TLCD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TLCD1_HUMAN
• UniProt AC: Q96CP7
• Protein Name: Calfacilitin
• Gene Name: TLCD1
• Organism: Homo sapiens (Human).
• Sequence Length: 247
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Calcium channel facilitator that increases calcium flux by generating a larger window current and slowing inactivation of the L-type CACNA1C/CaV1.2 channel. Regulation of intracellular calcium by Calfacilitin is required for neural plate formation (By similarity)..
• Protein Sequence: MPRLLHPALPLLLGATLTFRALRRALCRLPLPVHVRADPLRTWRWHNLLVSFAHSIVSGIWALLCVWQTPDMLVEIETAWSLSGYLLVCFSAGYFIHDTVDIVASGQTRASWEYLVHHVMAMGAFFSGIFWSSFVGGGVLTLLVEVSNIFLTIRMMMKISNAQDHLLYRVNKYVNLVMYFLFRLAPQAYLTHFFLRYVNQRTLGTFLLGILLMLDVMIIIYFSRLLRSDFCPEHVPKKQHKDKFLTE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
160	Phosphorylation	IRMMMKISNAQDHLL HHHHHHHCCHHHHHH	22.16	-
173	Phosphorylation	LLYRVNKYVNLVMYF HHHHHHHHHHHHHHH	6.86	26126808
179	Phosphorylation	KYVNLVMYFLFRLAP HHHHHHHHHHHHHCC	6.94	26126808
231	S-palmitoylation	RLLRSDFCPEHVPKK HHHCCCCCCCCCCHH	4.67	21044946

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TLCD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TLCD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TLCD1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TLCD1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.