| UniProt ID | PCSK6_HUMAN | |
|---|---|---|
| UniProt AC | P29122 | |
| Protein Name | Proprotein convertase subtilisin/kexin type 6 | |
| Gene Name | PCSK6 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 969 | |
| Subcellular Localization |
Isoform PACE4A-I: Secreted. Isoform PACE4A-II: Secreted. Isoform PACE4C: Endoplasmic reticulum. Not secreted, remains probably in zymogen form in endoplasmic reticulum. Isoform PACE4CS: Endoplasmic reticulum. Not secreted, remains probably in |
|
| Protein Description | Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues.. | |
| Protein Sequence | MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPPKAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTCLLAG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 136 | Ubiquitination | LRMDPQVKWLQQQEV EECCHHHHHHHHHHH | 36.62 | 2189047 | |
| 136 (in isoform 8) | Ubiquitination | - | 36.62 | 21890473 | |
| 136 (in isoform 6) | Ubiquitination | - | 36.62 | 21890473 | |
| 136 (in isoform 5) | Ubiquitination | - | 36.62 | 21890473 | |
| 136 (in isoform 4) | Ubiquitination | - | 36.62 | 21890473 | |
| 136 (in isoform 3) | Ubiquitination | - | 36.62 | 21890473 | |
| 136 (in isoform 2) | Ubiquitination | - | 36.62 | 21890473 | |
| 136 (in isoform 1) | Ubiquitination | - | 36.62 | 21890473 | |
| 136 (in isoform 7) | Ubiquitination | - | 36.62 | 21890473 | |
| 259 | N-linked_Glycosylation | GEVAASANNSYCIVG HHHHHHCCCCEEEEE | 35.17 | UniProtKB CARBOHYD | |
| 339 | Phosphorylation | KGRQGLGSIFVWASG CCCCCCCEEEEEECC | 20.21 | 23403867 | |
| 345 | Phosphorylation | GSIFVWASGNGGREG CEEEEEECCCCCCCC | 19.65 | 23403867 | |
| 637 | Phosphorylation | YGTAEHPYHTFSAHQ EECCCCCCCCCCCHH | 18.52 | - | |
| 653 | Phosphorylation | RSRMLELSAPELEPP HHHHHHCCCCCCCCC | 32.19 | 29083192 | |
| 683 | O-linked_Glycosylation | EDYTAQSTPGSANIL CCCCCCCCCCCCCEE | 21.42 | OGP | |
| 755 | Phosphorylation | RCHKGCETCSSRAAT HHCCCCCCCCHHHHH | 23.05 | - | |
| 757 | Phosphorylation | HKGCETCSSRAATQC CCCCCCCCHHHHHHH | 30.22 | - | |
| 815 | Phosphorylation | VDEPEKCTVCKEGFS CCCCHHCCCCCCCCC | 39.75 | 19415658 | |
| 822 | Phosphorylation | TVCKEGFSLARGSCI CCCCCCCCCCCCCCC | 31.79 | 22964224 | |
| 911 (in isoform 8) | Phosphorylation | - | 13.96 | 22210691 | |
| 913 (in isoform 8) | Phosphorylation | - | 50.28 | 22210691 | |
| 914 | N-linked_Glycosylation | SCAGSSRNCSRCKTG HHCCCCCCCCCCCCC | 30.02 | UniProtKB CARBOHYD | |
| 924 (in isoform 7) | Phosphorylation | - | 35.32 | 22210691 | |
| 926 (in isoform 7) | Phosphorylation | - | 13.03 | 22210691 | |
| 932 | N-linked_Glycosylation | LGTSCITNHTCSNAD CCCCHHCCCCCCCCC | 14.46 | UniProtKB CARBOHYD | |
| 933 (in isoform 8) | Phosphorylation | - | 21.43 | 22210691 | |
| 946 (in isoform 7) | Phosphorylation | - | 2.61 | 22210691 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PCSK6_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PCSK6_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PCSK6_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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