ZN646_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN646_HUMAN
• UniProt AC: O15015
• Protein Name: Zinc finger protein 646
• Gene Name: ZNF646
• Organism: Homo sapiens (Human).
• Sequence Length: 1829
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MEDTPPSLSCSDCQRHFPSLPELSRHRELLHPSPNQDSEEADSIPRPYRCQQCGRGYRHPGSLVNHRRTHETGLFPCTTCGKDFSNPMALKSHMRTHAPEGRRRHRPPRPKEATPHLQGETVSTDSWGQRLGSSEGWENQTKHTEETPDCESVPDPRAASGTWEDLPTRQREGLASHPGPEDGADGWGPSTNSARAPPLPIPASSLLSNLEQYLAESVVNFTGGQEPTQSPPAEEERRYKCSQCGKTYKHAGSLTNHRQSHTLGIYPCAICFKEFSNLMALKNHSRLHAQYRPYHCPHCPRVFRLPRELLEHQQSHEGERQEPRWEEKGMPTTNGHTDESSQDQLPSAQMLNGSAELSTSGELEDSGLEEYRPFRCGDCGRTYRHAGSLINHRKSHQTGVYPCSLCSKQLFNAAALKNHVRAHHRPRQGVGENGQPSVPPAPLLLAETTHKEEEDPTTTLDHRPYKCSECGRAYRHRGSLVNHRHSHRTGEYQCSLCPRKYPNLMALRNHVRVHCKAARRSADIGAEGAPSHLKVELPPDPVEAEAAPHTDQDHVCKHEEEATDITPAADKTAAHICSICGLLFEDAESLERHGLTHGAGEKENSRTETTMSPPRAFACRDCGKSYRHSGSLINHRQTHQTGDFSCGACAKHFHTMAAMKNHLRRHSRRRSRRHRKRAGGASGGREAKLLAAESWTRELEDNEGLESPQDPSGESPHGAEGNLESDGDCLQAESEGDKCGLERDETHFQGDKESGGTGEGLERKDASLLDNLDIPGEEGGGTHFCDSLTGVDEDQKPATGQPNSSSHSANAVTGWQAGAAHTCSDCGHSFPHATGLLSHRPCHPPGIYQCSLCPKEFDSLPALRSHFQNHRPGEATSAQPFLCCLCGMIFPGRAGYRLHRRQAHSSSGMTEGSEEEGEEEGVAEAAPARSPPLQLSEAELLNQLQREVEALDSAGYGHICGCCGQTYDDLGSLERHHQSQSSGTTADKAPSPLGVAGDAMEMVVDSVLEDIVNSVSGEGGDAKSQEGAGTPLGDSLCIQGGESLLEAQPRPFRCNQCGKTYRHGGSLVNHRKIHQTGDFLCPVCSRCYPNLAAYRNHLRNHPRCKGSEPQVGPIPEAAGSSELQVGPIPEGGSNKPQHMAEEGPGQAEVEKLQEELKVEPLEEVARVKEEVWEETTVKGEEIEPRLETAEKGCQTEASSERPFSCEVCGRSYKHAGSLINHRQSHQTGHFGCQACSKGFSNLMSLKNHRRIHADPRRFRCSECGKAFRLRKQLASHQRVHMERRGGGGTRKATREDRPFRCGQCGRTYRHAGSLLNHRRSHETGQYSCPTCPKTYSNRMALKDHQRLHSENRRRRAGRSRRTAVRCALCGRSFPGRGSLERHLREHEETEREPANGQGGLDGTAASEANLTGSQGLETQLGGAEPVPHLEDGVPRPGERSQSPIRAASSEAPEPLSWGAGKAGGWPVGGGLGNHSGGWVPQFLTRSEEPEDSVHRSPCHAGDCQLNGPTLSHMDSWDNRDNSSQLQPGSHSSCSQCGKTYCQSGSLLNHNTNKTDRHYCLLCSKEFLNPVATKSHSHNHIDAQTFACPDCGKAFESHQELASHLQAHARGHSQVPAQMEEARDPKAGTGEDQVVLPGQGKAQEAPSETPRGPGESVERARGGQAVTSMAAEDKERPFRCTQCGRSYRHAGSLLNHQKAHTTGLYPCSLCPKLLPNLLSLKNHSRTHTDPKRHCCSICGKAFRTAARLEGHGRVHAPREGPFTCPHCPRHFRRRISFVQHQQQHQEEWTVAGSGRGHEGSQEEVGTQWRGKSSPKVGGGARSERREPRGF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	HRELLHPSPNQDSEE CHHHHCCCCCCCHHH	26.24	26055452
38	Phosphorylation	HPSPNQDSEEADSIP CCCCCCCHHHHHCCC	27.80	26055452
62	Phosphorylation	RGYRHPGSLVNHRRT CCCCCCCCCCCCCCC	33.33	23312004
92	O-linked_Glycosylation	SNPMALKSHMRTHAP CCHHHHHHHHHHCCC	24.30	30379171
121	Phosphorylation	TPHLQGETVSTDSWG CCCCCCCEEECCCHH	26.95	24275569
124	Phosphorylation	LQGETVSTDSWGQRL CCCCEEECCCHHHHC	29.71	23401153
133	Phosphorylation	SWGQRLGSSEGWENQ CHHHHCCCCCCCCCC	29.79	29978859
134	Phosphorylation	WGQRLGSSEGWENQT HHHHCCCCCCCCCCC	38.03	29978859
160	Phosphorylation	VPDPRAASGTWEDLP CCCCCCCCCCHHCCC	35.45	28555341
204	Phosphorylation	PPLPIPASSLLSNLE CCCCCCHHHHHHHHH	19.03	21406692
205	Phosphorylation	PLPIPASSLLSNLEQ CCCCCHHHHHHHHHH	35.12	21406692
208	Phosphorylation	IPASSLLSNLEQYLA CCHHHHHHHHHHHHH	44.66	21406692
213	Phosphorylation	LLSNLEQYLAESVVN HHHHHHHHHHHHCHH	9.86	21406692
217	Phosphorylation	LEQYLAESVVNFTGG HHHHHHHHCHHCCCC	26.26	21406692
222	Phosphorylation	AESVVNFTGGQEPTQ HHHCHHCCCCCCCCC	34.89	21406692
228	Phosphorylation	FTGGQEPTQSPPAEE CCCCCCCCCCCCHHH	40.71	21406692
230	Phosphorylation	GGQEPTQSPPAEEER CCCCCCCCCCHHHHH	35.02	21406692
315	Phosphorylation	ELLEHQQSHEGERQE HHHHHHHCCCCCCCC	19.55	28555341
388	Phosphorylation	RTYRHAGSLINHRKS CCEECHHHHHCCCHH	27.19	24719451
398	Phosphorylation	NHRKSHQTGVYPCSL CCCHHCCCCCCCHHH	24.16	-
451	Sumoylation	LLAETTHKEEEDPTT EEEECCCCCCCCCCC	65.80	28112733
486	Phosphorylation	SLVNHRHSHRTGEYQ CCCCCCCCCCCCCEE	18.02	17081983
495	Phosphorylation	RTGEYQCSLCPRKYP CCCCEEECCCCCCCC	19.92	-
521	Phosphorylation	HCKAARRSADIGAEG HHHHHHHCCCCCCCC	25.41	25159151
534	Sumoylation	EGAPSHLKVELPPDP CCCCCCCEEECCCCC	28.39	28112733
557	Sumoylation	TDQDHVCKHEEEATD CCCCCCCCCHHHCCC	53.62	28112733
566	Phosphorylation	EEEATDITPAADKTA HHHCCCCCCCCHHHH	15.08	25159151
607	Phosphorylation	GEKENSRTETTMSPP CCCCCCCCCCCCCCC	37.19	23403867
609	Phosphorylation	KENSRTETTMSPPRA CCCCCCCCCCCCCCE	27.47	25850435
610	Phosphorylation	ENSRTETTMSPPRAF CCCCCCCCCCCCCEE	14.93	23403867
612	Phosphorylation	SRTETTMSPPRAFAC CCCCCCCCCCCEEEE	29.66	25218447
629	Phosphorylation	CGKSYRHSGSLINHR CCCCCCCCCCCCCCC	22.52	28555341
631	Phosphorylation	KSYRHSGSLINHRQT CCCCCCCCCCCCCCC	29.14	28555341
688	Sumoylation	ASGGREAKLLAAESW CCCHHHHHHHHHHHH	39.00	28112733
688	Ubiquitination	ASGGREAKLLAAESW CCCHHHHHHHHHHHH	39.00	29967540
707	Phosphorylation	EDNEGLESPQDPSGE CCCCCCCCCCCCCCC	32.67	30576142
712	Phosphorylation	LESPQDPSGESPHGA CCCCCCCCCCCCCCC	64.58	30576142
715	Phosphorylation	PQDPSGESPHGAEGN CCCCCCCCCCCCCCC	26.23	30576142
725	Phosphorylation	GAEGNLESDGDCLQA CCCCCCCCCCCCEEC	50.49	30576142
859	Phosphorylation	LCPKEFDSLPALRSH CCCHHHCCHHHHHHH	41.39	24719451
907	Phosphorylation	RRQAHSSSGMTEGSE HHHCCCCCCCCCCCH	35.28	25921289
910	Phosphorylation	AHSSSGMTEGSEEEG CCCCCCCCCCCHHHC	40.49	30576142
913	Phosphorylation	SSGMTEGSEEEGEEE CCCCCCCCHHHCHHC	35.29	24719451
930	Phosphorylation	AEAAPARSPPLQLSE HHCCCCCCCCCCCCH	32.73	29255136
936	Phosphorylation	RSPPLQLSEAELLNQ CCCCCCCCHHHHHHH	23.07	23663014
972	Phosphorylation	QTYDDLGSLERHHQS CCHHHHHHHHHHCCC	34.06	21815630
991	Phosphorylation	TTADKAPSPLGVAGD CCCCCCCCCCCCCHH	37.30	25159151
1006	Phosphorylation	AMEMVVDSVLEDIVN HHHHHHHHHHHHHHH	19.59	17081983
1030	Phosphorylation	KSQEGAGTPLGDSLC CCCCCCCCCCCCCEE	18.14	24719451
1054	S-palmitoylation	AQPRPFRCNQCGKTY CCCCCCCCCCCCCEE	4.17	29575903
1057	S-palmitoylation	RPFRCNQCGKTYRHG CCCCCCCCCCEEECC	3.62	29575903
1066	Phosphorylation	KTYRHGGSLVNHRKI CEEECCCCCCCCCHH	33.46	24719451
1157	Sumoylation	EKLQEELKVEPLEEV HHHHHHHCCCCHHHH	48.08	28112733
1157	Sumoylation	EKLQEELKVEPLEEV HHHHHHHCCCCHHHH	48.08	-
1168	Sumoylation	LEEVARVKEEVWEET HHHHHHHHHHHHHHE	42.47	28112733
1168	Sumoylation	LEEVARVKEEVWEET HHHHHHHHHHHHHHE	42.47	-
1176	O-linked_Glycosylation	EEVWEETTVKGEEIE HHHHHHEEECCCCCH	24.41	30379171
1178	Sumoylation	VWEETTVKGEEIEPR HHHHEEECCCCCHHH	59.52	28112733
1178	Sumoylation	VWEETTVKGEEIEPR HHHHEEECCCCCHHH	59.52	-
1213	Ubiquitination	EVCGRSYKHAGSLIN CCCCCCCCCHHHHHC	28.38	29967540
1217	Phosphorylation	RSYKHAGSLINHRQS CCCCCHHHHHCCCHH	27.19	24719451
1244	Phosphorylation	KGFSNLMSLKNHRRI CHHCCHHHHCCCCCC	39.08	25690035
1261	Phosphorylation	DPRRFRCSECGKAFR CCCCCCHHHHHHHHH	31.50	-
1313	Phosphorylation	RTYRHAGSLLNHRRS CCHHCHHHHHHCCCC	30.39	-
1378	Phosphorylation	RSFPGRGSLERHLRE CCCCCCCHHHHHHHH	26.20	17081983
1440	Phosphorylation	VPRPGERSQSPIRAA CCCCCCCCCCCCCCC	30.61	26329039
1442	Phosphorylation	RPGERSQSPIRAASS CCCCCCCCCCCCCCC	24.44	23401153
1448	Phosphorylation	QSPIRAASSEAPEPL CCCCCCCCCCCCCCC	27.94	28464451
1449	Phosphorylation	SPIRAASSEAPEPLS CCCCCCCCCCCCCCC	32.81	28464451
1456	Phosphorylation	SEAPEPLSWGAGKAG CCCCCCCCCCCCCCC	33.89	26074081
1496	Phosphorylation	PEDSVHRSPCHAGDC CCCCCCCCCCCCCCC	19.59	27080861
1522	Phosphorylation	SWDNRDNSSQLQPGS CCCCCCCCCCCCCCC	24.61	-
1523	Phosphorylation	WDNRDNSSQLQPGSH CCCCCCCCCCCCCCC	40.96	-
1612	Phosphorylation	QAHARGHSQVPAQME HHHHCCCCCCCHHHH	35.38	29255136
1646	Phosphorylation	GKAQEAPSETPRGPG CCCCCCCCCCCCCCC	62.24	27732954
1648	Phosphorylation	AQEAPSETPRGPGES CCCCCCCCCCCCCHH	23.71	21815630
1655	Phosphorylation	TPRGPGESVERARGG CCCCCCHHHHHHCCC	34.88	23532336
1660	Methylation	GESVERARGGQAVTS CHHHHHHCCCCCCCC	56.87	115920589
1666	Phosphorylation	ARGGQAVTSMAAEDK HCCCCCCCCCCCCCC	18.79	24719451
1667	Phosphorylation	RGGQAVTSMAAEDKE CCCCCCCCCCCCCCC	10.38	23532336
1700	Phosphorylation	LNHQKAHTTGLYPCS HCCCHHCCCCCCCCC	27.67	28555341
1701	Phosphorylation	NHQKAHTTGLYPCSL CCCHHCCCCCCCCCC	18.47	28555341
1718	Phosphorylation	KLLPNLLSLKNHSRT HHHHHHHHHCCCCCC	40.23	24719451
1723	Phosphorylation	LLSLKNHSRTHTDPK HHHHCCCCCCCCCCC	48.55	21406692
1725	Phosphorylation	SLKNHSRTHTDPKRH HHCCCCCCCCCCCCH	31.94	21406692
1727	Phosphorylation	KNHSRTHTDPKRHCC CCCCCCCCCCCCHHH	54.08	21406692
1775	Phosphorylation	RHFRRRISFVQHQQQ HHHHHHHHHHHHHHH	19.97	27251275
1775 (in isoform 2)	Phosphorylation	-	19.97	27251275
1799	Phosphorylation	SGRGHEGSQEEVGTQ CCCCCCCCHHHCCCC	31.28	23663014
1812 (in isoform 2)	Phosphorylation	-	32.02	28348404
1814 (in isoform 2)	Phosphorylation	-	56.30	28348404
1815	Phosphorylation	RGKSSPKVGGGARSE CCCCCCCCCCCCCCC	11.06	24719451
1815 (in isoform 2)	Phosphorylation	-	11.06	24719451
1821 (in isoform 2)	Phosphorylation	-	34.62	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN646_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN646_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN646_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NINL_HUMAN	NINL	physical	16189514
MDFI_HUMAN	MDFI	physical	19060904
EMSY_HUMAN	C11orf30	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.