| UniProt ID | CAC1A_HUMAN | |
|---|---|---|
| UniProt AC | O00555 | |
| Protein Name | Voltage-dependent P/Q-type calcium channel subunit alpha-1A | |
| Gene Name | CACNA1A | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 2505 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . |
|
| Protein Description | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).. | |
| Protein Sequence | MARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENRNNNTNKSRAAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARRPWAGSQEAELSREGPYGRESDHHAREGSLEQPGFWEGEAERGKAGDPHRRHVHRQGGSRESRSGSPRTGADGEHRRHRAHRRPGEEGPEDKAERRARHREGSRPARGGEGEGEGPDGGERRRRHRHGAPATYEGDARREDKERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDIDNMKNNKLATAESAAPHGSLGHAGLPQSPAKMGNSTDPGPMLAIPAMATNPQNAASRRTPNNPGNPSNPGPPKTPENSLIVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQDRTPLMFQRMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKESPSWVTQRAQEMFQKTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPAENQRRRGRPRGNNLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRHHQRRRDRSHRASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQERGRPKDRKHRQHHHHHHHHHHPPPPDKDRYAQERPDHGRARARDQRWSRSPSEGREHMAHRQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPSTPRPHVSYSPVIRKAGGSGPPQQQQQQQQQQQAVARPGRAATSGPRRYPGPTAEPLAGDRPPTGGHSSGRSPRMERRVPGPARSESPRACRHGGARWPASGPHVSEGPPGPRHHGYYRGSDYDEADGPGSGGGEEAMAGAYDAPPPVRHASSGATGRSPRTPRASGPACASPSRHGRRLPNGYYPAHGLARPRGPGSRKGLHEPYSESDDDWC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 12 | Phosphorylation | GDEMPARYGGGGSGA CCCCCCCCCCCCCCC | 23.41 | 28674151 | |
| 27 | Phosphorylation | AAGVVVGSGGGRGAG CCEEEECCCCCCCCC | 23.74 | 28674151 | |
| 204 (in isoform 2) | Ubiquitination | - | 49.91 | - | |
| 211 | Phosphorylation | KLVSGIPSLQVVLKS HHHCCCCHHHHHHHH | 29.52 | - | |
| 283 | N-linked_Glycosylation | EPARTCPNGTKCQPY CCCCCCCCCCCCCCC | 73.28 | UniProtKB CARBOHYD | |
| 378 | Ubiquitination | ENRRAFLKLRRQQQI HHHHHHHHHHHHHHH | 33.23 | - | |
| 392 | Phosphorylation | IERELNGYMEWISKA HHHHHHHHHHHHHHH | 7.26 | 29978859 | |
| 397 | Phosphorylation | NGYMEWISKAEEVIL HHHHHHHHHHHEEEE | 27.21 | 29978859 | |
| 409 | Phosphorylation | VILAEDETDGEQRHP EEEECCCCCCCCCCC | 62.72 | 24076635 | |
| 447 | Phosphorylation | EDQLADIASVGSPFA HHHHHHHHHCCCHHH | 9.94 | - | |
| 448 | Phosphorylation | DQLADIASVGSPFAR HHHHHHHHCCCHHHH | 27.61 | 22617229 | |
| 450 | Phosphorylation | LADIASVGSPFARAS HHHHHHCCCHHHHHH | 27.40 | - | |
| 451 | Phosphorylation | ADIASVGSPFARASI HHHHHCCCHHHHHHH | 18.06 | 22617229 | |
| 539 | Phosphorylation | SEMFIKMYGLGTRPY HHHHHHHHCCCCCCC | 12.28 | 30622161 | |
| 749 | Phosphorylation | KAKEVAEVSPLSAAN HHHHHHHHCCCCHHH | 5.28 | - | |
| 750 | Phosphorylation | AKEVAEVSPLSAANM HHHHHHHCCCCHHHH | 16.19 | 24076635 | |
| 752 | Phosphorylation | EVAEVSPLSAANMSI HHHHHCCCCHHHHHH | 4.19 | - | |
| 753 | Phosphorylation | VAEVSPLSAANMSIA HHHHCCCCHHHHHHH | 28.81 | - | |
| 789 | Phosphorylation | MRKQNLLASREALYN HHHHHHHHHHHHHHH | 15.09 | - | |
| 790 | Phosphorylation | RKQNLLASREALYNE HHHHHHHHHHHHHHC | 30.53 | - | |
| 910 | Phosphorylation | DHHAREGSLEQPGFW CCCCCCCCCCCCCCC | 24.79 | - | |
| 946 | Phosphorylation | GSRESRSGSPRTGAD CCCCCCCCCCCCCCC | 40.33 | - | |
| 947 | Phosphorylation | SRESRSGSPRTGADG CCCCCCCCCCCCCCC | 16.68 | 22817900 | |
| 948 | Methylation | RESRSGSPRTGADGE CCCCCCCCCCCCCCC | 41.18 | - | |
| 949 | Methylation | ESRSGSPRTGADGEH CCCCCCCCCCCCCCC | 47.71 | - | |
| 956 | Methylation | RTGADGEHRRHRAHR CCCCCCCCHHHHCCC | 37.29 | - | |
| 957 | Methylation | TGADGEHRRHRAHRR CCCCCCCHHHHCCCC | 31.62 | - | |
| 1014 | Phosphorylation | RHGAPATYEGDARRE CCCCCCCCCCCCCHH | 21.74 | 22817900 | |
| 1046 | Phosphorylation | PVSGPNLSTTRPIQQ CCCCCCCCCCCCCCC | 34.08 | 29255136 | |
| 1047 | Phosphorylation | VSGPNLSTTRPIQQD CCCCCCCCCCCCCCC | 29.95 | 29255136 | |
| 1048 | Phosphorylation | SGPNLSTTRPIQQDL CCCCCCCCCCCCCCC | 30.95 | 29255136 | |
| 1084 | Phosphorylation | AESAAPHGSLGHAGL HHHHCCCCCCCCCCC | 24.41 | - | |
| 1085 | Phosphorylation | ESAAPHGSLGHAGLP HHHCCCCCCCCCCCC | 28.30 | - | |
| 1093 | Phosphorylation | LGHAGLPQSPAKMGN CCCCCCCCCCCCCCC | 68.07 | - | |
| 1094 | Phosphorylation | GHAGLPQSPAKMGNS CCCCCCCCCCCCCCC | 25.53 | 25307156 | |
| 1102 | Phosphorylation | PAKMGNSTDPGPMLA CCCCCCCCCCCCCCC | 50.65 | 23532336 | |
| 1121 | Phosphorylation | ATNPQNAASRRTPNN CCCCCCHHHCCCCCC | 15.89 | - | |
| 1122 | Phosphorylation | TNPQNAASRRTPNNP CCCCCHHHCCCCCCC | 21.64 | 24275569 | |
| 1125 | Phosphorylation | QNAASRRTPNNPGNP CCHHHCCCCCCCCCC | 29.29 | 23312004 | |
| 1133 | Phosphorylation | PNNPGNPSNPGPPKT CCCCCCCCCCCCCCC | 60.71 | 23312004 | |
| 1140 | Phosphorylation | SNPGPPKTPENSLIV CCCCCCCCCCCCEEE | 41.42 | 23312004 | |
| 1144 | Phosphorylation | PPKTPENSLIVTNPS CCCCCCCCEEEECCC | 20.15 | 23312004 | |
| 1148 | Phosphorylation | PENSLIVTNPSGTQT CCCCEEEECCCCCCC | 34.12 | 23312004 | |
| 1151 | Phosphorylation | SLIVTNPSGTQTNSA CEEEECCCCCCCCCC | 57.45 | 23312004 | |
| 1153 | Phosphorylation | IVTNPSGTQTNSAKT EEECCCCCCCCCCCC | 36.24 | 23312004 | |
| 1155 | Phosphorylation | TNPSGTQTNSAKTAR ECCCCCCCCCCCCCC | 30.86 | 23312004 | |
| 1157 | Phosphorylation | PSGTQTNSAKTARKP CCCCCCCCCCCCCCC | 34.23 | 23312004 | |
| 1337 | Ubiquitination | FTGNSKGKDINTIKS HCCCCCCCCHHHHHH | 60.20 | - | |
| 1342 | Ubiquitination | KGKDINTIKSLRVLR CCCCHHHHHHHHHHH | 2.17 | - | |
| 1343 | Ubiquitination | GKDINTIKSLRVLRV CCCHHHHHHHHHHHH | 41.20 | - | |
| 1343 (in isoform 1) | Ubiquitination | - | 41.20 | 21906983 | |
| 1343 (in isoform 2) | Ubiquitination | - | 41.20 | 21906983 | |
| 1343 (in isoform 3) | Ubiquitination | - | 41.20 | 21906983 | |
| 1343 (in isoform 4) | Ubiquitination | - | 41.20 | 21906983 | |
| 1343 (in isoform 5) | Ubiquitination | - | 41.20 | 21906983 | |
| 1343 (in isoform 6) | Ubiquitination | - | 41.20 | 21906983 | |
| 1421 | Phosphorylation | EKDCRGKYLLYEKNE HHHHCCCEEEEECCC | 12.55 | 22817900 | |
| 1424 | Phosphorylation | CRGKYLLYEKNEVKA HCCCEEEEECCCCCC | 23.43 | 22817900 | |
| 1426 | Ubiquitination | GKYLLYEKNEVKARD CCEEEEECCCCCCCC | 44.87 | - | |
| 1525 | Phosphorylation | GDKMMEEYSLEKNER HHHHHHHHCCCCCHH | 12.78 | 29083192 | |
| 1526 | Phosphorylation | DKMMEEYSLEKNERA HHHHHHHCCCCCHHH | 33.07 | 29083192 | |
| 1541 | Ubiquitination | CIDFAISAKPLTRHM HHHHHHHCCCCCCCC | 16.04 | - | |
| 1542 | Ubiquitination | IDFAISAKPLTRHMP HHHHHHCCCCCCCCC | 33.50 | 2190698 | |
| 1542 (in isoform 1) | Ubiquitination | - | 33.50 | 21906983 | |
| 1542 (in isoform 2) | Ubiquitination | - | 33.50 | 21906983 | |
| 1542 (in isoform 3) | Ubiquitination | - | 33.50 | 21906983 | |
| 1542 (in isoform 4) | Ubiquitination | - | 33.50 | 21906983 | |
| 1542 (in isoform 5) | Ubiquitination | - | 33.50 | 21906983 | |
| 1542 (in isoform 6) | Ubiquitination | - | 33.50 | 21906983 | |
| 1552 | Ubiquitination | TRHMPQNKQSFQYRM CCCCCCCHHHHHHHH | 41.91 | - | |
| 1586 | Acetylation | NTIVLMMKFYGASVA HHHHHHHHHHCCHHH | 22.82 | 11688103 | |
| 1677 | Phosphorylation | KLLRQGYTIRILLWT HHHHCCCCHHHHHHH | 15.59 | 24719451 | |
| 1764 | Phosphorylation | AWHNIMLSCLSGKPC HHHHHHHHHHCCCCC | 8.81 | 30576142 | |
| 1822 | Phosphorylation | EYLTRDSSILGPHHL HHHCCCCCCCCCCCH | 26.56 | - | |
| 1849 | Phosphorylation | AAWGRMPYLDMYQML HHHCCCCHHHHHHHH | 13.14 | 24043423 | |
| 1867 (in isoform 2) | Ubiquitination | - | 57.13 | - | |
| 1868 (in isoform 2) | Ubiquitination | - | 43.59 | - | |
| 1935 | Phosphorylation | MAIWPNLSQKTLDLL HHHCCCCCHHHHCEE | 35.95 | - | |
| 1983 | Phosphorylation | AMREEQDRTPLMFQR HHHHHHCCCCCCCEE | 37.63 | - | |
| 1984 | Phosphorylation | MREEQDRTPLMFQRM HHHHHCCCCCCCEEC | 29.12 | - | |
| 1995 | Phosphorylation | FQRMEPPSPTQEGGP CEECCCCCCCCCCCC | 51.82 | 24076635 | |
| 2010 | Phosphorylation | GQNALPSTQLDPGGA CCCCCCCCCCCCCCC | 31.07 | 25307156 | |
| 2046 | Phosphorylation | MFQKTGTWSPEQGPP HHHHHCCCCCCCCCC | 17.15 | - | |
| 2047 | Phosphorylation | FQKTGTWSPEQGPPT HHHHCCCCCCCCCCC | 20.56 | - | |
| 2064 | Phosphorylation | PNSQPNSQSVEMREM CCCCCCCCCCCHHHC | 59.13 | - | |
| 2065 | Phosphorylation | NSQPNSQSVEMREMG CCCCCCCCCCHHHCC | 21.62 | - | |
| 2076 | Phosphorylation | REMGRDGYSDSEHYL HHCCCCCCCCCCCCC | 17.37 | - | |
| 2077 | Phosphorylation | EMGRDGYSDSEHYLP HCCCCCCCCCCCCCC | 39.94 | - | |
| 2078 | Phosphorylation | MGRDGYSDSEHYLPM CCCCCCCCCCCCCCC | 49.95 | - | |
| 2079 | Phosphorylation | GRDGYSDSEHYLPME CCCCCCCCCCCCCCC | 21.97 | - | |
| 2093 | Phosphorylation | EGQGRAASMPRLPAE CCCCCCCCCCCCCHH | 28.47 | 24719451 | |
| 2098 | Phosphorylation | AASMPRLPAENQRRR CCCCCCCCHHHHHHC | 38.52 | 24719451 | |
| 2103 (in isoform 5) | Phosphorylation | - | 41.67 | 22210691 | |
| 2103 (in isoform 6) | Phosphorylation | - | 41.67 | 22210691 | |
| 2105 (in isoform 5) | Phosphorylation | - | 47.89 | 25627689 | |
| 2105 (in isoform 6) | Phosphorylation | - | 47.89 | 25627689 | |
| 2107 (in isoform 5) | Phosphorylation | - | 18.87 | 22210691 | |
| 2107 (in isoform 6) | Phosphorylation | - | 18.87 | 22210691 | |
| 2108 (in isoform 5) | Phosphorylation | - | 51.89 | 21815630 | |
| 2108 (in isoform 6) | Phosphorylation | - | 51.89 | 21815630 | |
| 2113 (in isoform 5) | Phosphorylation | - | 5.76 | 27067055 | |
| 2113 (in isoform 6) | Phosphorylation | - | 5.76 | 27067055 | |
| 2115 | Phosphorylation | PRGNNLSTISDTSPM CCCCCCCCCCCCCCC | 27.89 | - | |
| 2117 | Phosphorylation | GNNLSTISDTSPMKR CCCCCCCCCCCCCCC | 34.62 | - | |
| 2119 | Phosphorylation | NLSTISDTSPMKRSA CCCCCCCCCCCCCCH | 28.12 | - | |
| 2120 | Phosphorylation | LSTISDTSPMKRSAS CCCCCCCCCCCCCHH | 28.17 | 25307156 | |
| 2120 (in isoform 2) | O-linked_Glycosylation | - | 28.17 | 30379171 | |
| 2123 (in isoform 2) | Ubiquitination | - | 46.73 | - | |
| 2125 | Phosphorylation | DTSPMKRSASVLGPK CCCCCCCCHHHHCCC | 21.27 | - | |
| 2127 | Phosphorylation | SPMKRSASVLGPKAR CCCCCCHHHHCCCCC | 21.08 | 29083192 | |
| 2139 | Phosphorylation | KARRLDDYSLERVPP CCCCCCCCCCCCCCC | 18.15 | 23186163 | |
| 2140 | Phosphorylation | ARRLDDYSLERVPPE CCCCCCCCCCCCCCH | 30.65 | 23186163 | |
| 2193 | Phosphorylation | TQSGDLPSKERDQER CCCCCCCCHHHHHHC | 55.21 | 24719451 | |
| 2247 | Phosphorylation | RARDQRWSRSPSEGR HHHHCCCCCCCCCCH | 25.68 | 30108239 | |
| 2249 | Phosphorylation | RDQRWSRSPSEGREH HHCCCCCCCCCCHHH | 27.54 | 30108239 | |
| 2251 | Phosphorylation | QRWSRSPSEGREHMA CCCCCCCCCCHHHCC | 54.66 | 30108239 | |
| 2263 | Phosphorylation | HMAHRQGSSSVSGSP HCCCCCCCCCCCCCC | 15.88 | 30108239 | |
| 2264 | Phosphorylation | MAHRQGSSSVSGSPA CCCCCCCCCCCCCCC | 41.40 | 30108239 | |
| 2265 | Phosphorylation | AHRQGSSSVSGSPAP CCCCCCCCCCCCCCC | 23.23 | 30108239 | |
| 2267 | Phosphorylation | RQGSSSVSGSPAPST CCCCCCCCCCCCCCC | 35.19 | 30108239 | |
| 2268 | Phosphorylation | QGSSSVSGSPAPSTS CCCCCCCCCCCCCCC | 35.18 | - | |
| 2269 | Phosphorylation | GSSSVSGSPAPSTSG CCCCCCCCCCCCCCC | 15.47 | 30108239 | |
| 2274 | Phosphorylation | SGSPAPSTSGTSTPR CCCCCCCCCCCCCCC | 30.07 | 27251275 | |
| 2275 | Phosphorylation | GSPAPSTSGTSTPRR CCCCCCCCCCCCCCC | 44.40 | 22210691 | |
| 2279 | Phosphorylation | PSTSGTSTPRRGRRQ CCCCCCCCCCCCCCC | 22.20 | - | |
| 2290 | Phosphorylation | GRRQLPQTPSTPRPH CCCCCCCCCCCCCCC | 19.78 | 28348404 | |
| 2295 | Phosphorylation | PQTPSTPRPHVSYSP CCCCCCCCCCCCCCC | 33.76 | 27251275 | |
| 2299 | Phosphorylation | STPRPHVSYSPVIRK CCCCCCCCCCCCHHH | 19.50 | 27251275 | |
| 2300 | Phosphorylation | TPRPHVSYSPVIRKA CCCCCCCCCCCHHHC | 18.86 | 23312004 | |
| 2301 | Phosphorylation | PRPHVSYSPVIRKAG CCCCCCCCCCHHHCC | 12.75 | 23312004 | |
| 2334 | Phosphorylation | ARPGRAATSGPRRYP HCCCCHHCCCCCCCC | 32.98 | 23403867 | |
| 2335 | Phosphorylation | RPGRAATSGPRRYPG CCCCHHCCCCCCCCC | 41.91 | 23403867 | |
| 2355 | Phosphorylation | LAGDRPPTGGHSSGR CCCCCCCCCCCCCCC | 59.48 | 28348404 | |
| 2359 | Phosphorylation | RPPTGGHSSGRSPRM CCCCCCCCCCCCCCC | 37.45 | 28348404 | |
| 2360 | Phosphorylation | PPTGGHSSGRSPRME CCCCCCCCCCCCCCC | 32.33 | 24719451 | |
| 2363 | Phosphorylation | GGHSSGRSPRMERRV CCCCCCCCCCCCCCC | 22.00 | 28348404 | |
| 2366 | Phosphorylation | SSGRSPRMERRVPGP CCCCCCCCCCCCCCC | 5.51 | 27251275 | |
| 2367 | Phosphorylation | SGRSPRMERRVPGPA CCCCCCCCCCCCCCC | 38.32 | 24719451 | |
| 2376 | Phosphorylation | RVPGPARSESPRACR CCCCCCCCCCCCHHC | 44.53 | 30108239 | |
| 2378 | Phosphorylation | PGPARSESPRACRHG CCCCCCCCCCHHCCC | 22.41 | 30108239 | |
| 2414 | Phosphorylation | GYYRGSDYDEADGPG CCCCCCCCCCCCCCC | 19.85 | 23532336 | |
| 2422 | Phosphorylation | DEADGPGSGGGEEAM CCCCCCCCCCHHHHC | 37.08 | - | |
| 2433 | Phosphorylation | EEAMAGAYDAPPPVR HHHCCCCCCCCCCCC | 16.24 | 23532336 | |
| 2450 | Phosphorylation | SSGATGRSPRTPRAS CCCCCCCCCCCCCCC | 21.78 | 22964224 | |
| 2451 | Phosphorylation | SGATGRSPRTPRASG CCCCCCCCCCCCCCC | 42.69 | - | |
| 2463 | Phosphorylation | ASGPACASPSRHGRR CCCCCCCCCCCCCCC | 24.24 | 28857561 | |
| 2464 | Phosphorylation | SGPACASPSRHGRRL CCCCCCCCCCCCCCC | 19.50 | - | |
| 2465 | Phosphorylation | GPACASPSRHGRRLP CCCCCCCCCCCCCCC | 34.12 | 29083192 | |
| 2470 | Phosphorylation | SPSRHGRRLPNGYYP CCCCCCCCCCCCCCC | 60.12 | 24719451 | |
| 2498 | Phosphorylation | KGLHEPYSESDDDWC CCCCCCCCCCCCCCC | 41.14 | 30108239 | |
| 2500 | Phosphorylation | LHEPYSESDDDWC-- CCCCCCCCCCCCC-- | 40.16 | 30108239 | |
| 2505 | Phosphorylation | SESDDDWC------- CCCCCCCC------- | 5.27 | 27251275 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CAC1A_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CAC1A_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CAC1A_HUMAN !! | ||||||
| Kegg Disease | |
|---|---|
| H00063 | Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) |
| H00749 | Episodic ataxias |
| H00775 | Familial or sporadic hemiplegic migraine |
| OMIM Disease | |
| 183086 | Spinocerebellar ataxia 6 (SCA6) |
| 141500 | Migraine, familial hemiplegic, 1 (FHM1) |
| 108500 | Episodic ataxia 2 (EA2) |
| Kegg Drug | |
| There are no disease associations of PTM sites. | |
| DrugBank | |
| DB01244 | Bepridil |
| DB00836 | Loperamide |
| DB00230 | Pregabalin |
| DB00421 | Spironolactone |
| DB00661 | Verapamil |
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