GPAT3_HUMAN - dbPTM
GPAT3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GPAT3_HUMAN
UniProt AC Q53EU6
Protein Name Glycerol-3-phosphate acyltransferase 3 {ECO:0000312|HGNC:HGNC:28157}
Gene Name GPAT3 {ECO:0000312|HGNC:HGNC:28157}
Organism Homo sapiens (Human).
Sequence Length 434
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description May transfer the acyl-group from acyl-coA to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Also transfers the acyl-group from acyl-coA to the sn-2 position of 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, or LPA), forming 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid, or PA)..
Protein Sequence MEGAELAGKILSTWLTLVLGFILLPSVFGVSLGISEIYMKILVKTLEWATIRIEKGTPKESILKNSASVGIIQRDESPMEKGLSGLRGRDFELSDVFYFSKKGLEAIVEDEVTQRFSSEELVSWNLLTRTNVNFQYISLRLTMVWVLGVIVRYCVLLPLRVTLAFIGISLLVIGTTLVGQLPDSSLKNWLSELVHLTCCRICVRALSGTIHYHNKQYRPQKGGICVANHTSPIDVLILTTDGCYAMVGQVHGGLMGIIQRAMVKACPHVWFERSEMKDRHLVTKRLKEHIADKKKLPILIFPEGTCINNTSVMMFKKGSFEIGGTIHPVAIKYNPQFGDAFWNSSKYNMVSYLLRMMTSWAIVCDVWYMPPMTREEGEDAVQFANRVKSAIAIQGGLTELPWDGGLKRAKVKDIFKEEQQKNYSKMIVGNGSLS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationELAGKILSTWLTLVL
HHHHHHHHHHHHHHH		22.4720860994
13PhosphorylationLAGKILSTWLTLVLG
HHHHHHHHHHHHHHH		22.5020860994
16PhosphorylationKILSTWLTLVLGFIL
HHHHHHHHHHHHHHH		13.3320860994
26PhosphorylationLGFILLPSVFGVSLG
HHHHHHHHHHCCCCC		30.0120860994
59UbiquitinationRIEKGTPKESILKNS
EECCCCCHHHHHHCC		65.02-
61PhosphorylationEKGTPKESILKNSAS
CCCCCHHHHHHCCCE		39.0724719451
64UbiquitinationTPKESILKNSASVGI
CCHHHHHHCCCEEEE		47.3821890473
66PhosphorylationKESILKNSASVGIIQ
HHHHHHCCCEEEEEE		21.9730266825
68PhosphorylationSILKNSASVGIIQRD
HHHHCCCEEEEEECC		22.2425159151
77PhosphorylationGIIQRDESPMEKGLS
EEEECCCCHHHHCCC		33.5629255136
81UbiquitinationRDESPMEKGLSGLRG
CCCCHHHHCCCCCCC		59.9221890473
84PhosphorylationSPMEKGLSGLRGRDF
CHHHHCCCCCCCCCC		44.4424719451
101UbiquitinationSDVFYFSKKGLEAIV
HHEEEEECCCHHHHH		40.75-
102UbiquitinationDVFYFSKKGLEAIVE
HEEEEECCCHHHHHC		68.4821890473
123PhosphorylationFSSEELVSWNLLTRT
CCCHHHHHCCCCCCC		23.9126074081
264UbiquitinationIIQRAMVKACPHVWF
HHHHHHHHHCCCEEE		31.05-
283PhosphorylationMKDRHLVTKRLKEHI
CCHHHHHHHHHHHHH		19.4624719451
284AcetylationKDRHLVTKRLKEHIA
CHHHHHHHHHHHHHC		48.5319828349
316AcetylationNTSVMMFKKGSFEIG
CCEEEEEECCEEECC		38.0326051181
347PhosphorylationAFWNSSKYNMVSYLL
CCCCCCHHHHHHHHH		15.5011027811
352PhosphorylationSKYNMVSYLLRMMTS
CHHHHHHHHHHHHHH		9.8011027823
368PhosphorylationAIVCDVWYMPPMTRE
HHHEEEEECCCCCHH		10.2922210691
373PhosphorylationVWYMPPMTREEGEDA
EEECCCCCHHCCHHH		40.4822210691
388UbiquitinationVQFANRVKSAIAIQG
HHHHHHHHHHHHHCC		30.8221890473
407AcetylationLPWDGGLKRAKVKDI
CCCCCCCCHHHHHHH		54.2924431325
407UbiquitinationLPWDGGLKRAKVKDI
CCCCCCCCHHHHHHH		54.2921890473
434PhosphorylationIVGNGSLS-------
ECCCCCCC-------		39.6125159151
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GPAT3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GPAT3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GPAT3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of GPAT3_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GPAT3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68 AND SER-77, AND MASSSPECTROMETRY.
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68, AND MASSSPECTROMETRY.

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