SRRM4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRRM4_HUMAN
• UniProt AC: A7MD48
• Protein Name: Serine/arginine repetitive matrix protein 4
• Gene Name: SRRM4
• Organism: Homo sapiens (Human).
• Sequence Length: 611
• Subcellular Localization: Nucleus.
• Protein Description: Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity)..
• Protein Sequence: MASVQQGEKQLFEKFWRGTFKAVATPRPESIIVASITARKPLPRTEPQNNPVVPAQDGPSEKLGQHLATEPLGTNSWERDKTCRELGATRGHSASHDKDLTPPPSSRGKKKKKKSTRKKRRRSSSYSPSPVKKKKKKSSKKHKRRRSFSKKRRHSSSSPKSKRRDEKRHKKQSRSRPRKSHRHRHHRCPSRSQSSESRPSSCESRHRGRSPEEGQKSRRRHSRRCSKTLCKDSPEAQSSRPPSQPLQMLGYLSARGVITGSGSAADLFTKTASPLTTSRGRSQEYDSGNDTSSPPSTQTSSARSRGQEKGSPSGGLSKSRELNSGNTSDSGNSFTTSSPQNKGAMLENLSPTSRGRESRGFQSPCLECAEVKKSSLVPSTARSSPMKGCSRSSSYASTRSSSHSSRSPNPRASPRYTQSRSTSSEKRSYSRSPSYSSKSGKRSPPSRSSRSRRSPSYSRYSPSRERDPKYSEKDSQQRERERARRRRRSYSPMRKRRRDSPSHLEARRITSARKRPIPYYRPSPSSSGSLSSTSSWYSSSSSRSASRSYSRSRSRSRSRRRSRTRTSSSSSSRSPSPGSRSRSRSRSRSRSRSRSQSRSYSSADSYSSTRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	Phosphorylation	VPAQDGPSEKLGQHL CCCCCCCCHHHHHHH	53.55	22210691
74	Phosphorylation	LATEPLGTNSWERDK HCCCCCCCCHHHHCH	33.49	-
76	Phosphorylation	TEPLGTNSWERDKTC CCCCCCCHHHHCHHH	30.10	22210691
93	Phosphorylation	LGATRGHSASHDKDL HCCCCCCCCCCCCCC	34.00	27732954
95	Phosphorylation	ATRGHSASHDKDLTP CCCCCCCCCCCCCCC	34.92	27732954
101	Phosphorylation	ASHDKDLTPPPSSRG CCCCCCCCCCCCHHC	43.83	27732954
105	Phosphorylation	KDLTPPPSSRGKKKK CCCCCCCCHHCCCCC	38.14	27732954
123	Phosphorylation	TRKKRRRSSSYSPSP HHHHHHHHHCCCCCH	23.09	-
125	Phosphorylation	KKRRRSSSYSPSPVK HHHHHHHCCCCCHHC	30.77	-
147	Phosphorylation	KKHKRRRSFSKKRRH HHHHHHHHHHHHHCC	31.87	24719451
173	Phosphorylation	EKRHKKQSRSRPRKS HHHHHHHHHCCCCHH	40.89	28634120
175	Phosphorylation	RHKKQSRSRPRKSHR HHHHHHHCCCCHHHH	52.46	28634120
228	Phosphorylation	HSRRCSKTLCKDSPE HHHHHHHHHHCCCHH	22.54	22617229
243	Phosphorylation	AQSSRPPSQPLQMLG HHHCCCCCCCHHHHH	47.30	27251275
253	Phosphorylation	LQMLGYLSARGVITG HHHHHHHHHCCEECC	13.87	27251275
259	Phosphorylation	LSARGVITGSGSAAD HHHCCEECCCCCHHH	23.92	19276368
261	Phosphorylation	ARGVITGSGSAADLF HCCEECCCCCHHHHH	22.41	27251275
263	Phosphorylation	GVITGSGSAADLFTK CEECCCCCHHHHHHC	23.21	27251275
269	Phosphorylation	GSAADLFTKTASPLT CCHHHHHHCCCCCCC	34.48	29759185
273	Phosphorylation	DLFTKTASPLTTSRG HHHHCCCCCCCCCCC	26.19	27732954
282	Phosphorylation	LTTSRGRSQEYDSGN CCCCCCCCCCCCCCC	30.13	27732954
285	Phosphorylation	SRGRSQEYDSGNDTS CCCCCCCCCCCCCCC	14.05	27732954
287	Phosphorylation	GRSQEYDSGNDTSSP CCCCCCCCCCCCCCC	38.30	27732954
291	Phosphorylation	EYDSGNDTSSPPSTQ CCCCCCCCCCCCCCC	34.79	27732954
292	Phosphorylation	YDSGNDTSSPPSTQT CCCCCCCCCCCCCCC	43.65	22210691
293	Phosphorylation	DSGNDTSSPPSTQTS CCCCCCCCCCCCCCC	42.81	27732954
297	Phosphorylation	DTSSPPSTQTSSARS CCCCCCCCCCCCCHH	41.46	30576142
299	Phosphorylation	SSPPSTQTSSARSRG CCCCCCCCCCCHHCC	25.41	30576142
300	Phosphorylation	SPPSTQTSSARSRGQ CCCCCCCCCCHHCCC	16.51	30576142
301	Phosphorylation	PPSTQTSSARSRGQE CCCCCCCCCHHCCCC	30.96	30576142
317	Phosphorylation	GSPSGGLSKSRELNS CCCCCCCCCCEECCC	31.68	-
350	Phosphorylation	GAMLENLSPTSRGRE CCCCCCCCCCCCCCC	37.40	27732954
352	Phosphorylation	MLENLSPTSRGRESR CCCCCCCCCCCCCCC	27.90	27732954
353	Phosphorylation	LENLSPTSRGRESRG CCCCCCCCCCCCCCC	35.80	27732954
358	Phosphorylation	PTSRGRESRGFQSPC CCCCCCCCCCCCCCH	36.02	24144214
363	Phosphorylation	RESRGFQSPCLECAE CCCCCCCCCHHHHHH	18.47	27732954
379	Phosphorylation	KKSSLVPSTARSSPM HHHHCCCCCCCCCCC	27.50	27732954
380	Phosphorylation	KSSLVPSTARSSPMK HHHCCCCCCCCCCCC	21.74	27732954
383	Phosphorylation	LVPSTARSSPMKGCS CCCCCCCCCCCCCCC	36.01	22210691
384	Phosphorylation	VPSTARSSPMKGCSR CCCCCCCCCCCCCCC	24.38	22210691
390	Phosphorylation	SSPMKGCSRSSSYAS CCCCCCCCCCCCCCC	43.81	30576142
392	Phosphorylation	PMKGCSRSSSYASTR CCCCCCCCCCCCCCC	13.82	26552605
393	Phosphorylation	MKGCSRSSSYASTRS CCCCCCCCCCCCCCC	26.68	30576142
394	Phosphorylation	KGCSRSSSYASTRSS CCCCCCCCCCCCCCC	26.43	26552605
395	Phosphorylation	GCSRSSSYASTRSSS CCCCCCCCCCCCCCC	13.40	22210691
397	Phosphorylation	SRSSSYASTRSSSHS CCCCCCCCCCCCCCC	19.00	26552605
398	Phosphorylation	RSSSYASTRSSSHSS CCCCCCCCCCCCCCC	26.80	26552605
405	Phosphorylation	TRSSSHSSRSPNPRA CCCCCCCCCCCCCCC	31.21	30576142
416	Phosphorylation	NPRASPRYTQSRSTS CCCCCCCCCCCCCCC	16.71	24719451
417	Phosphorylation	PRASPRYTQSRSTSS CCCCCCCCCCCCCCC	22.73	29083192
419	Phosphorylation	ASPRYTQSRSTSSEK CCCCCCCCCCCCCCC	22.02	29083192
421	Phosphorylation	PRYTQSRSTSSEKRS CCCCCCCCCCCCCCC	37.58	29083192
422	Phosphorylation	RYTQSRSTSSEKRSY CCCCCCCCCCCCCCC	34.85	29083192
423	Phosphorylation	YTQSRSTSSEKRSYS CCCCCCCCCCCCCCC	37.43	29083192
424	Phosphorylation	TQSRSTSSEKRSYSR CCCCCCCCCCCCCCC	47.42	29083192
429	Phosphorylation	TSSEKRSYSRSPSYS CCCCCCCCCCCCCCC	16.49	-
438	Ubiquitination	RSPSYSSKSGKRSPP CCCCCCCCCCCCCCC	58.23	-
443	Phosphorylation	SSKSGKRSPPSRSSR CCCCCCCCCCCCCCC	44.65	20393185
446	Phosphorylation	SGKRSPPSRSSRSRR CCCCCCCCCCCCCCC	48.45	23312004
448	Phosphorylation	KRSPPSRSSRSRRSP CCCCCCCCCCCCCCC	34.15	28674151
449	Phosphorylation	RSPPSRSSRSRRSPS CCCCCCCCCCCCCCC	32.91	28674151
451	Phosphorylation	PPSRSSRSRRSPSYS CCCCCCCCCCCCCCC	33.71	23312004
454	Phosphorylation	RSSRSRRSPSYSRYS CCCCCCCCCCCCCCC	19.65	20363803
456	Phosphorylation	SRSRRSPSYSRYSPS CCCCCCCCCCCCCCC	36.67	20363803
457	Phosphorylation	RSRRSPSYSRYSPSR CCCCCCCCCCCCCCC	10.68	23312004
458	Phosphorylation	SRRSPSYSRYSPSRE CCCCCCCCCCCCCCC	29.13	20363803
460	Phosphorylation	RSPSYSRYSPSRERD CCCCCCCCCCCCCCC	20.99	-
461	Phosphorylation	SPSYSRYSPSRERDP CCCCCCCCCCCCCCC	18.45	-
463	Phosphorylation	SYSRYSPSRERDPKY CCCCCCCCCCCCCCC	40.61	17081983
500	Phosphorylation	MRKRRRDSPSHLEAR HHHHCCCCCCHHHHH	26.87	27732954
525	Phosphorylation	PYYRPSPSSSGSLSS CCCCCCCCCCCCCCC	41.28	30576142
526	Phosphorylation	YYRPSPSSSGSLSST CCCCCCCCCCCCCCC	41.94	30576142
527	Phosphorylation	YRPSPSSSGSLSSTS CCCCCCCCCCCCCCC	36.42	-
532	Phosphorylation	SSSGSLSSTSSWYSS CCCCCCCCCCCCCCC	37.29	30576142
534	Phosphorylation	SGSLSSTSSWYSSSS CCCCCCCCCCCCCCC	22.33	-
535	Phosphorylation	GSLSSTSSWYSSSSS CCCCCCCCCCCCCCC	30.07	-
542	Phosphorylation	SWYSSSSSRSASRSY CCCCCCCCCCCCCHH	32.00	-
546	Phosphorylation	SSSSRSASRSYSRSR CCCCCCCCCHHHHHH	24.01	20068231
548	Phosphorylation	SSRSASRSYSRSRSR CCCCCCCHHHHHHHH	25.60	20068231
549	Phosphorylation	SRSASRSYSRSRSRS CCCCCCHHHHHHHHH	13.64	20068231
550	Phosphorylation	RSASRSYSRSRSRSR CCCCCHHHHHHHHHH	25.65	20363803
552	Phosphorylation	ASRSYSRSRSRSRSR CCCHHHHHHHHHHHH	28.77	20363803
556	Phosphorylation	YSRSRSRSRSRRRSR HHHHHHHHHHHHHCC	35.54	-
566	Phosphorylation	RRRSRTRTSSSSSSR HHHCCCCCCCCCCCC	32.14	22210691
570	Phosphorylation	RTRTSSSSSSRSPSP CCCCCCCCCCCCCCC	33.99	-
571	Phosphorylation	TRTSSSSSSRSPSPG CCCCCCCCCCCCCCC	31.55	-
579	Phosphorylation	SRSPSPGSRSRSRSR CCCCCCCCHHHHHHH	30.39	20363803
581	Phosphorylation	SPSPGSRSRSRSRSR CCCCCCHHHHHHHHH	35.98	26074081
583	Phosphorylation	SPGSRSRSRSRSRSR CCCCHHHHHHHHHHH	35.54	26074081
585	Phosphorylation	GSRSRSRSRSRSRSR CCHHHHHHHHHHHHH	35.54	26074081
587	Phosphorylation	RSRSRSRSRSRSRSR HHHHHHHHHHHHHCH	35.54	26074081
589	Phosphorylation	RSRSRSRSRSRSRSQ HHHHHHHHHHHCHHH	35.54	26074081
591	Phosphorylation	RSRSRSRSRSRSQSR HHHHHHHHHCHHHCC	35.54	20363803
593	Phosphorylation	RSRSRSRSRSQSRSY HHHHHHHCHHHCCCC	37.21	20363803
597	Phosphorylation	RSRSRSQSRSYSSAD HHHCHHHCCCCCCCC	25.17	20363803
600	Phosphorylation	SRSQSRSYSSADSYS CHHHCCCCCCCCCCC	12.92	-
601	Phosphorylation	RSQSRSYSSADSYSS HHHCCCCCCCCCCCC	21.94	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRRM4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRRM4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRRM4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SRRM4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.