| UniProt ID | NELL2_HUMAN | |
|---|---|---|
| UniProt AC | Q99435 | |
| Protein Name | Protein kinase C-binding protein NELL2 | |
| Gene Name | NELL2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 816 | |
| Subcellular Localization | Secreted . | |
| Protein Description | Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity).. | |
| Protein Sequence | MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 50 (in isoform 2) | Phosphorylation | - | 40.49 | 22210691 | |
| 53 | N-linked_Glycosylation | RQVPGLHNGTKAFLF CCCCCCCCCCEEEEE | 65.94 | UniProtKB CARBOHYD | |
| 65 (in isoform 2) | Phosphorylation | - | 53.78 | 22210691 | |
| 66 (in isoform 2) | Phosphorylation | - | 29.64 | 22210691 | |
| 77 (in isoform 3) | Phosphorylation | - | 5.43 | 22210691 | |
| 92 (in isoform 3) | Phosphorylation | - | 25.45 | 22210691 | |
| 93 (in isoform 3) | Phosphorylation | - | 2.78 | 22210691 | |
| 225 | N-linked_Glycosylation | IAQCPDLNRTCPTCN HHCCCCCCCCCCCCC | 44.59 | UniProtKB CARBOHYD | |
| 273 | O-linked_Glycosylation | DQCYCERTCTMKGTT HHHHHHCCCCCCCCC | 7.05 | 29237092 | |
| 275 | O-linked_Glycosylation | CYCERTCTMKGTTYR HHHHCCCCCCCCCHH | 22.70 | 29237092 | |
| 293 | N-linked_Glycosylation | SWIDGCKNCTCLNGT HHHCCCCCCCEECCE | 30.33 | UniProtKB CARBOHYD | |
| 298 | N-linked_Glycosylation | CKNCTCLNGTIQCET CCCCCEECCEEEEEE | 47.94 | UniProtKB CARBOHYD | |
| 350 | Phosphorylation | EGERNTVYSSSGVCV ECCCCEEEECCCEEE | 10.78 | - | |
| 359 | Phosphorylation | SSGVCVLYECKDQTM CCCEEEEEEECCCEE | 10.01 | - | |
| 517 | N-linked_Glycosylation | CKPGYTGNGTTCKAF ECCCCCCCCCCEEEE | 36.52 | UniProtKB CARBOHYD | |
| 615 | N-linked_Glycosylation | TGRHSCANDTICFNL CCCCCCCCCEEEEEC | 51.81 | UniProtKB CARBOHYD | |
| 635 | N-linked_Glycosylation | CRCPHGKNCTGDCIH CCCCCCCCCCCCCEE | 32.92 | UniProtKB CARBOHYD | |
| 770 | Phosphorylation | DTIRNDITKTCLDEM HHHCHHHHHHHHHHC | 24.14 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NELL2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NELL2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NELL2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| EMIL2_HUMAN | EMILIN2 | physical | 28514442 | |
| MATN2_HUMAN | MATN2 | physical | 28514442 | |
| ZBT40_HUMAN | ZBTB40 | physical | 28514442 | |
| ZN101_HUMAN | ZNF101 | physical | 28514442 | |
| ZBTB9_HUMAN | ZBTB9 | physical | 28514442 | |
| POC1A_HUMAN | POC1A | physical | 28514442 | |
| PAX3_HUMAN | PAX3 | physical | 28514442 | |
| CEP44_HUMAN | CEP44 | physical | 28514442 | |
| ZN627_HUMAN | ZNF627 | physical | 28514442 | |
| RPOM_HUMAN | POLRMT | physical | 28514442 | |
| ZN136_HUMAN | ZNF136 | physical | 28514442 | |
| POC1B_HUMAN | POC1B | physical | 28514442 | |
| EGFL7_HUMAN | EGFL7 | physical | 28514442 | |
| SEH1_HUMAN | SEH1L | physical | 28514442 | |
| TYW3_HUMAN | TYW3 | physical | 28514442 | |
| PXDN_HUMAN | PXDN | physical | 28514442 | |
| CTC1_HUMAN | CTC1 | physical | 28514442 | |
| ASPH_HUMAN | ASPH | physical | 28514442 | |
| COR1A_HUMAN | CORO1A | physical | 28514442 | |
| BRE1B_HUMAN | RNF40 | physical | 28514442 | |
| KI18B_HUMAN | KIF18B | physical | 28514442 | |
| TRAF7_HUMAN | TRAF7 | physical | 28514442 | |
| ATIF1_HUMAN | ATPIF1 | physical | 28514442 | |
| LTBP4_HUMAN | LTBP4 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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