| UniProt ID | MFS10_HUMAN | |
|---|---|---|
| UniProt AC | Q14728 | |
| Protein Name | Major facilitator superfamily domain-containing protein 10 | |
| Gene Name | MFSD10 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 455 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein . |
|
| Protein Description | Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump.. | |
| Protein Sequence | MGWGGGGGCTPRPPIHQQPPERRVVTVVFLGLLLDLLAFTLLLPLLPGLLESHGRAHDPLYGSWQGGVDWFATAIGMPVEKRYNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAASDLLFIFCFLPETLPLEKRAPSIALGFRDAADLLSPLALLRFSAVARGQDPPSGDRLSSLRRLGLVYFLYLFLFSGLEYTLSFLTHQRFQFSSLQQGKMFFLIGLTMATIQGAYARRIHPGGEVAAVKRALLLLVPAFLLIGWGRSLPVLGLGLLLYSFAAAVVVPCLSSVVAGYGSPGQKGTVMGTLRSLGALARAAGPLVAASVYWLAGAQACFTTWSGLFLLPFFLLQKLSYPAQTLKAE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 81 | Ubiquitination | AIGMPVEKRYNSVLF HHCCCHHHHCCHHHH | 61.49 | - | |
| 154 | Ubiquitination | RLIGGISKGNVSLST HHHCCCCCCCCCCCH | 53.21 | - | |
| 247 | Phosphorylation | RDAADLLSPLALLRF CCHHHHHHHHHHHHH | 25.76 | - | |
| 270 | Phosphorylation | PPSGDRLSSLRRLGL CCCCCHHHHHHHHHH | 28.37 | 22167270 | |
| 271 | Phosphorylation | PSGDRLSSLRRLGLV CCCCHHHHHHHHHHH | 30.41 | 22167270 | |
| 340 | Ubiquitination | GGEVAAVKRALLLLV CCHHHHHHHHHHHHH | 27.51 | 2190698 | |
| 340 | 2-Hydroxyisobutyrylation | GGEVAAVKRALLLLV CCHHHHHHHHHHHHH | 27.51 | - | |
| 395 | Phosphorylation | GSPGQKGTVMGTLRS CCCCCCCCHHHHHHH | 17.85 | 25072903 | |
| 399 | Phosphorylation | QKGTVMGTLRSLGAL CCCCHHHHHHHHHHH | 10.82 | 25072903 | |
| 402 | Phosphorylation | TVMGTLRSLGALARA CHHHHHHHHHHHHHH | 33.98 | 25072903 | |
| 453 | Ubiquitination | SYPAQTLKAE----- CCCCHHHCCC----- | 54.58 | 21906983 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MFS10_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MFS10_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MFS10_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MFS10_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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