| UniProt ID | SCD5_HUMAN | |
|---|---|---|
| UniProt AC | Q86SK9 | |
| Protein Name | Stearoyl-CoA desaturase 5 {ECO:0000305} | |
| Gene Name | SCD5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 330 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein . |
|
| Protein Description | Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. [PubMed: 15907797] | |
| Protein Sequence | MPGPATDAGKIPFCDAKEEIRAGLESSEGGGGPERPGARGQRQNIVWRNVVLMSLLHLGAVYSLVLIPKAKPLTLLWAYFCFLLAALGVTAGAHRLWSHRSYRAKLPLRIFLAVANSMAFQNDIFEWSRDHRAHHKYSETDADPHNARRGFFFSHIGWLFVRKHRDVIEKGRKLDVTDLLADPVVRIQRKYYKISVVLMCFVVPTLVPWYIWGESLWNSYFLASILRYTISLNISWLVNSAAHMYGNRPYDKHISPRQNPLVALGAIGEGFHNYHHTFPFDYSASEFGLNFNPTTWFIDFMCWLGLATDRKRATKPMIEARKARTGDSSA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Ubiquitination | GPATDAGKIPFCDAK CCCCCCCCCCCCCHH | 49.26 | - | |
| 17 | Ubiquitination | KIPFCDAKEEIRAGL CCCCCCHHHHHHHHH | 42.50 | - | |
| 26 | Phosphorylation | EIRAGLESSEGGGGP HHHHHHCCCCCCCCC | 38.44 | 30266825 | |
| 27 | Phosphorylation | IRAGLESSEGGGGPE HHHHHCCCCCCCCCC | 30.77 | 30266825 | |
| 136 | Ubiquitination | RDHRAHHKYSETDAD HHHHHHHCCCCCCCC | 40.37 | 21890473 | |
| 136 | Ubiquitination | RDHRAHHKYSETDAD HHHHHHHCCCCCCCC | 40.37 | 21890473 | |
| 136 (in isoform 1) | Ubiquitination | - | 40.37 | 21890473 | |
| 136 (in isoform 2) | Ubiquitination | - | 40.37 | 21890473 | |
| 173 | Ubiquitination | DVIEKGRKLDVTDLL HHHHHCCCCCHHHHH | 58.68 | 2190698 | |
| 173 (in isoform 1) | Ubiquitination | - | 58.68 | 21890473 | |
| 173 (in isoform 2) | Ubiquitination | - | 58.68 | 21890473 | |
| 215 | Phosphorylation | PWYIWGESLWNSYFL CCHHHCHHHHHHHHH | 34.44 | 26074081 | |
| 219 | Phosphorylation | WGESLWNSYFLASIL HCHHHHHHHHHHHHH | 12.99 | 26074081 | |
| 220 | Phosphorylation | GESLWNSYFLASILR CHHHHHHHHHHHHHH | 10.21 | 26074081 | |
| 315 | Ubiquitination | TDRKRATKPMIEARK CCCHHCCHHHHHHHH | 31.44 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SCD5_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SCD5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SCD5_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SCD5_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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