| UniProt ID | NELL1_HUMAN | |
|---|---|---|
| UniProt AC | Q92832 | |
| Protein Name | Protein kinase C-binding protein NELL1 | |
| Gene Name | NELL1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 810 | |
| Subcellular Localization | Cytoplasm . Nucleus envelope . Secreted. Colocalizes with ATRAID on the nuclear envelope and the perinuclear region. | |
| Protein Description | Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.. | |
| Protein Sequence | MPMDLILVVWFCVCTARTVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIEREIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSGLRDEIRYHYIHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDTNLPPGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGIMDLQELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCCSVDFECLQNN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 40 | N-linked_Glycosylation | VTELDLVNTTLGVAQ EEHHHHHHCCCCHHC | 34.34 | UniProtKB CARBOHYD | |
| 53 | N-linked_Glycosylation | AQVSGMHNASKAFLF HCCCCCCCCCEEHHH | 36.70 | UniProtKB CARBOHYD | |
| 83 | N-linked_Glycosylation | KLIQLFRNKSEFTIL HHHHHHCCCCCEEEE | 44.89 | UniProtKB CARBOHYD | |
| 105 | Phosphorylation | STSGVILSIRELEHS CCCCEEEEEEEEECE | 14.42 | - | |
| 224 | N-linked_Glycosylation | ITQCPNLNHTCPTCS EEECCCCCCCCCCHH | 34.75 | UniProtKB CARBOHYD | |
| 294 | N-linked_Glycosylation | VDGDHCRNCTCKSGA CCCCCCCCCCCCCCC | 30.74 | UniProtKB CARBOHYD | |
| 340 | Ubiquitination | PKCIYGGKVLAEGQR CCCEECCEEEEECCE | 29.70 | - | |
| 351 | Ubiquitination | EGQRILTKSCRECRG ECCEEECHHHHHCCC | 44.08 | - | |
| 372 | N-linked_Glycosylation | TEMCPPLNCSEKDHI EECCCCCCCCCCCCC | 32.80 | UniProtKB CARBOHYD | |
| 511 | N-linked_Glycosylation | CKPGYVGNGTICRAF ECCCCCCCCCEEHHH | 34.10 | UniProtKB CARBOHYD | |
| 562 | N-linked_Glycosylation | EGIIECHNHSRCVNL CCHHEECCCCCCCCC | 46.63 | UniProtKB CARBOHYD | |
| 609 | N-linked_Glycosylation | LRTHTCWNDSACINL ECCCCCCCCCCCEEE | 35.19 | UniProtKB CARBOHYD | |
| 708 | N-linked_Glycosylation | KLYRSGDNWTHSCQQ EEEECCCCCCCCCCC | 49.42 | UniProtKB CARBOHYD | |
| 732 | N-linked_Glycosylation | CWPLTCPNLSCEYTA EEEEECCCCCEEEEE | 46.89 | UniProtKB CARBOHYD | |
| 758 | N-linked_Glycosylation | SDPCLADNITYDIRK CCCCCCCCCEEEHHH | 23.93 | UniProtKB CARBOHYD |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NELL1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NELL1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NELL1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MATN2_HUMAN | MATN2 | physical | 28514442 | |
| PFKAP_HUMAN | PFKP | physical | 28514442 | |
| FBX27_HUMAN | FBXO27 | physical | 28514442 | |
| PXDN_HUMAN | PXDN | physical | 28514442 | |
| ZN260_HUMAN | ZNF260 | physical | 28514442 | |
| TRM2_HUMAN | TRMT2B | physical | 28514442 | |
| EMIL2_HUMAN | EMILIN2 | physical | 28514442 | |
| PRPK_HUMAN | TP53RK | physical | 28514442 | |
| TIMP3_HUMAN | TIMP3 | physical | 28514442 | |
| EGFL7_HUMAN | EGFL7 | physical | 28514442 | |
| RPOM_HUMAN | POLRMT | physical | 28514442 | |
| TYW3_HUMAN | TYW3 | physical | 28514442 | |
| LTBP4_HUMAN | LTBP4 | physical | 28514442 | |
| CEP44_HUMAN | CEP44 | physical | 28514442 | |
| FBLN1_HUMAN | FBLN1 | physical | 28514442 | |
| LAMB2_HUMAN | LAMB2 | physical | 28514442 | |
| OBSL1_HUMAN | OBSL1 | physical | 28514442 | |
| CJ088_HUMAN | C10orf88 | physical | 28514442 | |
| CHK1_HUMAN | CHEK1 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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