PMM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PMM2_HUMAN
• UniProt AC: O15305
• Protein Name: Phosphomannomutase 2
• Gene Name: PMM2
• Organism: Homo sapiens (Human).
• Sequence Length: 246
• Subcellular Localization: Cytoplasm.
• Protein Description: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions..
• Protein Sequence: MAAPGPALCLFDVDGTLTAPRQKITKEMDDFLQKLRQKIKIGVVGGSDFEKVQEQLGNDVVEKYDYVFPENGLVAYKDGKLLCRQNIQSHLGEALIQDLINYCLSYIAKIKLPKKRGTFIEFRNGMLNVSPIGRSCSQEERIEFYELDKKENIRQKFVADLRKEFAGKGLTFSIGGQISFDVFPDGWDKRYCLRHVENDGYKTIYFFGDKTMPGGNDHEIFTDPRTMGYSVTAPEDTRRICELLFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAPGPALC ------CCCCCCEEE	23.51	22223895
16	Phosphorylation	CLFDVDGTLTAPRQK EEEEECCCCCCCHHH	19.24	30243723
18	Phosphorylation	FDVDGTLTAPRQKIT EEECCCCCCCHHHHH	34.16	20068231
26	Ubiquitination	APRQKITKEMDDFLQ CCHHHHHHHHHHHHH	55.29	-
34	Acetylation	EMDDFLQKLRQKIKI HHHHHHHHHHHHHCE	48.02	26822725
34	Ubiquitination	EMDDFLQKLRQKIKI HHHHHHHHHHHHHCE	48.02	-
34	Ubiquitination	EMDDFLQKLRQKIKI HHHHHHHHHHHHHCE	48.02	-
47	Phosphorylation	KIGVVGGSDFEKVQE CEEEECCCCHHHHHH	32.95	24275569
51	Ubiquitination	VGGSDFEKVQEQLGN ECCCCHHHHHHHHCC	49.57	21890473
51	Ubiquitination	VGGSDFEKVQEQLGN ECCCCHHHHHHHHCC	49.57	-
63	Ubiquitination	LGNDVVEKYDYVFPE HCCCHHHHCCEECCC	31.63	-
76	Phosphorylation	PENGLVAYKDGKLLC CCCCEEEEECCEEEE	11.35	-
77	Ubiquitination	ENGLVAYKDGKLLCR CCCEEEEECCEEEEH	50.71	21890473
77	Ubiquitination	ENGLVAYKDGKLLCR CCCEEEEECCEEEEH	50.71	-
80	Acetylation	LVAYKDGKLLCRQNI EEEEECCEEEEHHHH	48.71	25953088
126	Sulfoxidation	FIEFRNGMLNVSPIG EEEEECCCEEECCCC	2.55	28183972
130	Phosphorylation	RNGMLNVSPIGRSCS ECCCEEECCCCCCCC	15.10	23911959
137	Phosphorylation	SPIGRSCSQEERIEF CCCCCCCCHHHCEEE	41.70	23911959
145	Phosphorylation	QEERIEFYELDKKEN HHHCEEEEECCHHHC	11.64	26356563
149	Acetylation	IEFYELDKKENIRQK EEEEECCHHHCHHHH	74.70	23954790
149	2-Hydroxyisobutyrylation	IEFYELDKKENIRQK EEEEECCHHHCHHHH	74.70	-
156	Ubiquitination	KKENIRQKFVADLRK HHHCHHHHHHHHHHH	31.77	-
202	Ubiquitination	HVENDGYKTIYFFGD EEECCCEEEEEEECC	33.69	21890473
202	Ubiquitination	HVENDGYKTIYFFGD EEECCCEEEEEEECC	33.69	21890473
203	Phosphorylation	VENDGYKTIYFFGDK EECCCEEEEEEECCC	16.66	28152594
205	Phosphorylation	NDGYKTIYFFGDKTM CCCEEEEEEECCCCC	9.70	28152594
210	2-Hydroxyisobutyrylation	TIYFFGDKTMPGGND EEEEECCCCCCCCCC	47.29	-
210	Acetylation	TIYFFGDKTMPGGND EEEEECCCCCCCCCC	47.29	25953088
227	Sulfoxidation	IFTDPRTMGYSVTAP CCCCCCCCCEECCCC	5.11	21406390
229	Phosphorylation	TDPRTMGYSVTAPED CCCCCCCEECCCCHH	6.80	20068231
230	Phosphorylation	DPRTMGYSVTAPEDT CCCCCCEECCCCHHH	13.78	20068231
232	Phosphorylation	RTMGYSVTAPEDTRR CCCCEECCCCHHHHH	30.47	20068231
237	Phosphorylation	SVTAPEDTRRICELL ECCCCHHHHHHHHHH	21.86	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PMM2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PMM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PMM2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAGL3_HUMAN	TAGLN3	physical	22939629
ACY3_HUMAN	ACY3	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 212065: Congenital disorder of glycosylation 1A (CDG1A)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.