PMM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PMM1_HUMAN
• UniProt AC: Q92871
• Protein Name: Phosphomannomutase 1
• Gene Name: PMM1
• Organism: Homo sapiens (Human).
• Sequence Length: 262
• Subcellular Localization: Cytoplasm.
• Protein Description: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain..
• Protein Sequence: MAVTAQAARRKERVLCLFDVDGTLTPARQKIDPEVAAFLQKLRSRVQIGVVGGSDYCKIAEQLGDGDEVIEKFDYVFAENGTVQYKHGRLLSKQTIQNHLGEELLQDLINFCLSYMALLRLPKKRGTFIEFRNGMLNISPIGRSCTLEERIEFSELDKKEKIREKFVEALKTEFAGKGLRFSRGGMISFDVFPEGWDKRYCLDSLDQDSFDTIHFFGNETSPGGNDFEIFADPRTVGHSVVSPQDTVQRCREIFFPETAHEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAVTAQAAR ------CCHHHHHHH	13.84	22814378
19	Phosphorylation	ERVLCLFDVDGTLTP CCEEEEEECCCCCCC	25.34	9603909
30	Ubiquitination	TLTPARQKIDPEVAA CCCCHHHHCCHHHHH	43.45	21890473
30	Ubiquitination	TLTPARQKIDPEVAA CCCCHHHHCCHHHHH	43.45	21890473
41	Ubiquitination	EVAAFLQKLRSRVQI HHHHHHHHHHHCCEE	48.27	21890473
41	Ubiquitination	EVAAFLQKLRSRVQI HHHHHHHHHHHCCEE	48.27	21890473
58	Ubiquitination	VGGSDYCKIAEQLGD CCCCHHHHHHHHHCC	38.43	-
114	Phosphorylation	DLINFCLSYMALLRL HHHHHHHHHHHHHCC	17.65	22210691
115	Phosphorylation	LINFCLSYMALLRLP HHHHHHHHHHHHCCC	3.57	22210691
158	Ubiquitination	IEFSELDKKEKIREK CCHHHHCHHHHHHHH	75.38	-
165	Ubiquitination	KKEKIREKFVEALKT HHHHHHHHHHHHHHH	44.88	-
171	Ubiquitination	EKFVEALKTEFAGKG HHHHHHHHHHHCCCC	53.72	-
177	Ubiquitination	LKTEFAGKGLRFSRG HHHHHCCCCCCCCCC	51.87	-
183	Methylation	GKGLRFSRGGMISFD CCCCCCCCCCCEEEE	42.86	115487977
198	Ubiquitination	VFPEGWDKRYCLDSL CCCCCCCCCEEHHHC	38.46	-
235	Phosphorylation	EIFADPRTVGHSVVS EEEECCCCCCCCCCC	35.91	23312004
239	Phosphorylation	DPRTVGHSVVSPQDT CCCCCCCCCCCHHHH	20.48	23312004
242	Phosphorylation	TVGHSVVSPQDTVQR CCCCCCCCHHHHHHH	18.06	23312004
246	Phosphorylation	SVVSPQDTVQRCREI CCCCHHHHHHHHHHH	17.19	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PMM1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PMM1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PMM1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAB6A_HUMAN	RAB6A	physical	16189514
ZN363_HUMAN	RCHY1	physical	21988832
RAB6A_HUMAN	RAB6A	physical	25416956
POTEE_HUMAN	POTEE	physical	26186194
HPHL1_HUMAN	HEPHL1	physical	26186194
PMM2_HUMAN	PMM2	physical	26186194
QRIC1_HUMAN	QRICH1	physical	26186194
DSG4_HUMAN	DSG4	physical	26186194
GBB2_HUMAN	GNB2	physical	26186194
DUS14_HUMAN	DUSP14	physical	26186194
LRC15_HUMAN	LRRC15	physical	26186194
PMM2_HUMAN	PMM2	physical	28514442
POTEE_HUMAN	POTEE	physical	28514442
QRIC1_HUMAN	QRICH1	physical	28514442
DSG4_HUMAN	DSG4	physical	28514442
HPHL1_HUMAN	HEPHL1	physical	28514442
DUS14_HUMAN	DUSP14	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.