MOAP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MOAP1_HUMAN
• UniProt AC: Q96BY2
• Protein Name: Modulator of apoptosis 1
• Gene Name: MOAP1
• Organism: Homo sapiens (Human).
• Sequence Length: 351
• Protein Description: Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation..
• Protein Sequence: MTLRLLEDWCRGMDMNPRKALLIAGISQSCSVAEIEEALQAGLAPLGEYRLLGRMFRRDENRKVALVGLTAETSHALVPKEIPGKGGIWRVIFKPPDPDNTFLSRLNEFLAGEGMTVGELSRALGHENGSLDPEQGMIPEMWAPMLAQALEALQPALQCLKYKKLRVFSGRESPEPGEEEFGRWMFHTTQMIKAWQVPDVEKRRRLLESLRGPALDVIRVLKINNPLITVDECLQALEEVFGVTDNPRELQVKYLTTYQKDEEKLSAYVLRLEPLLQKLVQRGAIERDAVNQARLDQVIAGAVHKTIRRELNLPEDGPAPGFLQLLVLIKDYEAAEEEEALLQAILEGNFT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	Ubiquitination	FRRDENRKVALVGLT EECCCCCCEEEEEEE	43.36	-
80	Ubiquitination	TSHALVPKEIPGKGG CCCCCCCCCCCCCCC	61.88	22817900
85	Ubiquitination	VPKEIPGKGGIWRVI CCCCCCCCCCEEEEE	48.92	22817900
94	Ubiquitination	GIWRVIFKPPDPDNT CEEEEEECCCCCCCC	44.51	21906983
122	Methylation	MTVGELSRALGHENG CCHHHHHHHHCCCCC	46.59	24381627
173	Phosphorylation	RVFSGRESPEPGEEE EEECCCCCCCCCCHH	32.95	30624053
193	Ubiquitination	FHTTQMIKAWQVPDV HCHHHHHHHHCCCCH	37.92	-
202	Ubiquitination	WQVPDVEKRRRLLES HCCCCHHHHHHHHHH	51.56	21906983
209	Phosphorylation	KRRRLLESLRGPALD HHHHHHHHCCCCHHH	24.28	28674151
253	Ubiquitination	NPRELQVKYLTTYQK CCCHHHEEEEECCCC	22.91	21890473
253	Ubiquitination	NPRELQVKYLTTYQK CCCHHHEEEEECCCC	22.91	21906983
254	Phosphorylation	PRELQVKYLTTYQKD CCHHHEEEEECCCCC	15.49	-
258	Phosphorylation	QVKYLTTYQKDEEKL HEEEEECCCCCHHHH	14.34	-
260	Ubiquitination	KYLTTYQKDEEKLSA EEEECCCCCHHHHHH	57.61	21906983
264	Ubiquitination	TYQKDEEKLSAYVLR CCCCCHHHHHHHHHH	45.77	22817900
278	Ubiquitination	RLEPLLQKLVQRGAI HHHHHHHHHHHCCCC	51.07	21890473
278	Ubiquitination	RLEPLLQKLVQRGAI HHHHHHHHHHHCCCC	51.07	21906983
305	Ubiquitination	VIAGAVHKTIRRELN HHHHHHHHHHHHHCC	38.76	21906983
305	Ubiquitination	VIAGAVHKTIRRELN HHHHHHHHHHHHHCC	38.76	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	FZR1	Q9UM11	PMID:22529100
-	K	Ubiquitination	E3 ubiquitin ligase	TRIM39	Q9HCM9	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MOAP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MOAP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DPPA2_HUMAN	DPPA2	physical	16189514
MOAP1_HUMAN	MOAP1	physical	11060313
BAX_HUMAN	BAX	physical	11060313
BCL2_HUMAN	BCL2	physical	11060313
B2CL1_HUMAN	BCL2L1	physical	11060313
TRI39_HUMAN	TRIM39	physical	19100260
FZR1_HUMAN	FZR1	physical	22529100
PNMA5_HUMAN	PNMA5	physical	25416956
UBR5_HUMAN	UBR5	physical	27721409
DDB1_HUMAN	DDB1	physical	27721409
DYRK2_HUMAN	DYRK2	physical	27721409
DCAF1_HUMAN	VPRBP	physical	27721409
PNMA1_HUMAN	PNMA1	physical	28514442
PNM8A_HUMAN	PNMAL1	physical	28514442
MYO5C_HUMAN	MYO5C	physical	28514442
SIR2_HUMAN	SIRT2	physical	28514442
PNMA2_HUMAN	PNMA2	physical	28514442
ASPM_HUMAN	ASPM	physical	28514442
MYO9B_HUMAN	MYO9B	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.