dbPTM

KI18B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KI18B_HUMAN
UniProt AC	Q86Y91
Protein Name	Kinesin-like protein KIF18B
Gene Name	KIF18B
Organism	Homo sapiens (Human).
Sequence Length	864
Subcellular Localization	Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Present predominantly in the nucleus and to a lesser extent in the cytoplasm of interphase cells. During mitosis, found to be closely associated with astral microtubule plus ends emanating from the spindle
Protein Description	In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules..
Protein Sequence	MSHPGVTTVMAVEDSTLQVVVRVRPPTPRELDSQRRPVVQVVDERVLVFNPEEPDGGFPGLKWGGTHDGPKKKGKDLTFVFDRVFGEAATQQDVFQHTTHSVLDSFLQGYNCSVFAYGATGAGKTHTMLGREGDPGIMYLTTVELYRRLEARQQEKHFEVLISYQEVYNEQIHDLLEPKGPLAIREDPDKGVVVQGLSFHQPASAEQLLEILTRGNRNRTQHPTDANATSSRSHAIFQIFVKQQDRVPGLTQAVQVAKMSLIDLAGSERASSTHAKGERLREGANINRSLLALINVLNALADAKGRKTHVPYRDSKLTRLLKDSLGGNCRTVMIAAISPSSLTYEDTYNTLKYADRAKEIRLSLKSNVTSLDCHISQYATICQQLQAEVAALRKKLQVYEGGGQPPPQDLPGSPKSGPPPEHLPSSPLPPHPPSQPCTPELPAGPRALQEESLGMEAQVERAMEGNSSDQEQSPEDEDEGPAEEVPTQMPEQNPTHALPESPRLTLQPKPVVGHFSARELDGDRSKQLALKVLCVAQRQYSLLQAANLLTPDMITEFETLQQLVQEEKIEPGAEALRTSGLARGAPLAQELCSESKPPGYTGPVTRTMARRLSGPLHTLGIPPGPNCTPAQGSRWPMEKKRRRPSALEADSPMAPKRGTKRQRQSFLPCLRRGSLPDTQPSQGPSTPKGERASSPCHSPRVCPATVIKSRVPLGPSAMQNCSTPLALPTRDLNATFDLSEEPPSKPSFHECIGWDKIPQELSRLDQPFIPRAPVPLFTMKGPKPTSSLPGTSACKKKRVASSSVSHGRSRIARLPSSTLKRPAGPLVLPELPLSPLCPSNRRNGKDLIRVGRALSAGNGVTKVS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSHPGVTTV ------CCCCCCEEE	38.09	24043423
7	Phosphorylation	-MSHPGVTTVMAVED -CCCCCCEEEEEEEC	21.42	24043423
8	Phosphorylation	MSHPGVTTVMAVEDS CCCCCCEEEEEEECC	13.08	24043423
15	Phosphorylation	TVMAVEDSTLQVVVR EEEEEECCEEEEEEE	19.94	24043423
16	Phosphorylation	VMAVEDSTLQVVVRV EEEEECCEEEEEEEE	33.27	20068231
27	Phosphorylation	VVRVRPPTPRELDSQ EEEECCCCHHHCCCC	37.35	24043423
53 (in isoform 1)	Ubiquitination	-	50.37	21906983
53 (in isoform 2)	Ubiquitination	-	50.37	21906983
62	Ubiquitination	DGGFPGLKWGGTHDG CCCCCCCCCCCCCCC	50.11	-
62 (in isoform 4)	Ubiquitination	-	50.11	-
75 (in isoform 4)	Ubiquitination	-	59.45	-
198	Phosphorylation	GVVVQGLSFHQPASA CEEEEEEEECCCCCH	27.75	-
246	Methylation	IFVKQQDRVPGLTQA EEECCHHCCCCHHHH	31.99	115481117
267	Phosphorylation	SLIDLAGSERASSTH HHHHHCCCCCCCCCC	20.50	22798277
271	Phosphorylation	LAGSERASSTHAKGE HCCCCCCCCCCCCCC	41.83	22798277
304	Ubiquitination	LNALADAKGRKTHVP HHHHHHHCCCCCCCC	60.85	-
316 (in isoform 4)	Ubiquitination	-	59.16	-
322 (in isoform 4)	Ubiquitination	-	50.27	-
341	Phosphorylation	IAAISPSSLTYEDTY EEEECCHHCCHHHHH	28.28	-
352 (in isoform 4)	Ubiquitination	-	36.03	-
363	Phosphorylation	RAKEIRLSLKSNVTS HHHHHHHHHHCCCCC	24.73	27174698
366	Phosphorylation	EIRLSLKSNVTSLDC HHHHHHHCCCCCCHH	41.65	27174698
369	Phosphorylation	LSLKSNVTSLDCHIS HHHHCCCCCCHHHHH	28.02	27174698
370	Phosphorylation	SLKSNVTSLDCHISQ HHHCCCCCCHHHHHH	20.23	27174698
376	Phosphorylation	TSLDCHISQYATICQ CCCHHHHHHHHHHHH	8.09	27174698
378	Phosphorylation	LDCHISQYATICQQL CHHHHHHHHHHHHHH	10.02	27174698
380	Phosphorylation	CHISQYATICQQLQA HHHHHHHHHHHHHHH	19.83	27174698
395 (in isoform 4)	Ubiquitination	-	37.40	-
399	Phosphorylation	LRKKLQVYEGGGQPP HHHHCCEECCCCCCC	8.90	29396449
404	Phosphorylation	QVYEGGGQPPPQDLP CEECCCCCCCCCCCC	51.07	18691976
413	Phosphorylation	PPQDLPGSPKSGPPP CCCCCCCCCCCCCCC	27.49	29255136
416	Phosphorylation	DLPGSPKSGPPPEHL CCCCCCCCCCCCCCC	60.97	27273156
417	Phosphorylation	LPGSPKSGPPPEHLP CCCCCCCCCCCCCCC	44.88	18691976
425	Phosphorylation	PPPEHLPSSPLPPHP CCCCCCCCCCCCCCC	51.45	27273156
426	Phosphorylation	PPEHLPSSPLPPHPP CCCCCCCCCCCCCCC	28.63	25159151
434	Phosphorylation	PLPPHPPSQPCTPEL CCCCCCCCCCCCCCC	51.73	27273156
438	Phosphorylation	HPPSQPCTPELPAGP CCCCCCCCCCCCCCH	26.87	27273156
452	Phosphorylation	PRALQEESLGMEAQV HHHHHHHHHCHHHHH	29.48	19691289
467	Phosphorylation	ERAMEGNSSDQEQSP HHHHCCCCCCCCCCC	46.26	18691976
468	Phosphorylation	RAMEGNSSDQEQSPE HHHCCCCCCCCCCCC	47.52	30576142
473	Phosphorylation	NSSDQEQSPEDEDEG CCCCCCCCCCCCCCC	29.51	17192257
480	Phosphorylation	SPEDEDEGPAEEVPT CCCCCCCCCHHHCCC	38.75	18691976
487	Phosphorylation	GPAEEVPTQMPEQNP CCHHHCCCCCCCCCC	42.55	30175587
495	Phosphorylation	QMPEQNPTHALPESP CCCCCCCCCCCCCCC	27.59	18691976
501	Phosphorylation	PTHALPESPRLTLQP CCCCCCCCCCCCCCC	17.24	17192257
516	Phosphorylation	KPVVGHFSARELDGD CCEECEEECHHCCCH	22.27	28555341
531 (in isoform 4)	Ubiquitination	-	27.79	-
558	Phosphorylation	PDMITEFETLQQLVQ HHHHHHHHHHHHHHH	42.23	23186163
578	Phosphorylation	PGAEALRTSGLARGA CCHHHHHHHCCCCCC	28.17	17192257
579	Phosphorylation	GAEALRTSGLARGAP CHHHHHHHCCCCCCH	25.94	21815630
579	Phosphorylation	GAEALRTSGLARGAP CHHHHHHHCCCCCCH	25.94	20860994
583	Methylation	LRTSGLARGAPLAQE HHHHCCCCCCHHHHH	47.01	115481125
588	Phosphorylation	LARGAPLAQELCSES CCCCCHHHHHHHHCC	10.35	28634298
588 (in isoform 3)	Phosphorylation	-	10.35	21815630
589	Phosphorylation	ARGAPLAQELCSESK CCCCHHHHHHHHCCC	52.45	28634298
591	Phosphorylation	GAPLAQELCSESKPP CCHHHHHHHHCCCCC	2.30	21815630
593	Phosphorylation	PLAQELCSESKPPGY HHHHHHHHCCCCCCC	58.49	28634298
593	Phosphorylation	PLAQELCSESKPPGY HHHHHHHHCCCCCCC	58.49	28555341
597 (in isoform 3)	Phosphorylation	-	36.51	28634298
598 (in isoform 3)	Phosphorylation	-	52.76	28634298
600	Phosphorylation	SESKPPGYTGPVTRT HCCCCCCCCCHHHHH	17.81	28634298
600 (in isoform 2)	Phosphorylation	-	17.81	21815630
600 (in isoform 4)	Phosphorylation	-	17.81	21815630
601	Phosphorylation	ESKPPGYTGPVTRTM CCCCCCCCCHHHHHH	40.71	28634298
602 (in isoform 3)	Phosphorylation	-	13.24	28634298
605	Phosphorylation	PGYTGPVTRTMARRL CCCCCHHHHHHHHHH	24.45	28634298
605	Phosphorylation	PGYTGPVTRTMARRL CCCCCHHHHHHHHHH	24.45	30631047
607	Phosphorylation	YTGPVTRTMARRLSG CCCHHHHHHHHHHCC	13.05	30631047
609 (in isoform 2)	Phosphorylation	-	7.88	28634298
609 (in isoform 4)	Phosphorylation	-	7.88	28634298
610 (in isoform 2)	Phosphorylation	-	29.29	28634298
610 (in isoform 4)	Phosphorylation	-	29.29	28634298
613	Phosphorylation	RTMARRLSGPLHTLG HHHHHHHCCCCCCCC	36.23	27174698
614 (in isoform 2)	Phosphorylation	-	33.12	28634298
614 (in isoform 4)	Phosphorylation	-	33.12	28634298
618	Phosphorylation	RLSGPLHTLGIPPGP HHCCCCCCCCCCCCC	34.07	30576142
628	Phosphorylation	IPPGPNCTPAQGSRW CCCCCCCCCCCCCCC	28.44	30576142
633	Phosphorylation	NCTPAQGSRWPMEKK CCCCCCCCCCCCHHC	21.06	30576142
639	Phosphorylation	GSRWPMEKKRRRPSA CCCCCCHHCCCCCCH	45.38	18691976
645	Phosphorylation	EKKRRRPSALEADSP HHCCCCCCHHHCCCC	43.61	27273156
651	Phosphorylation	PSALEADSPMAPKRG CCHHHCCCCCCCCCC	24.51	29255136
659	Phosphorylation	PMAPKRGTKRQRQSF CCCCCCCCHHHHHHH	27.38	27251275
662	Phosphorylation	PKRGTKRQRQSFLPC CCCCCHHHHHHHHHH	49.69	18220336
665	Phosphorylation	GTKRQRQSFLPCLRR CCHHHHHHHHHHHHH	30.82	21815630
674	Phosphorylation	LPCLRRGSLPDTQPS HHHHHHCCCCCCCCC	34.61	25159151
678	Phosphorylation	RRGSLPDTQPSQGPS HHCCCCCCCCCCCCC	40.20	30266825
681	Phosphorylation	SLPDTQPSQGPSTPK CCCCCCCCCCCCCCC	37.64	21712546
685	Phosphorylation	TQPSQGPSTPKGERA CCCCCCCCCCCCCCC	65.25	30266825
686	Phosphorylation	QPSQGPSTPKGERAS CCCCCCCCCCCCCCC	31.95	30266825
688	Ubiquitination	SQGPSTPKGERASSP CCCCCCCCCCCCCCC	73.77	21906983
688 (in isoform 1)	Ubiquitination	-	73.77	21906983
688 (in isoform 2)	Ubiquitination	-	73.77	21906983
693	Phosphorylation	TPKGERASSPCHSPR CCCCCCCCCCCCCCC	40.82	25849741
694	Phosphorylation	PKGERASSPCHSPRV CCCCCCCCCCCCCCC	30.48	25159151
698	Phosphorylation	RASSPCHSPRVCPAT CCCCCCCCCCCCCCE	22.55	25849741
705	Phosphorylation	SPRVCPATVIKSRVP CCCCCCCEEEECCCC	14.12	23312004
716	Phosphorylation	SRVPLGPSAMQNCST CCCCCCHHHHHCCCC	34.28	27732954
722	Phosphorylation	PSAMQNCSTPLALPT HHHHHCCCCCCCCCC	40.38	30576142
723	Phosphorylation	SAMQNCSTPLALPTR HHHHCCCCCCCCCCC	25.23	21815630
729	Phosphorylation	STPLALPTRDLNATF CCCCCCCCCCCCCCC	37.35	29978859
762	Phosphorylation	DKIPQELSRLDQPFI HHCCHHHHCCCCCCC	30.00	28555341
783	Ubiquitination	LFTMKGPKPTSSLPG EEECCCCCCCCCCCC	70.38	21906983
783 (in isoform 1)	Ubiquitination	-	70.38	21906983
783 (in isoform 2)	Ubiquitination	-	70.38	21906983
787	Phosphorylation	KGPKPTSSLPGTSAC CCCCCCCCCCCCCHH	40.85	28674419
791	Phosphorylation	PTSSLPGTSACKKKR CCCCCCCCCHHCCCC	15.94	25159151
792	Phosphorylation	TSSLPGTSACKKKRV CCCCCCCCHHCCCCC	37.27	28985074
795	Acetylation	LPGTSACKKKRVASS CCCCCHHCCCCCCCC	62.13	25953088
795	Ubiquitination	LPGTSACKKKRVASS CCCCCHHCCCCCCCC	62.13	21906983
795 (in isoform 1)	Ubiquitination	-	62.13	21906983
795 (in isoform 2)	Ubiquitination	-	62.13	21906983
796	Ubiquitination	PGTSACKKKRVASSS CCCCHHCCCCCCCCC	45.77	21906983
796 (in isoform 1)	Ubiquitination	-	45.77	21906983
796 (in isoform 2)	Ubiquitination	-	45.77	21906983
801	Phosphorylation	CKKKRVASSSVSHGR HCCCCCCCCCHHCCC	21.93	-
803	Phosphorylation	KKRVASSSVSHGRSR CCCCCCCCHHCCCHH	25.74	-
816	Phosphorylation	SRIARLPSSTLKRPA HHHCCCCCCCCCCCC	40.31	29978859
817	Phosphorylation	RIARLPSSTLKRPAG HHCCCCCCCCCCCCC	35.50	29978859
818	Phosphorylation	IARLPSSTLKRPAGP HCCCCCCCCCCCCCC	40.41	29978859
822	Phosphorylation	PSSTLKRPAGPLVLP CCCCCCCCCCCCCCC	39.73	18691976
834	Phosphorylation	VLPELPLSPLCPSNR CCCCCCCCCCCCCCC	17.56	30266825
839	Phosphorylation	PLSPLCPSNRRNGKD CCCCCCCCCCCCCCC	41.81	30266825
855	Phosphorylation	IRVGRALSAGNGVTK HHHHCHHHCCCCCCC	32.90	17192257
864	Phosphorylation	GNGVTKVS------- CCCCCCCC-------	35.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KI18B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KI18B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KI18B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MARE1_HUMAN	MAPRE1	physical	27173435
MARE3_HUMAN	MAPRE3	physical	27173435
KIF2C_HUMAN	KIF2C	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KI18B_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-413; SER-674 ANDSER-685, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-413; THR-578; SER-651;SER-674; SER-685 AND THR-686, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-674; SER-685 ANDTHR-686, AND MASS SPECTROMETRY.	18220336 [Abstract]