dbPTM

ABCBA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ABCBA_HUMAN
UniProt AC	Q9NRK6
Protein Name	ATP-binding cassette sub-family B member 10, mitochondrial
Gene Name	ABCB10
Organism	Homo sapiens (Human).
Sequence Length	738
Subcellular Localization	Mitochondrion inner membrane Multi-pass membrane protein.
Protein Description	May mediate critical mitochondrial transport functions related to heme biosynthesis..
Protein Sequence	MRGPPAWPLRLLEPPSPAEPGRLLPVACVWAAASRVPGSLSPFTGLRPARLWGAGPALLWGVGAARRWRSGCRGGGPGASRGVLGLARLLGLWARGPGSCRCGAFAGPGAPRLPRARFPGGPAAAAWAGDEAWRRGPAAPPGDKGRLRPAAAGLPEARKLLGLAYPERRRLAAAVGFLTMSSVISMSAPFFLGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQSFISA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	LRLLEPPSPAEPGRL CCCCCCCCCCCCCCC	47.67	26074081
80	Phosphorylation	RGGGPGASRGVLGLA CCCCCCHHHHHHHHH	35.17	50558515
86	Ubiquitination	ASRGVLGLARLLGLW HHHHHHHHHHHHCHH	1.88	24816145
159	Ubiquitination	AGLPEARKLLGLAYP CCCHHHHHHHCCCCH	55.93	21890473
207	Phosphorylation	YTNPTVDYSDNLTRL ECCCCCCCCCHHHHH	17.37	46156643
208	Phosphorylation	TNPTVDYSDNLTRLC CCCCCCCCCHHHHHH	18.63	46156631
212	Phosphorylation	VDYSDNLTRLCLGLS CCCCCHHHHHHHHHH	28.05	46156637
219	Phosphorylation	TRLCLGLSAVFLCGA HHHHHHHHHHHHHHH	22.16	22210691
254	Phosphorylation	LRTSLFSSILRQEVA HHHHHHHHHHHHHHH	20.50	24719451
265	Ubiquitination	QEVAFFDKTRTGELI HHHHHCCCCCHHHHH	34.45	24816145
265	Acetylation	QEVAFFDKTRTGELI HHHHHCCCCCHHHHH	34.45	19608861
341	Malonylation	RYLRKLTKVTQDSLA HHHHHHCCCCHHHHH	54.44	26320211
351	Phosphorylation	QDSLAQATQLAEERI HHHHHHHHHHHHHHH	16.43	26657352
351	O-linked_Glycosylation	QDSLAQATQLAEERI HHHHHHHHHHHHHHH	16.43	29351928
363	Phosphorylation	ERIGNVRTVRAFGKE HHHCCHHHHHHCCCC	15.29	63650289
369	Ubiquitination	RTVRAFGKEMTEIEK HHHHHCCCCHHHHHH	37.55	-
377	Phosphorylation	EMTEIEKYASKVDHV CHHHHHHHHHHHHHH	11.87	22468782
380	Malonylation	EIEKYASKVDHVMQL HHHHHHHHHHHHHHH	43.44	26320211
380	Ubiquitination	EIEKYASKVDHVMQL HHHHHHHHHHHHHHH	43.44	-
385	Sulfoxidation	ASKVDHVMQLARKEA HHHHHHHHHHHHHHH	2.13	21406390
486	Ubiquitination	EGVILNEKSFQGALE CCCCCCCCCCCCCEE	56.34	-
661	Phosphorylation	ILLLDEATSALDAEN EEEECCCCCCCHHCC	16.69	24275569
700	Sulfoxidation	STIKNANMVAVLDQG HHCCCCCEEEEEECC	1.58	21406390
732	Ubiquitination	IYRKLMNKQSFISA- HHHHHHCCHHHHCC-	33.10	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ABCBA_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ABCBA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ABCBA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NDUA2_HUMAN	NDUFA2	physical	22939629
NDUBB_HUMAN	NDUFB11	physical	22939629
ECSIT_HUMAN	ECSIT	physical	22939629
LTOR2_HUMAN	LAMTOR2	physical	22939629
BAK_HUMAN	BAK1	physical	22939629

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ABCBA_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-265, AND MASS SPECTROMETRY.	19608861 [Abstract]