRCVSEKWAPFV CCCCCCCCCCCHHHH	2.63	21963094
468	Ubiquitination	QPRCVSEKWAPFVQE CCCCCCCCCHHHHHH	18.97	21963094
471	Acetylation	CVSEKWAPFVQENLL CCCCCCHHHHHHHHH	34.72	26051181
471	Malonylation	CVSEKWAPFVQENLL CCCCCCHHHHHHHHH	34.72	26320211
471	Ubiquitination	CVSEKWAPFVQENLL CCCCCCHHHHHHHHH	34.72	21890473
478	Ubiquitination	PFVQENLLMYTKLFV HHHHHHHHHHHHHHH	5.63	32015554
494	Ubiquitination	FLNRALRTDLVSPKH HHHHHHHCCCCCHHH	6.56	33845483
500	Acetylation	RTDLVSPKHALMVFR HCCCCCHHHHHHHHH	24.02	19608861
500	Ubiquitination	RTDLVSPKHALMVFR HCCCCCHHHHHHHHH	24.02	21890473
500 (in isoform 1)	Ubiquitination	-	24.02	21890473
502	Ubiquitination	DLVSPKHALMVFRVA CCCCHHHHHHHHHHH	24.14	21963094
505	Phosphorylation	SPKHALMVFRVAKVF CHHHHHHHHHHHHHH	36.00	25693802
507 (in isoform 4)	Ubiquitination	-	25.61	21890473
508	Phosphorylation	HALMVFRVAKVFAQP HHHHHHHHHHHHCCC	31.22	30622161
510	Phosphorylation	LMVFRVAKVFAQPNL HHHHHHHHHHCCCCH	34.10	28348404
512	Phosphorylation	VFRVAKVFAQPNLAE HHHHHHHHCCCCHHH	21.69	25693802
515	Phosphorylation	VAKVFAQPNLAEMIQ HHHHHCCCCHHHHHH	23.94	28348404
517	Ubiquitination	KVFAQPNLAEMIQKG HHHCCCCHHHHHHHC	14.24	21963094
522	Ubiquitination	PNLAEMIQKGEQLFL CCHHHHHHHCCCCCC	28.14	27667366
522 (in isoform 3)	Ubiquitination	-	28.14	21890473
525	Phosphorylation	AEMIQKGEQLFLEPE HHHHHHCCCCCCCCC	28.54	24719451
529	Ubiquitination	QKGEQLFLEPELVIP HHCCCCCCCCCEEEC	35.12	21890473
529 (in isoform 3)	Ubiquitination	-	35.12	21890473
531	Ubiquitination	GEQLFLEPELVIPHR CCCCCCCCCEEECCC	19.47	21963094
539	Ubiquitination	ELVIPHRQHRLFTAP CEEECCCCCCCEECC	41.55	21963094
541	Acetylation	VIPHRQHRLFTAPTF EECCCCCCCEECCCC	61.52	-
541	Ubiquitination	VIPHRQHRLFTAPTF EECCCCCCCEECCCC	61.52	-
546	Ubiquitination	QHRLFTAPTFTGSFL CCCCEECCCCCCCCC	18.18	21963094
549	Ubiquitination	LFTAPTFTGSFLSPW CEECCCCCCCCCCCC	51.68	21890473
551	Phosphorylation	TAPTFTGSFLSPWPP ECCCCCCCCCCCCCC	27.25	24719451
551	Ubiquitination	TAPTFTGSFLSPWPP ECCCCCCCCCCCCCC	27.25	27667366
552	Phosphorylation	APTFTGSFLSPWPPA CCCCCCCCCCCCCCC	28.41	25106551
558	Ubiquitination	SFLSPWPPAVTDASF CCCCCCCCCCCCCCC	8.83	21890473
558	Ubiquitination	SFLSPWPPAVTDASF CCCCCCCCCCCCCCC	8.83	21890473
561	Ubiquitination	SPWPPAVTDASFKVK CCCCCCCCCCCCEEE	1.46	27667366
561 (in isoform 3)	Ubiquitination	-	1.46	21890473
565	Ubiquitination	PAVTDASFKVKSHVY CCCCCCCCEEEEEEE	31.50	-
568	Ubiquitination	TDASFKVKSHVYSLE CCCCCEEEEEEEEEC	11.87	21963094
575 (in isoform 4)	Ubiquitination	-	5.64	-
578	Ubiquitination	VYSLEGQDCKYTPMF EEEECCCCCEECCCC	11.09	21890473
579 (in isoform 4)	Phosphorylation	-	33.49	27642862
580	Ubiquitination	SLEGQDCKYTPMFGP EECCCCCEECCCCCH	37.29	-
585 (in isoform 2)	Ubiquitination	-	3.94	21890473
587 (in isoform 4)	Ubiquitination	-	11.58	-
590	Ubiquitination	PMFGPEARTLVLRLA CCCCHHHHHHHHHHH	4.59	27667366
592 (in isoform 2)	Ubiquitination	-	20.58	21890473
604	Ubiquitination	AQLITQAKHTAKSIS HHHHHHHHHHHHHHH	6.36	-
611 (in isoform 4)	Ubiquitination	-	18.88	-
614	Ubiquitination	AKSISDQCAESPAGH HHHHHHHHHCCCCCC	59.16	21906983
615	Phosphorylation	KSISDQCAESPAGHS HHHHHHHHCCCCCCC	24.41	29083192
617	Ubiquitination	ISDQCAESPAGHSFL HHHHHHCCCCCCCHH	58.19	21963094
618	Phosphorylation	SDQCAESPAGHSFLS HHHHHCCCCCCCHHH	23.99	29083192
621	Acetylation	CAESPAGHSFLSWLG HHCCCCCCCHHHHHC	56.53	25038526
621	Ubiquitination	CAESPAGHSFLSWLG HHCCCCCCCHHHHHC	56.53	21906983
624	Ubiquitination	SPAGHSFLSWLGFSS CCCCCCHHHHHCCCC	47.59	27667366
624 (in isoform 2)	Ubiquitination	-	47.59	21890473
625	Phosphorylation	PAGHSFLSWLGFSSM CCCCCHHHHHCCCCC	14.18	29083192
631	Ubiquitination	LSWLGFSSMDTNGSY HHHHCCCCCCCCCCE	38.64	21890473
633	Phosphorylation	WLGFSSMDTNGSYTA HHCCCCCCCCCCEEC	26.99	27251275
640 (in isoform 2)	Phosphorylation	-	4.96	19081932
641	Phosphorylation	TNGSYTANDLDEMGQ CCCCEECCHHHHHCH	11.63	25867546
646	Phosphorylation	TANDLDEMGQDSVRK ECCHHHHHCHHHHHH	23.33	25867546
646	Ubiquitination	TANDLDEMGQDSVRK ECCHHHHHCHHHHHH	23.33	21963094
647	Phosphorylation	ANDLDEMGQDSVRKT CCHHHHHCHHHHHHH	32.02	25867546
653	Ubiquitination	MGQDSVRKTDEYLEK HCHHHHHHHHHHHHH	49.26	21906983
653 (in isoform 1)	Ubiquitination	-	49.26	21890473
654	Ubiquitination	GQDSVRKTDEYLEKA CHHHHHHHHHHHHHH	59.47	-
660	Ubiquitination	KTDEYLEKALEYLRQ HHHHHHHHHHHHHHH	6.10	21890473
660 (in isoform 1)	Ubiquitination	-	6.10	21890473
660 (in isoform 4)	Ubiquitination	-	6.10	21890473
663	Ubiquitination	EYLEKALEYLRQIFR HHHHHHHHHHHHHHH	37.70	27667366
667 (in isoform 4)	Ubiquitination	-	5.01	21890473
669	Phosphorylation	LEYLRQIFRLSEAQL HHHHHHHHHHCHHHH	14.96	21712546
672	Phosphorylation	LRQIFRLSEAQLRQF HHHHHHHCHHHHHHH	27.70	27251275
690	Phosphorylation	LGTTQDENGKKQLPD HCCCCCCCCCCCCCC	20.27	32645325
692	Ubiquitination	TTQDENGKKQLPDCI CCCCCCCCCCCCCCE	65.85	27667366
692 (in isoform 1)	Ubiquitination	-	65.85	21890473
693	Ubiquitination	TQDENGKKQLPDCIV CCCCCCCCCCCCCEE	9.99	-
699 (in isoform 4)	Ubiquitination	-	11.08	21890473
700 (in isoform 4)	Ubiquitination	-	33.07	-
702	Ubiquitination	LPDCIVGEDGLILTP CCCCEECCCCEEEEC	5.72	27667366
708	Phosphorylation	GEDGLILTPLGRYQI CCCCEEEECCCHHEE	1.32	24719451
709	Ubiquitination	EDGLILTPLGRYQII CCCEEEECCCHHEEE	7.95	21890473
731	Ubiquitination	IEYQGDPELQPIRSY EEECCCCCCCCCCHH	39.29	27667366
733 (in isoform 4)	Phosphorylation	-	7.85	27642862
738	Ubiquitination	ELQPIRSYEIASLVR CCCCCCHHHHHHHHH	21.64	21890473
741	Ubiquitination	PIRSYEIASLVRTLF CCCHHHHHHHHHHHH	4.26	27667366
748	Phosphorylation	ASLVRTLFRLSSAIN HHHHHHHHHHHHHHH	25.85	28555341
753	Phosphorylation	TLFRLSSAINHRFAG HHHHHHHHHHHHHHH	24.73	28176443
763	Phosphorylation	HRFAGQMAALCSRDD HHHHHHHHHHHCCCH	11.58	32645325
770	Phosphorylation	AALCSRDDFLGSFCR HHHHCCCHHHHHHHH	20.83	23532336
770	Ubiquitination	AALCSRDDFLGSFCR HHHHCCCHHHHHHHH	20.83	27667366
792	Phosphorylation	LASRHLLSPVGRRQV HHHCCCCCCCCCCCC	2.51	18691976
799 (in isoform 4)	Phosphorylation	-	16.51	21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NSMA3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NSMA3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NSMA3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NSMA3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00144: Phosphatidylserine

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-461, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, AND MASSSPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130; THR-669 ANDSER-753, AND MASS SPECTROMETRY.
PubMed: 18691976

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-350 AND SER-753, ANDMASS SPECTROMETRY.
PubMed: 19007248

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-753, AND MASSSPECTROMETRY.
PubMed: 17924679