FBLN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBLN3_HUMAN
• UniProt AC: Q12805
• Protein Name: EGF-containing fibulin-like extracellular matrix protein 1
• Gene Name: EFEMP1
• Organism: Homo sapiens (Human).
• Sequence Length: 493
• Subcellular Localization: Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Localizes to the lamina propria underneath the olfactory epithelium..
• Protein Description: Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth..
• Protein Sequence: MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSSVLRLTIIVGPFSF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MLKALFLTMLTLALV CHHHHHHHHHHHHHH	11.64	26074081
11	Phosphorylation	ALFLTMLTLALVKSQ HHHHHHHHHHHHHCC	10.12	26074081
33	Phosphorylation	YTQCTDGYEWDPVRQ EEECCCCCCCCHHHH	19.36	-
88	O-linked_Glycosylation	NEQPQQETQPAEGTS CCCCCCCCCCCCCCC	35.20	OGP
98	O-linked_Glycosylation	AEGTSGATTGVVAAS CCCCCCCCHHHEEEE	27.84	OGP
105	O-linked_Glycosylation	TTGVVAASSMATSGV CHHHEEEECCCCCCC	15.77	OGP
106	O-linked_Glycosylation	TGVVAASSMATSGVL HHHEEEECCCCCCCC	14.01	OGP
109	O-linked_Glycosylation	VAASSMATSGVLPGG EEEECCCCCCCCCCC	19.85	OGP
110	O-linked_Glycosylation	AASSMATSGVLPGGG EEECCCCCCCCCCCC	19.84	OGP
121	O-linked_Glycosylation	PGGGFVASAAAVAGP CCCCHHHCCHHHHCC	17.09	OGP
149	Ubiquitination	NPADPQRIPSNPSHR CCCCCCCCCCCHHHC	3.55	-
151	Phosphorylation	ADPQRIPSNPSHRIQ CCCCCCCCCHHHCCC	60.03	-
207	Ubiquitination	QCPPGYQKRGEQCVD CCCCCCCCCCCCCCC	54.62	-
249	N-linked_Glycosylation	GFQLAANNYTCVDIN CCEEECCCEEEEEHH	28.85	UniProtKB CARBOHYD
397	Phosphorylation	PQSIVYKYMSIRSDR CHHHHHHHHCCCCCC	4.38	-
408	Phosphorylation	RSDRSVPSDIFQIQA CCCCCCCCCCEEEEE	40.98	-
425	Phosphorylation	IYANTINTFRIKSGN EECCCCEEEEEECCC	15.50	-
442	Phosphorylation	GEFYLRQTSPVSAML CCEEEEECCCCCEEE	28.67	22210691
454	Phosphorylation	AMLVLVKSLSGPREH EEEEHHHHCCCCHHH	21.93	27135362
456	Phosphorylation	LVLVKSLSGPREHIV EEHHHHCCCCHHHEE	54.57	23312004
472	Phosphorylation	LEMLTVSSIGTFRTS EEEEEECCCCCCCCC	22.24	22210691
475	Phosphorylation	LTVSSIGTFRTSSVL EEECCCCCCCCCCEE	14.31	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBLN3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBLN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBLN3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SGTA_HUMAN	SGTA	physical	16189514
SOCS6_HUMAN	SOCS6	physical	21988832
TNIP1_HUMAN	TNIP1	physical	21988832
KHDR1_HUMAN	KHDRBS1	physical	21988832
SGTA_HUMAN	SGTA	physical	25416956
TRAF2_HUMAN	TRAF2	physical	25416956
BAG6_HUMAN	BAG6	physical	25416956
RIC8A_HUMAN	RIC8A	physical	25416956
TXND5_HUMAN	TXNDC5	physical	25416956
SGTA_HUMAN	SGTA	physical	21516116
ZN747_HUMAN	ZNF747	physical	28514442
ZN628_HUMAN	ZNF628	physical	28514442
ZN398_HUMAN	ZNF398	physical	28514442
ZN627_HUMAN	ZNF627	physical	28514442
ZN408_HUMAN	ZNF408	physical	28514442
ZBTB9_HUMAN	ZBTB9	physical	28514442
ZN358_HUMAN	ZNF358	physical	28514442
ZN444_HUMAN	ZNF444	physical	28514442
ZN316_HUMAN	ZNF316	physical	28514442
ZN460_HUMAN	ZNF460	physical	28514442
ZN669_HUMAN	ZNF669	physical	28514442
Z324A_HUMAN	ZNF324	physical	28514442
ZN696_HUMAN	ZNF696	physical	28514442
LTBP1_HUMAN	LTBP1	physical	28514442
RPC7_HUMAN	POLR3G	physical	28514442
E4F1_HUMAN	E4F1	physical	28514442
RPC3_HUMAN	POLR3C	physical	28514442
ZSC21_HUMAN	ZSCAN21	physical	28514442
BIN2_HUMAN	BIN2	physical	28514442
ZN791_HUMAN	ZNF791	physical	28514442
ZN136_HUMAN	ZNF136	physical	28514442
ZN646_HUMAN	ZNF646	physical	28514442
FBLN1_HUMAN	FBLN1	physical	28514442
APOD_HUMAN	APOD	physical	28514442
ZN768_HUMAN	ZNF768	physical	28514442
EGFL7_HUMAN	EGFL7	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442
ZA2G_HUMAN	AZGP1	physical	28514442
CRAC1_HUMAN	CRTAC1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.