CRAC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRAC1_HUMAN
• UniProt AC: Q9NQ79
• Protein Name: Cartilage acidic protein 1
• Gene Name: CRTAC1
• Organism: Homo sapiens (Human).
• Sequence Length: 661
• Subcellular Localization: Secreted, extracellular space, extracellular matrix .
• Protein Sequence: MAPSADPGMSRMLPFLLLLWFLPITEGSQRAEPMFTAVTNSVLPPDYDSNPTQLNYGVAVTDVDHDGDFEIVVAGYNGPNLVLKYDRAQKRLVNIAVDERSSPYYALRDRQGNAIGVTACDIDGDGREEIYFLNTNNAFSGVATYTDKLFKFRNNRWEDILSDEVNVARGVASLFAGRSVACVDRKGSGRYSIYIANYAYGNVGPDALIEMDPEASDLSRGILALRDVAAEAGVSKYTGGRGVSVGPILSSSASDIFCDNENGPNFLFHNRGDGTFVDAAASAGVDDPHQHGRGVALADFNRDGKVDIVYGNWNGPHRLYLQMSTHGKVRFRDIASPKFSMPSPVRTVITADFDNDQELEIFFNNIAYRSSSANRLFRVIRREHGDPLIEELNPGDALEPEGRGTGGVVTDFDGDGMLDLILSHGESMAQPLSVFRGNQGFNNNWLRVVPRTRFGAFARGAKVVLYTKKSGAHLRIIDGGSGYLCEMEPVAHFGLGKDEASSVEVTWPDGKMVSRNVASGEMNSVLEILYPRDEDTLQDPAPLECGQGFSQQENGHCMDTNECIQFPFVCPRDKPVCVNTYGSYRCRTNKKCSRGYEPNEDGTACVGTLGQSPGPRPTTPTAAAATAAAAAAAGAATAAPVLVDGDLNLGSVVKESCEPSC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAPSADPGMSR ----CCCCCCCCHHH	35.45	19664995
310	Phosphorylation	DGKVDIVYGNWNGPH CCCEEEEEECCCCCE	12.69	-
343	Phosphorylation	SPKFSMPSPVRTVIT CCCCCCCCCCEEEEE	27.64	-
466	Phosphorylation	RGAKVVLYTKKSGAH CCCEEEEEECCCCCE	12.61	19835603
467	Phosphorylation	GAKVVLYTKKSGAHL CCEEEEEECCCCCEE	28.03	19835603
470	Phosphorylation	VVLYTKKSGAHLRII EEEEECCCCCEEEEE	42.65	-
502	Phosphorylation	LGKDEASSVEVTWPD CCCCCCCCEEEECCC	29.37	23403867
583 (in isoform 3)	Phosphorylation	-	10.05	18691976
608	O-linked_Glycosylation	DGTACVGTLGQSPGP CCCEEEEECCCCCCC	13.81	UniProtKB CARBOHYD
618	O-linked_Glycosylation	QSPGPRPTTPTAAAA CCCCCCCCCHHHHHH	46.84	UniProtKB CARBOHYD
619	O-linked_Glycosylation	SPGPRPTTPTAAAAT CCCCCCCCHHHHHHH	22.71	UniProtKB CARBOHYD
621	O-linked_Glycosylation	GPRPTTPTAAAATAA CCCCCCHHHHHHHHH	27.17	UniProtKB CARBOHYD
626	O-linked_Glycosylation	TPTAAAATAAAAAAA CHHHHHHHHHHHHHH	16.47	UniProtKB CARBOHYD
637	O-linked_Glycosylation	AAAAGAATAAPVLVD HHHHCCCCCCCEEEE	23.87	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CRAC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CRAC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRAC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MORN4_HUMAN	MORN4	physical	25416956
ZMYM6_HUMAN	ZMYM6	physical	28514442
MARE2_HUMAN	MAPRE2	physical	28514442
RUVB1_HUMAN	RUVBL1	physical	28514442
MTO1_HUMAN	MTO1	physical	28514442
TPC10_HUMAN	TRAPPC10	physical	28514442
FANCJ_HUMAN	BRIP1	physical	28514442
TPPC9_HUMAN	TRAPPC9	physical	28514442
MOCOS_HUMAN	MOCOS	physical	28514442
ASPM_HUMAN	ASPM	physical	28514442
KLDC3_HUMAN	KLHDC3	physical	28514442
VP13A_HUMAN	VPS13A	physical	28514442
RUVB2_HUMAN	RUVBL2	physical	28514442
NOCT_HUMAN	CCRN4L	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.