MLEC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MLEC_HUMAN
• UniProt AC: Q14165
• Protein Name: Malectin
• Gene Name: MLEC
• Organism: Homo sapiens (Human).
• Sequence Length: 292
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
• Protein Description: Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity)..
• Protein Sequence: MLGAWAVEGTAVALLRLLLLLLPPAIRGPGLGVAGVAGAAGAGLPESVIWAVNAGGEAHVDVHGIHFRKDPLEGRVGRASDYGMKLPILRSNPEDQILYQTERYNEETFGYEVPIKEEGDYVLVLKFAEVYFAQSQQKVFDVRLNGHVVVKDLDIFDRVGHSTAHDEIIPMSIRKGKLSVQGEVSTFTGKLYIEFVKGYYDNPKVCALYIMAGTVDDVPKLQPHPGLEKKEEEEEEEEYDEGSNLKKQTNKNRVQSGPRTPNPYASDNSSLMFPILVAFGVFIPTLFCLCRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
85	2-Hydroxyisobutyrylation	RASDYGMKLPILRSN CHHHCCCCCCEECCC	46.91	-
99	Phosphorylation	NPEDQILYQTERYNE CHHHCEEEEEECCCC	18.28	28152594
101	O-linked_Glycosylation	EDQILYQTERYNEET HHCEEEEEECCCCCC	14.63	OGP
101	Phosphorylation	EDQILYQTERYNEET HHCEEEEEECCCCCC	14.63	28152594
104	Phosphorylation	ILYQTERYNEETFGY EEEEEECCCCCCCCE	22.24	21406692
108	Phosphorylation	TERYNEETFGYEVPI EECCCCCCCCEEEEC	19.04	21406692
111	Phosphorylation	YNEETFGYEVPIKEE CCCCCCCEEEECCCC	15.01	21406692
121	Phosphorylation	PIKEEGDYVLVLKFA ECCCCCCEEEEEEEE	13.41	-
131	Phosphorylation	VLKFAEVYFAQSQQK EEEEEEEEEECCCCE	5.68	-
151	Acetylation	LNGHVVVKDLDIFDR ECCEEEECCCCCCCC	40.75	26051181
179	Phosphorylation	SIRKGKLSVQGEVST EEECCCEEEEEEEEE	18.84	20068231
185	Phosphorylation	LSVQGEVSTFTGKLY EEEEEEEEECCEEEE	17.32	25954137
186	Phosphorylation	SVQGEVSTFTGKLYI EEEEEEEECCEEEEE	30.32	20068231
188	Phosphorylation	QGEVSTFTGKLYIEF EEEEEECCEEEEEEE	33.23	20068231
192	Phosphorylation	STFTGKLYIEFVKGY EECCEEEEEEEHHCC	11.24	25954137
199	Phosphorylation	YIEFVKGYYDNPKVC EEEEHHCCCCCHHEE	11.26	-
200	Phosphorylation	IEFVKGYYDNPKVCA EEEHHCCCCCHHEEE	20.22	-
230	Acetylation	PHPGLEKKEEEEEEE CCCCCCHHHHHHHHH	62.07	26051181
239	Phosphorylation	EEEEEEEYDEGSNLK HHHHHHHCCCCCCHH	23.68	25159151
246	Ubiquitination	YDEGSNLKKQTNKNR CCCCCCHHHHCCCCC	47.27	21906983
246	Acetylation	YDEGSNLKKQTNKNR CCCCCCHHHHCCCCC	47.27	26051181
268	N-linked_Glycosylation	PNPYASDNSSLMFPI CCCCCCCCCCCHHHH	30.88	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MLEC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MLEC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MLEC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RS16_HUMAN	RPS16	physical	22939629
CATD_HUMAN	CTSD	physical	26344197
RBM8A_HUMAN	RBM8A	physical	26344197
STT3B_HUMAN	STT3B	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.