| UniProt ID | AGRL1_HUMAN | |
|---|---|---|
| UniProt AC | O94910 | |
| Protein Name | Adhesion G protein-coupled receptor L1 {ECO:0000312|HGNC:HGNC:20973} | |
| Gene Name | ADGRL1 {ECO:0000312|HGNC:HGNC:20973} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1474 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. Cell projection, axon . Cell projection, growth cone . Cell junction, synapse . Cell junction, synapse, presynaptic cell membrane . Cell junction, synapse, synaptosome . Colocalizes with TENM2 on the cell s |
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| Protein Description | Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity).. | |
| Protein Sequence | MARLAAVLWNLCVTAVLVTSATQGLSRAGLPFGLMRRELACEGYPIELRCPGSDVIMVENANYGRTDDKICDADPFQMENVQCYLPDAFKIMSQRCNNRTQCVVVAGSDAFPDPCPGTYKYLEVQYDCVPYKVEQKVFVCPGTLQKVLEPTSTHESEHQSGAWCKDPLQAGDRIYVMPWIPYRTDTLTEYASWEDYVAARHTTTYRLPNRVDGTGFVVYDGAVFYNKERTRNIVKYDLRTRIKSGETVINTANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEGNNGRLVVSQLNPYTLRFEGTWETGYDKRSASNAFMVCGVLYVLRSVYVDDDSEAAGNRVDYAFNTNANREEPVSLTFPNPYQFISSVDYNPRDNQLYVWNNYFVVRYSLEFGPPDPSAGPATSPPLSTTTTARPTPLTSTASPAATTPLRRAPLTTHPVGAINQLGPDLPPATAPVPSTRRPPAPNLHVSPELFCEPREVRRVQWPATQQGMLVERPCPKGTRGIASFQCLPALGLWNPRGPDLSNCTSPWVNQVAQKIKSGENAANIASELARHTRGSIYAGDVSSSVKLMEQLLDILDAQLQALRPIERESAGKNYNKMHKRERTCKDYIKAVVETVDNLLRPEALESWKDMNATEQVHTATMLLDVLEEGAFLLADNVREPARFLAAKENVVLEVTVLNTEGQVQELVFPQEEYPRKNSIQLSAKTIKQNSRNGVVKVVFILYNNLGLFLSTENATVKLAGEAGPGGPGGASLVVNSQVIAASINKESSRVFLMDPVIFTVAHLEDKNHFNANCSFWNYSERSMLGYWSTQGCRLVESNKTHTTCACSHLTNFAVLMAHREIYQGRINELLLSVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFLAELLFLVGIDKTQYEIACPIFAGLLHYFFLAAFSWLCLEGVHLYLLLVEVFESEYSRTKYYYLGGYCFPALVVGIAAAIDYRSYGTEKACWLRVDNYFIWSFIGPVSFVIVVNLVFLMVTLHKMIRSSSVLKPDSSRLDNIKSWALGAIALLFLLGLTWAFGLLFINKESVVMAYLFTTFNAFQGVFIFVFHCALQKKVHKEYSKCLRHSYCCIRSPPGGTHGSLKTSAMRSNTRYYTGTQSRIRRMWNDTVRKQTESSFMAGDINSTPTLNRGTMGNHLLTNPVLQPRGGTSPYNTLIAESVGFNPSSPPVFNSPGSYREPKHPLGGREACGMDTLPLNGNFNNSYSLRSGDFPPGDGGPEPPRGRNLADAAAFEKMIISELVHNNLRGSSSAAKGPPPPEPPVPPVPGGGGEEEAGGPGGADRAEIELLYKALEEPLLLPRAQSVLYQSDLDESESCTAEDGATSRPLSSPPGRDSLYASGANLRDSPSYPDSSPEGPSEALPPPPPAPPGPPEIYYTSRPPALVARNPLQGYYQVRRPSHEGYLAAPGLEGPGPDGDGQMQLVTSL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 93 | Phosphorylation | PDAFKIMSQRCNNRT CCHHHHHHHHCCCCC | - | ||
| 98 | N-linked_Glycosylation | IMSQRCNNRTQCVVV HHHHHCCCCCEEEEE | UniProtKB CARBOHYD | ||
| 121 | Phosphorylation | PCPGTYKYLEVQYDC CCCCCCEEEEEEEEE | - | ||
| 126 | Phosphorylation | YKYLEVQYDCVPYKV CEEEEEEEEEEEEEE | - | ||
| 131 | Phosphorylation | VQYDCVPYKVEQKVF EEEEEEEEEEEEEEE | - | ||
| 236 | Phosphorylation | RTRNIVKYDLRTRIK HHCCEEEEEECHHHC | - | ||
| 299 | Phosphorylation | VSQLNPYTLRFEGTW EEECCCCEEEEEEEE | 24719451 | ||
| 326 | Phosphorylation | FMVCGVLYVLRSVYV HHHHHHHHHEEEEEE | - | ||
| 330 | Phosphorylation | GVLYVLRSVYVDDDS HHHHHEEEEEECCCC | 24719451 | ||
| 431 | Phosphorylation | STASPAATTPLRRAP CCCCCCCCCCCCCCC | 20860994 | ||
| 432 | Phosphorylation | TASPAATTPLRRAPL CCCCCCCCCCCCCCC | 20860994 | ||
| 464 | O-linked_Glycosylation | ATAPVPSTRRPPAPN CCCCCCCCCCCCCCC | OGP | ||
| 531 | N-linked_Glycosylation | PRGPDLSNCTSPWVN CCCCCHHCCCCHHHH | UniProtKB CARBOHYD | ||
| 616 | Phosphorylation | RERTCKDYIKAVVET HHHHHHHHHHHHHHH | - | ||
| 640 | N-linked_Glycosylation | LESWKDMNATEQVHT HHHHHCCCHHHHHHH | UniProtKB CARBOHYD | ||
| 739 | Phosphorylation | NNLGLFLSTENATVK CCCCCEEECCCCEEE | 29978859 | ||
| 740 | Phosphorylation | NLGLFLSTENATVKL CCCCEEECCCCEEEE | 29978859 | ||
| 742 | N-linked_Glycosylation | GLFLSTENATVKLAG CCEEECCCCEEEECC | UniProtKB CARBOHYD | ||
| 744 | Phosphorylation | FLSTENATVKLAGEA EEECCCCEEEECCCC | 29978859 | ||
| 801 | N-linked_Glycosylation | DKNHFNANCSFWNYS CCCCCCCCCCCCCCC | UniProtKB CARBOHYD | ||
| 806 | N-linked_Glycosylation | NANCSFWNYSERSML CCCCCCCCCCCCCHH | UniProtKB CARBOHYD | ||
| 827 | N-linked_Glycosylation | GCRLVESNKTHTTCA CEEEEECCCCCCCHH | UniProtKB CARBOHYD | ||
| 959 | Ubiquitination | LVEVFESEYSRTKYY HHHHHHHCCCCCCEE | 27667366 | ||
| 964 | Ubiquitination | ESEYSRTKYYYLGGY HHCCCCCCEEEECCC | 27667366 | ||
| 966 | Phosphorylation | EYSRTKYYYLGGYCF CCCCCCEEEECCCCH | - | ||
| 967 | Phosphorylation | YSRTKYYYLGGYCFP CCCCCEEEECCCCHH | - | ||
| 989 | Phosphorylation | AAIDYRSYGTEKACW HHCCHHHCCCCCEEE | - | ||
| 1032 | Phosphorylation | TLHKMIRSSSVLKPD HHHHHHHCCCCCCCC | 20068231 | ||
| 1032 | Ubiquitination | TLHKMIRSSSVLKPD HHHHHHHCCCCCCCC | 29901268 | ||
| 1033 | Phosphorylation | LHKMIRSSSVLKPDS HHHHHHCCCCCCCCC | 20068231 | ||
| 1034 | Phosphorylation | HKMIRSSSVLKPDSS HHHHHCCCCCCCCCH | 20068231 | ||
| 1037 | Ubiquitination | IRSSSVLKPDSSRLD HHCCCCCCCCCHHHH | 29901268 | ||
| 1038 | Ubiquitination | RSSSVLKPDSSRLDN HCCCCCCCCCHHHHH | 27667366 | ||
| 1039 | Ubiquitination | SSSVLKPDSSRLDNI CCCCCCCCCHHHHHH | 27667366 | ||
| 1040 | Phosphorylation | SSVLKPDSSRLDNIK CCCCCCCCHHHHHHH | 20068231 | ||
| 1041 | Phosphorylation | SVLKPDSSRLDNIKS CCCCCCCHHHHHHHH | 20068231 | ||
| 1044 | Ubiquitination | KPDSSRLDNIKSWAL CCCCHHHHHHHHHHH | 27667366 | ||
| 1045 | Ubiquitination | PDSSRLDNIKSWALG CCCHHHHHHHHHHHH | 27667366 | ||
| 1081 | Ubiquitination | ESVVMAYLFTTFNAF HHHHHHHHHHHCHHH | 22817900 | ||
| 1086 | Ubiquitination | AYLFTTFNAFQGVFI HHHHHHCHHHCHHHH | 22817900 | ||
| 1116 | Phosphorylation | SKCLRHSYCCIRSPP HHHHCCCEEEEECCC | 25884760 | ||
| 1121 | Phosphorylation | HSYCCIRSPPGGTHG CCEEEEECCCCCCCC | - | ||
| 1126 | Phosphorylation | IRSPPGGTHGSLKTS EECCCCCCCCCCCHH | 27732954 | ||
| 1129 | Phosphorylation | PPGGTHGSLKTSAMR CCCCCCCCCCHHHCC | 28985074 | ||
| 1137 | Phosphorylation | LKTSAMRSNTRYYTG CCHHHCCCCCCEECC | 24719451 | ||
| 1141 | Phosphorylation | AMRSNTRYYTGTQSR HCCCCCCEECCCHHH | 28796482 | ||
| 1142 | Phosphorylation | MRSNTRYYTGTQSRI CCCCCCEECCCHHHH | 25884760 | ||
| 1143 | Phosphorylation | RSNTRYYTGTQSRIR CCCCCEECCCHHHHH | 28796482 | ||
| 1147 | Phosphorylation | RYYTGTQSRIRRMWN CEECCCHHHHHHHHH | 24719451 | ||
| 1154 | Ubiquitination | SRIRRMWNDTVRKQT HHHHHHHHHHHHHHC | 22817900 | ||
| 1154 (in isoform 2) | Ubiquitination | - | 21906983 | ||
| 1156 | Phosphorylation | IRRMWNDTVRKQTES HHHHHHHHHHHHCCC | - | ||
| 1159 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 1159 | Ubiquitination | MWNDTVRKQTESSFM HHHHHHHHHCCCCCC | 22817900 | ||
| 1160 | Ubiquitination | WNDTVRKQTESSFMA HHHHHHHHCCCCCCC | 22817900 | ||
| 1161 | Ubiquitination | NDTVRKQTESSFMAG HHHHHHHCCCCCCCC | 22817900 | ||
| 1164 | Phosphorylation | VRKQTESSFMAGDIN HHHHCCCCCCCCCCC | - | ||
| 1166 | Ubiquitination | KQTESSFMAGDINST HHCCCCCCCCCCCCC | 22817900 | ||
| 1167 | Ubiquitination | QTESSFMAGDINSTP HCCCCCCCCCCCCCC | 22817900 | ||
| 1172 | Phosphorylation | FMAGDINSTPTLNRG CCCCCCCCCCCCCCC | 24719451 | ||
| 1173 | Phosphorylation | MAGDINSTPTLNRGT CCCCCCCCCCCCCCC | 27050516 | ||
| 1175 | Phosphorylation | GDINSTPTLNRGTMG CCCCCCCCCCCCCCC | 27732954 | ||
| 1194 | Methylation | TNPVLQPRGGTSPYN CCCCCCCCCCCCCCC | - | ||
| 1197 | Phosphorylation | VLQPRGGTSPYNTLI CCCCCCCCCCCCCEE | 27732954 | ||
| 1198 | Phosphorylation | LQPRGGTSPYNTLIA CCCCCCCCCCCCEEE | 27732954 | ||
| 1200 | Phosphorylation | PRGGTSPYNTLIAES CCCCCCCCCCEEECC | 24719451 | ||
| 1202 | Phosphorylation | GGTSPYNTLIAESVG CCCCCCCCEEECCCC | 27732954 | ||
| 1207 | Phosphorylation | YNTLIAESVGFNPSS CCCEEECCCCCCCCC | 27732954 | ||
| 1220 | Phosphorylation | SSPPVFNSPGSYREP CCCCCCCCCCCCCCC | 28348404 | ||
| 1223 | Phosphorylation | PVFNSPGSYREPKHP CCCCCCCCCCCCCCC | 28348404 | ||
| 1252 | Phosphorylation | NGNFNNSYSLRSGDF CCCCCCCCCCCCCCC | 25884760 | ||
| 1253 | Phosphorylation | GNFNNSYSLRSGDFP CCCCCCCCCCCCCCC | 24719451 | ||
| 1337 | Phosphorylation | RAEIELLYKALEEPL HHHHHHHHHHHHCCC | 25884760 | ||
| 1351 | Phosphorylation | LLLPRAQSVLYQSDL CCCHHHHHHHCCCCC | 30624053 | ||
| 1356 | Phosphorylation | AQSVLYQSDLDESES HHHHHCCCCCCCCCC | 28985074 | ||
| 1371 | Phosphorylation | CTAEDGATSRPLSSP CCCCCCCCCCCCCCC | 24076635 | ||
| 1376 | Phosphorylation | GATSRPLSSPPGRDS CCCCCCCCCCCCCCC | 24076635 | ||
| 1377 | Phosphorylation | ATSRPLSSPPGRDSL CCCCCCCCCCCCCCC | 24076635 | ||
| 1383 | Phosphorylation | SSPPGRDSLYASGAN CCCCCCCCCCCCCCC | 28796482 | ||
| 1385 | Phosphorylation | PPGRDSLYASGANLR CCCCCCCCCCCCCCC | 25884760 | ||
| 1387 | Phosphorylation | GRDSLYASGANLRDS CCCCCCCCCCCCCCC | 28796482 | ||
| 1440 | Phosphorylation | ARNPLQGYYQVRRPS ECCCCCCEEEECCCC | 21945579 | ||
| 1441 | Phosphorylation | RNPLQGYYQVRRPSH CCCCCCEEEECCCCC | 21945579 | ||
| 1446 | Phosphorylation | GYYQVRRPSHEGYLA CEEEECCCCCCCCCC | 32142685 | ||
| 1447 | Phosphorylation | YYQVRRPSHEGYLAA EEEECCCCCCCCCCC | 20068231 | ||
| 1451 | Phosphorylation | RRPSHEGYLAAPGLE CCCCCCCCCCCCCCC | 30576142 | ||
| 1472 | Phosphorylation | DGQMQLVTSL----- CCCCEEEECC----- | 27732954 | ||
| 1473 | Phosphorylation | GQMQLVTSL------ CCCEEEECC------ | 27732954 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AGRL1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AGRL1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AGRL1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of AGRL1_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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