| UniProt ID | ACY3_HUMAN | |
|---|---|---|
| UniProt AC | Q96HD9 | |
| Protein Name | N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) | |
| Gene Name | ACY3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 319 | |
| Subcellular Localization |
Apical cell membrane Peripheral membrane protein . Cytoplasm . Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm. |
|
| Protein Description | Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids (By similarity).. | |
| Protein Sequence | MCSLPVPREPLRRVAVTGGTHGNEMSGVYLARHWLHAPAELQRASFSAVPVLANPAATSGCRRYVDHDLNRTFTSSFLNSRPTPDDPYEVTRARELNQLLGPKASGQAFDFVLDLHNTTANMGTCLIAKSSHEVFAMHLCRHLQLQYPELSCQVFLYQRSGEESYNLDSVAKNGLGLELGPQPQGVLRADIFSRMRTLVATVLDFIELFNQGTAFPAFEMEAYRPVGVVDFPRTEAGHLAGTVHPQLQDRDFQPLQPGAPIFQMFSGEDLLYEGESTVYPVFINEAAYYEKGVAFVQTEKFTFTVPAMPALTPAPSPAS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 58 | Phosphorylation | VLANPAATSGCRRYV EECCHHHCCCHHHHC | 27.97 | 50563381 | |
| 88 | Phosphorylation | RPTPDDPYEVTRARE CCCCCCHHHHHHHHH | 29.99 | 21253578 | |
| 160 | Phosphorylation | QVFLYQRSGEESYNL EEEEEECCCCCCCCH | 34.72 | 28857561 | |
| 165 | Phosphorylation | QRSGEESYNLDSVAK ECCCCCCCCHHHHHH | 24.03 | 11906375 | |
| 312 | Phosphorylation | VPAMPALTPAPSPAS ECCCCCCCCCCCCCC | 21.36 | 28857561 | |
| 316 | Phosphorylation | PALTPAPSPAS---- CCCCCCCCCCC---- | 34.89 | 46158923 | |
| 319 | Phosphorylation | TPAPSPAS------- CCCCCCCC------- | 44.10 | 28857561 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ACY3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ACY3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ACY3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| M3K8_HUMAN | MAP3K8 | physical | 21988832 | |
| RARG_HUMAN | RARG | physical | 21988832 | |
| RRAS_HUMAN | RRAS | physical | 21988832 | |
| ACY3_HUMAN | ACY3 | physical | 25416956 | |
| KR108_HUMAN | KRTAP10-8 | physical | 25416956 | |
| KR103_HUMAN | KRTAP10-3 | physical | 25416956 | |
| NT2NL_HUMAN | NOTCH2NL | physical | 25416956 |
| Kegg Disease | |
|---|---|
| There are no disease associations of PTM sites. | |
| OMIM Disease | |
| There are no disease associations of PTM sites. | |
| Kegg Drug | |
| There are no disease associations of PTM sites. | |
| DrugBank | |
| DB00128 | L-Aspartic Acid |
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