ZN136_HUMAN - dbPTM
ZN136_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZN136_HUMAN
UniProt AC P52737
Protein Name Zinc finger protein 136
Gene Name ZNF136
Organism Homo sapiens (Human).
Sequence Length 540
Subcellular Localization Nucleus .
Protein Description May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain..
Protein Sequence MDSVAFEDVDVNFTQEEWALLDPSQKNLYRDVMWETMRNLASIGKKWKDQNIKDHYKHRGRNLRSHMLERLYQTKDGSQRGGIFSQFANQNLSKKIPGVKLCESIVYGEVSMGQSSLNRHIKDHSGHEPKEYQEYGEKPDTRNQCWKPFSSHHSFRTHEIIHTGEKLYDCKECGKTFFSLKRIRRHIITHSGYTPYKCKVCGKAFDYPSRFRTHERSHTGEKPYECQECGKAFTCITSVRRHMIKHTGDGPYKCKVCGKPFHSLSSFQVHERIHTGEKPFKCKQCGKAFSCSPTLRIHERTHTGEKPYECKQCGKAFSYLPSLRLHERIHTGEKPFVCKQCGKAFRSASTFQIHERTHTGEKPYECKECGEAFSCIPSMRRHMIKHTGEGPYKCKVCGKPFHSLSPFRIHERTHTGEKPYVCKHCGKAFVSSTSIRIHERTHTGEKPYECKQCGKAFSYLNSFRTHEMIHTGEKPFECKRCGKAFRSSSSFRLHERTHTGQKPYHCKECGKAYSCRASFQRHMLTHAEDGPPYKCMWESL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
45AcetylationRNLASIGKKWKDQNI
HHHHHHHHHHHCCCH		54.517825129
46AcetylationNLASIGKKWKDQNIK
HHHHHHHHHHCCCHH		55.027825137
80MethylationQTKDGSQRGGIFSQF
CCCCCCCCCCHHHHH		47.18115385879
94UbiquitinationFANQNLSKKIPGVKL
HHCCCHHCCCCCCEE		58.87-
138UbiquitinationEYQEYGEKPDTRNQC
HHHHCCCCCCCCCCC		43.78-
163PhosphorylationRTHEIIHTGEKLYDC
CCEEEEECCCCEEEH		36.3127251275
189PhosphorylationRIRRHIITHSGYTPY
HHHHHHHHCCCCCCC		14.9126074081
191PhosphorylationRRHIITHSGYTPYKC
HHHHHHCCCCCCCCC		25.5026074081
193PhosphorylationHIITHSGYTPYKCKV
HHHHCCCCCCCCCCC		13.9326074081
194PhosphorylationIITHSGYTPYKCKVC
HHHCCCCCCCCCCCC		24.5426074081
196PhosphorylationTHSGYTPYKCKVCGK
HCCCCCCCCCCCCCC		22.6326074081
238PhosphorylationKAFTCITSVRRHMIK
CEEEHHHHHHHHHHH		8.1728555341
247PhosphorylationRRHMIKHTGDGPYKC
HHHHHHHCCCCCCEE		31.78-
275PhosphorylationQVHERIHTGEKPFKC
ECCCCCCCCCCCEEC		44.6718669648
290PhosphorylationKQCGKAFSCSPTLRI
CCCCCEEECCCCEEE		20.6723312004
292PhosphorylationCGKAFSCSPTLRIHE
CCCEEECCCCEEEEC		21.5224247654
294PhosphorylationKAFSCSPTLRIHERT
CEEECCCCEEEECCC		16.6323312004
301PhosphorylationTLRIHERTHTGEKPY
CEEEECCCCCCCCCE		22.3229396449
303PhosphorylationRIHERTHTGEKPYEC
EEECCCCCCCCCEEC		46.5629496963
306UbiquitinationERTHTGEKPYECKQC
CCCCCCCCCEECCCC		55.00-
311SumoylationGEKPYECKQCGKAFS
CCCCEECCCCCCHHH		36.36-
311SumoylationGEKPYECKQCGKAFS
CCCCEECCCCCCHHH		36.36-
318PhosphorylationKQCGKAFSYLPSLRL
CCCCCHHHHCCCCCH		30.5321406692
319PhosphorylationQCGKAFSYLPSLRLH
CCCCHHHHCCCCCHH		19.0424114839
322PhosphorylationKAFSYLPSLRLHERI
CHHHHCCCCCHHHCC		24.4321406692
331PhosphorylationRLHERIHTGEKPFVC
CHHHCCCCCCCCEEE		44.67-
357PhosphorylationTFQIHERTHTGEKPY
EEEEECCCCCCCCCE		22.3229396449
359PhosphorylationQIHERTHTGEKPYEC
EEECCCCCCCCCEEC		46.5629496963
362UbiquitinationERTHTGEKPYECKEC
CCCCCCCCCEECCCH		55.00-
403PhosphorylationVCGKPFHSLSPFRIH
ECCCCCCCCCCEEEE		30.8129255136
405PhosphorylationGKPFHSLSPFRIHER
CCCCCCCCCEEEEEC		25.6329255136
413PhosphorylationPFRIHERTHTGEKPY
CEEEEECCCCCCCCE		22.32-
415PhosphorylationRIHERTHTGEKPYVC
EEEECCCCCCCCEEE		46.56-
418SumoylationERTHTGEKPYVCKHC
ECCCCCCCCEEECCC		42.89-
418SumoylationERTHTGEKPYVCKHC
ECCCCCCCCEEECCC		42.89-
441PhosphorylationSIRIHERTHTGEKPY
EEEEEECCCCCCCCE		22.3229396449
443PhosphorylationRIHERTHTGEKPYEC
EEEECCCCCCCCEEC		46.5629496963
446UbiquitinationERTHTGEKPYECKQC
ECCCCCCCCEECCCC		55.00-
451SumoylationGEKPYECKQCGKAFS
CCCCEECCCCHHHHH		36.36-
451SumoylationGEKPYECKQCGKAFS
CCCCEECCCCHHHHH		36.36-
471PhosphorylationRTHEMIHTGEKPFEC
CCCCCCCCCCCCCCC		35.7920068231
490PhosphorylationKAFRSSSSFRLHERT
CCHHCCCCEEEECCC		19.1424719451
533PhosphorylationHAEDGPPYKCMWESL
CCCCCCCCCCCEECC		21.69-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZN136_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZN136_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZN136_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MDFI_HUMANMDFIphysical
19060904
CEP70_HUMANCEP70physical
19060904
MTUS2_HUMANMTUS2physical
25416956
CCDB1_HUMANCCNDBP1physical
25416956
CEP70_HUMANCEP70physical
25416956
KR103_HUMANKRTAP10-3physical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZN136_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory