KLHL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLHL1_HUMAN
• UniProt AC: Q9NR64
• Protein Name: Kelch-like protein 1
• Gene Name: KLHL1
• Organism: Homo sapiens (Human).
• Sequence Length: 748
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: May play a role in organizing the actin cytoskeleton of the brain cells..
• Protein Sequence: MSGSGRKDFDVKHILRLRWKLFSHPSPSTGGPAGGGCLQQDGSGSFEHWGPSQSRLLKSQERSGVSTFWKKPSSSSSSSSSPSSSSSSFNPLNGTLLPVATRLQQGAPGQGTQQPARTLFYVESLEEEVVPGMDFPGPHEKGLVLQELKVEPDNSSQATGEGCGHRLSSTGHSMTPQSDLDSSSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILADLENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIKQP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	LFSHPSPSTGGPAGG ECCCCCCCCCCCCCC	43.98	22210691
45	Phosphorylation	LQQDGSGSFEHWGPS CCCCCCCCCCCCCCC	29.20	22210691
52	Phosphorylation	SFEHWGPSQSRLLKS CCCCCCCCHHHHHHH	36.53	22210691
75	Phosphorylation	FWKKPSSSSSSSSSP EEECCCCCCCCCCCC	38.28	-
76	Phosphorylation	WKKPSSSSSSSSSPS EECCCCCCCCCCCCC	35.87	-
77	Phosphorylation	KKPSSSSSSSSSPSS ECCCCCCCCCCCCCC	35.87	-
78	Phosphorylation	KPSSSSSSSSSPSSS CCCCCCCCCCCCCCC	35.87	-
156	Phosphorylation	KVEPDNSSQATGEGC EECCCCCCCCCCCCC	30.04	-
444	Phosphorylation	HLLPERRTLMQSPRT CCCHHHHHHHCCCCC	32.57	29449344
444	O-linked_Glycosylation	HLLPERRTLMQSPRT CCCHHHHHHHCCCCC	32.57	30379171
448	Phosphorylation	ERRTLMQSPRTKPRK HHHHHHCCCCCCCCC	11.46	29449344
518	Ubiquitination	IGGRDGLKTLNTVEC EECCCCCCCCCEEEE	57.40	-
519	Phosphorylation	GGRDGLKTLNTVECY ECCCCCCCCCEEEEE	30.22	28509920
522	Phosphorylation	DGLKTLNTVECYNPK CCCCCCCEEEEECCC	22.31	28509920
526	Phosphorylation	TLNTVECYNPKTKTW CCCEEEEECCCCCEE	22.46	28509920
529	Ubiquitination	TVECYNPKTKTWTVL EEEEECCCCCEEEEC	60.04	-
530	Phosphorylation	VECYNPKTKTWTVLP EEEECCCCCEEEECC	34.66	-
532	Phosphorylation	CYNPKTKTWTVLPPM EECCCCCEEEECCCC	31.44	-
556	Phosphorylation	TVLEGPIYAVGGHDG EEEECCEEEECCCCC	9.81	-
591	Phosphorylation	ASMSIARSTVGVAAL EEHHHHHHHHHHEEE	20.58	22210691
604	Phosphorylation	ALNGKLYSVGGRDGS EECCEEEEECCCCCC	25.40	22210691
624	Phosphorylation	MEYYDPHTNKWNMCA CCEECCCCCCCCCCH	43.83	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLHL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLHL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLHL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAC1A_HUMAN	CACNA1A	physical	17289272
GSK3B_RAT	Gsk3b	physical	16982692
CSK_RAT	Csk	physical	16982692

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.