MEGF8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MEGF8_HUMAN
• UniProt AC: Q7Z7M0
• Protein Name: Multiple epidermal growth factor-like domains protein 8
• Gene Name: MEGF8
• Organism: Homo sapiens (Human).
• Sequence Length: 2845
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: Acts as a negative regulator of hedgehog signaling..
• Protein Sequence: MALGKVLAMALVLALAVLGSLSPGARAGDCKGQRQVLREAPGFVTDGAGNYSVNGNCEWLIEAPSPQHRILLDFLFLDTECTYDYLFVYDGDSPRGPLLASLSGSTRPPPIEASSGKMLLHLFSDANYNLLGFNASFRFSLCPGGCQSHGQCQPPGVCACEPGWGGPDCGLQECSAYCGSHGTCASPLGPCRCEPGFLGRACDLHLWENQGAGWWHNVSARDPAFSARIGAAGAFLSPPGLLAVFGGQDLNNALGDLVLYNFSANTWESWDLSPAPAARHSHVAVAWAGSLVLMGGELADGSLTNDVWAFSPLGRGHWELLAPPASSSSGPPGLAGHAAALVDDVWLYVSGGRTPHDLFSSGLFRFRLDSTSGGYWEQVIPAGGRPPAATGHSMVFHAPSRALLVHGGHRPSTARFSVRVNSTELFHVDRHVWTTLKGRDGLQGPRERAFHTASVLGNYMVVYGGNVHTHYQEEKCYEDGIFFYHLGCHQWVSGAELAPPGTPEGRAAPPSGRYSHVAAVLGGSVLLVAGGYSGRPRGDLMAYKVPPFVFQAPAPDYHLDYCSMYTDHSVCSRDPECSWCQGACQAAPPPGTPLGACPAASCLGLGRLLGDCQACLAFSSPTAPPRGPGTLGWCVHNESCLPRPEQARCRGEQISGTVGWWGPAPVFVTSLEACVTQSFLPGLHLLTFQQPPNTSQPDKVSIVRSTTITLTPSAETDVSLVYRGFIYPMLPGGPGGPGAEDVAVWTRAQRLHVLARMARGPDTENMEEVGRWVAHQEKETRRLQRPGSARLFPLPGRDHKYAVEIQGQLNGSAGPGHSELTLLWDRTGVPGGSEISFFFLEPYRSSSCTSYSSCLGCLADQGCGWCLTSATCHLRQGGAHCGDDGAGGSLLVLVPTLCPLCEEHRDCHACTQDPFCEWHQSTSRKGDAACSRRGRGRGALKSPEECPPLCSQRLTCEDCLANSSQCAWCQSTHTCFLFAAYLARYPHGGCRGWDDSVHSEPRCRSCDGFLTCHECLQSHECGWCGNEDNPTLGRCLQGDFSGPLGGGNCSLWVGEGLGLPVALPARWAYARCPDVDECRLGLARCHPRATCLNTPLSYECHCQRGYQGDGISHCNRTCLEDCGHGVCSGPPDFTCVCDLGWTSDLPPPTPAPGPPAPRCSRDCGCSFHSHCRKRGPGFCDECQDWTWGEHCERCRPGSFGNATGSRGCRPCQCNGHGDPRRGHCDNLSGLCFCQDHTEGAHCQLCSPGYYGDPRAGGSCFRECGGRALLTNVSSVALGSRRVGGLLPPGGGAARAGPGLSYCVWVVSATEELQPCAPGTLCPPLTLTFSPDSSTPCTLSYVLAFDGFPRFLDTGVVQSDRSLIAAFCGQRRDRPLTVQALSGLLVLHWEANGSSSWGFNASVGSARCGSGGPGSCPVPQECVPQDGAAGAGLCRCPQGWAGPHCRMALCPENCNAHTGAGTCNQSLGVCICAEGFGGPDCATKLDGGQLVWETLMDSRLSADTASRFLHRLGHTMVDGPDATLWMFGGLGLPQGLLGNLYRYSVSERRWTQMLAGAEDGGPGPSPRSFHAAAYVPAGRGAMYLLGGLTAGGVTRDFWVLNLTTLQWRQEKAPQTVELPAVAGHTLTARRGLSLLLVGGYSPENGFNQQLLEYQLATGTWVSGAQSGTPPTGLYGHSAVYHEATDSLYVFGGFRFHVELAAPSPELYSLHCPDRTWSLLAPSQGAKRDRMRNVRGSSRGLGQVPGEQPGSWGFREVRKKMALWAALAGTGGFLEEISPHLKEPRPRLFHASALLGDTMVVLGGRSDPDEFSSDVLLYQVNCNAWLLPDLTRSASVGPPMEESVAHAVAAVGSRLYISGGFGGVALGRLLALTLPPDPCRLLSSPEACNQSGACTWCHGACLSGDQAHRLGCGGSPCSPMPRSPEECRRLRTCSECLARHPRTLQPGDGEASTPRCKWCTNCPEGACIGRNGSCTSENDCRINQREVFWAGNCSEAACGAADCEQCTREGKCMWTRQFKRTGETRRILSVQPTYDWTCFSHSLLNVSPMPVESSPPLPCPTPCHLLPNCTSCLDSKGADGGWQHCVWSSSLQQCLSPSYLPLRCMAGGCGRLLRGPESCSLGCAQATQCALCLRRPHCGWCAWGGQDGGGRCMEGGLSGPRDGLTCGRPGASWAFLSCPPEDECANGHHDCNETQNCHDQPHGYECSCKTGYTMDNMTGLCRPVCAQGCVNGSCVEPDHCRCHFGFVGRNCSTECRCNRHSECAGVGARDHCLLCRNHTKGSHCEQCLPLFVGSAVGGGTCRPCHAFCRGNSHICISRKELQMSKGEPKKYSLDPEEIENWVTEGPSEDEAVCVNCQNNSYGEKCESCLQGYFLLDGKCTKCQCNGHADTCNEQDGTGCPCQNNTETGTCQGSSPSDRRDCYKYQCAKCRESFHGSPLGGQQCYRLISVEQECCLDPTSQTNCFHEPKRRALGPGRTVLFGVQPKFTNVDIRLTLDVTFGAVDLYVSTSYDTFVVRVAPDTGVHTVHIQPPPAPPPPPPPADGGPRGAGDPGGAGASSGPGAPAEPRVREVWPRGLITYVTVTEPSAVLVVRGVRDRLVITYPHEHHALKSSRFYLLLLGVGDPSGPGANGSADSQGLLFFRQDQAHIDLFVFFSVFFSCFFLFLSLCVLLWKAKQALDQRQEQRRHLQEMTKMASRPFAKVTVCFPPDPTAPASAWKPAGLPPPAFRRSEPFLAPLLLTGAGGPWGPMGGGCCPPAIPATTAGLRAGPITLEPTEDGMAGVATLLLQLPGGPHAPNGACLGSALVTLRHRLHEYCGGGGGAGGSGHGTGAGRKGLLSQDNLTSMSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	LALAVLGSLSPGARA HHHHHHHCCCCCCCC	22.85	-
50	N-linked_Glycosylation	FVTDGAGNYSVNGNC CEECCCCCCEECCCE	25.93	UniProtKB CARBOHYD
85	Phosphorylation	DTECTYDYLFVYDGD CCCCCCEEEEEECCC	7.51	-
140	Phosphorylation	FNASFRFSLCPGGCQ CCEEEEEEECCCCCC	25.46	24719451
217	N-linked_Glycosylation	QGAGWWHNVSARDPA CCCCCCCCCCCCCCC	18.73	UniProtKB CARBOHYD
302	Phosphorylation	GGELADGSLTNDVWA CCEECCCCCCCCEEE	32.35	22210691
304	Phosphorylation	ELADGSLTNDVWAFS EECCCCCCCCEEEEC	30.94	22210691
311	Phosphorylation	TNDVWAFSPLGRGHW CCCEEEECCCCCCCC	16.09	22210691
511	Phosphorylation	EGRAAPPSGRYSHVA CCCCCCCCCCCCHHH	34.54	24300666
619	Phosphorylation	CQACLAFSSPTAPPR CCHHHHHCCCCCCCC	29.78	28122231
620	Phosphorylation	QACLAFSSPTAPPRG CHHHHHCCCCCCCCC	21.59	28122231
746	Phosphorylation	AEDVAVWTRAQRLHV HHHHHHHHHHHHHHH	14.99	24400094
942	Phosphorylation	RGRGALKSPEECPPL CCCCCCCCHHHCCCC	38.09	27732954
951	Phosphorylation	EECPPLCSQRLTCED HHCCCCCCCCCCHHH	26.47	27732954
1048	N-linked_Glycosylation	SGPLGGGNCSLWVGE CCCCCCCCCEEEEEC	18.58	UniProtKB CARBOHYD
1149	O-linked_Glycosylation	TSDLPPPTPAPGPPA CCCCCCCCCCCCCCC	37.54	OGP
1169	Phosphorylation	DCGCSFHSHCRKRGP CCCCCCCHHHHHHCC	23.44	-
1198	Phosphorylation	CERCRPGSFGNATGS CCCCCCCCCCCCCCC	32.44	22210691
1203	Phosphorylation	PGSFGNATGSRGCRP CCCCCCCCCCCCCCC	39.42	22210691
1250	Phosphorylation	QLCSPGYYGDPRAGG CCCCCCCCCCCCCCC	22.44	-
1258	Phosphorylation	GDPRAGGSCFRECGG CCCCCCCCCHHHCCC	14.79	-
1271	N-linked_Glycosylation	GGRALLTNVSSVALG CCEEEEECCCCHHCC	31.48	16335952
1353	Phosphorylation	GFPRFLDTGVVQSDR CCCCHHCCCCCCCCH	33.74	-
1542	Phosphorylation	LLGNLYRYSVSERRW HHHHHHHEECCHHHH	10.40	28102081
1543	Phosphorylation	LGNLYRYSVSERRWT HHHHHHEECCHHHHH	15.35	23401153
1545	Phosphorylation	NLYRYSVSERRWTQM HHHHEECCHHHHHHH	21.31	30576142
1573	Phosphorylation	RSFHAAAYVPAGRGA HHCCEEEEECCCCCH	11.40	22210691
1582	Phosphorylation	PAGRGAMYLLGGLTA CCCCCHHHHCCCCCC	9.76	22210691
1588	Phosphorylation	MYLLGGLTAGGVTRD HHHCCCCCCCCCCCC	26.91	24043423
1593	Phosphorylation	GLTAGGVTRDFWVLN CCCCCCCCCCEEEEE	28.00	24043423
1602	Phosphorylation	DFWVLNLTTLQWRQE CEEEEEEECCCHHHH	25.12	22210691
1749	Phosphorylation	VPGEQPGSWGFREVR CCCCCCCCCCHHHHH	30.61	-
1790	Phosphorylation	RPRLFHASALLGDTM CCCCCHHHHHHCCEE	15.75	-
1796	Phosphorylation	ASALLGDTMVVLGGR HHHHHCCEEEEECCC	15.29	-
1951	Phosphorylation	PGDGEASTPRCKWCT CCCCCCCCCCCCCCC	23.07	-
2023	Methylation	FKRTGETRRILSVQP CCCCCCCEEEEEECC	21.24	24388057
2066	N-linked_Glycosylation	TPCHLLPNCTSCLDS CCCCCCCCCCCCCCC	41.49	UniProtKB CARBOHYD
2229	N-linked_Glycosylation	VCAQGCVNGSCVEPD HHCCCCCCCCCCCCC	40.51	UniProtKB CARBOHYD
2280	Phosphorylation	CRNHTKGSHCEQCLP CCCCCCCCCHHHHHH	26.90	-
2485	Phosphorylation	FGVQPKFTNVDIRLT EECCCCCCCCEEEEE	40.22	26503514

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MEGF8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MEGF8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MEGF8_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MEGF8_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614976: Carpenter syndrome 2 (CRPT2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry.";
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.;
J. Proteome Res. 4:2070-2080(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1271, AND MASSSPECTROMETRY.
PubMed: 16335952