ZN260_HUMAN - dbPTM
ZN260_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZN260_HUMAN
UniProt AC Q3ZCT1
Protein Name Zinc finger protein 260
Gene Name ZNF260
Organism Homo sapiens (Human).
Sequence Length 412
Subcellular Localization Nucleus .
Protein Description Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator (By similarity)..
Protein Sequence MIGMLESLQHESDLLQHDQIHTGEKPYECNECRKTFSLKQNLVEHKKMHTGEKSHECTECGKVCSRVSSLTLHLRSHTGKKAYKCNKCGKAFSQKENFLSHQKHHTGEKPYECEKVSIQMPTIIRHQKNHTGTKPYACKECGKAFNGKAYLTEHEKIHTGEKPFECNQCGRAFSQKQYLIKHQNIHTGKKPFKCSECGKAFSQKENLIIHQRIHTGEKPYECKGCGKAFIQKSSLIRHQRSHTGEKPYTCKECGKAFSGKSNLTEHEKIHIGEKPYKCNECGTIFRQKQYLIKHHNIHTGEKPYECNKCGKAFSRITSLIVHVRIHTGDKPYECKVCGKAFCQSSSLTVHMRSHTGEKPYGCNECGKAFSQFSTLALHMRIHTGEKPYQCSECGKAFSQKSHHIRHQRIHTH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
22PhosphorylationLQHDQIHTGEKPYEC
HHCCCCCCCCCCCCC		48.9828655764
47AcetylationQNLVEHKKMHTGEKS
HHHHHHHCCCCCCCC		37.51164183
68PhosphorylationGKVCSRVSSLTLHLR
HHHHHHHHHHHEEEH		20.6524719451
69PhosphorylationKVCSRVSSLTLHLRS
HHHHHHHHHHEEEHH		23.6323403867
71PhosphorylationCSRVSSLTLHLRSHT
HHHHHHHHEEEHHCC		17.6823403867
84UbiquitinationHTGKKAYKCNKCGKA
CCCCCEEECCCCCCC		35.87-
87UbiquitinationKKAYKCNKCGKAFSQ
CCEEECCCCCCCHHH		54.56-
90AcetylationYKCNKCGKAFSQKEN
EECCCCCCCHHHHHH		56.5820167786
95UbiquitinationCGKAFSQKENFLSHQ
CCCCHHHHHHHHHCC		54.12-
134UbiquitinationQKNHTGTKPYACKEC
CCCCCCCCCEECHHH		37.06-
159PhosphorylationTEHEKIHTGEKPFEC
CCCCCCCCCCCCCCC		50.9728555341
176UbiquitinationCGRAFSQKQYLIKHQ
CCCCHHHHHHHHHCC		39.45-
204UbiquitinationCGKAFSQKENLIIHQ
CCCCCCCCCCEEEEE		47.5821890473
215PhosphorylationIIHQRIHTGEKPYEC
EEEEEECCCCCCCCC		44.6729496963
232UbiquitinationCGKAFIQKSSLIRHQ
CCCEEECHHHHHHCC		36.88-
234PhosphorylationKAFIQKSSLIRHQRS
CEEECHHHHHHCCCC		34.5524719451
241PhosphorylationSLIRHQRSHTGEKPY
HHHHCCCCCCCCCCE		20.87-
243PhosphorylationIRHQRSHTGEKPYTC
HHCCCCCCCCCCEEC		48.56-
248PhosphorylationSHTGEKPYTCKECGK
CCCCCCCEECCCCCC		35.52-
249PhosphorylationHTGEKPYTCKECGKA
CCCCCCEECCCCCCC		26.15-
268UbiquitinationSNLTEHEKIHIGEKP
CCCCCCCCEECCCCC		41.30-
274UbiquitinationEKIHIGEKPYKCNEC
CCEECCCCCCCCCCC		48.73-
288UbiquitinationCGTIFRQKQYLIKHH
CCCHHHCHHHHHHCC		36.33-
293AcetylationRQKQYLIKHHNIHTG
HCHHHHHHCCCCCCC		35.907674107
299PhosphorylationIKHHNIHTGEKPYEC
HHCCCCCCCCCCCCC		43.15-
302AcetylationHNIHTGEKPYECNKC
CCCCCCCCCCCCCCC		55.007674117
318PhosphorylationKAFSRITSLIVHVRI
HHHHHHHHEEEEEEE		17.4628348404
324MethylationTSLIVHVRIHTGDKP
HHEEEEEEECCCCCC		10.49-
327PhosphorylationIVHVRIHTGDKPYEC
EEEEEECCCCCCEEE		44.7128348404
330UbiquitinationVRIHTGDKPYECKVC
EEECCCCCCEEEEEC		51.33-
355PhosphorylationTVHMRSHTGEKPYGC
EEEECCCCCCCCCCC		48.5629496963
358UbiquitinationMRSHTGEKPYGCNEC
ECCCCCCCCCCCCCC		44.90-
383PhosphorylationALHMRIHTGEKPYQC
HHHCCCCCCCCCEEC		44.6728111955
386SumoylationMRIHTGEKPYQCSEC
CCCCCCCCCEECCCC		50.82-
386SumoylationMRIHTGEKPYQCSEC
CCCCCCCCCEECCCC		50.82-
395UbiquitinationYQCSECGKAFSQKSH
EECCCCHHHHHCCCH		58.90-
400SumoylationCGKAFSQKSHHIRHQ
CHHHHHCCCHHHCCC		51.03-
400SumoylationCGKAFSQKSHHIRHQ
CHHHHHCCCHHHCCC		51.03-
400UbiquitinationCGKAFSQKSHHIRHQ
CHHHHHCCCHHHCCC		51.03-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZN260_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZN260_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZN260_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ZN260_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZN260_HUMAN

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Related Literatures of Post-Translational Modification

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