IP6K1_HUMAN - dbPTM
IP6K1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IP6K1_HUMAN
UniProt AC Q92551
Protein Name Inositol hexakisphosphate kinase 1
Gene Name IP6K1
Organism Homo sapiens (Human).
Sequence Length 441
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4..
Protein Sequence MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDDHTVCKPLISREQRFYESLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETVEQDDTTEREQPRRKHSRRSLHRSGSGSDHKEEKASLSLETSESSQEAKSPKVELHSHSEVPFQMLDGNSGLSSEKISHNPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFKYPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSATLGVRVCGMQVYQLDTGHYLCRNKYYGRGLSIEGFRNALYQYLHNGLDLRRDLFEPILSKLRGLKAVLERQASYRFYSSSLLVIYDGKECRAESCLDRRSEMRLKHLDMVLPEVASSCGPSTSPSNTSPEAGPSSQPKVDVRMIDFAHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQMRDENQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
49UbiquitinationYDDHTVCKPLISREQ
CCCCCCCHHHCCHHH		38.22-
118PhosphorylationEQPRRKHSRRSLHRS
CCCCHHHHHHHHHCC		32.21-
121PhosphorylationRRKHSRRSLHRSGSG
CHHHHHHHHHCCCCC		27.6726055452
125PhosphorylationSRRSLHRSGSGSDHK
HHHHHHCCCCCCCCH		26.9430576142
127PhosphorylationRSLHRSGSGSDHKEE
HHHHCCCCCCCCHHH		36.0530576142
129PhosphorylationLHRSGSGSDHKEEKA
HHCCCCCCCCHHHHH		37.9325072903
137PhosphorylationDHKEEKASLSLETSE
CCHHHHHHCEEECCC		29.5623312004
139PhosphorylationKEEKASLSLETSESS
HHHHHHCEEECCCCC		22.9728985074
142PhosphorylationKASLSLETSESSQEA
HHHCEEECCCCCCHH		42.9923312004
143PhosphorylationASLSLETSESSQEAK
HHCEEECCCCCCHHC		26.5525159151
145PhosphorylationLSLETSESSQEAKSP
CEEECCCCCCHHCCC		36.7725159151
146PhosphorylationSLETSESSQEAKSPK
EEECCCCCCHHCCCC		28.1725159151
150UbiquitinationSESSQEAKSPKVELH
CCCCCHHCCCCEEEE		67.54-
151PhosphorylationESSQEAKSPKVELHS
CCCCHHCCCCEEEEC		36.6821712546
160PhosphorylationKVELHSHSEVPFQML
CEEEECCCCCCCEEC		43.2228555341
171PhosphorylationFQMLDGNSGLSSEKI
CEECCCCCCCCCHHC		46.7928555341
174PhosphorylationLDGNSGLSSEKISHN
CCCCCCCCCHHCCCC		39.7225627689
177UbiquitinationNSGLSSEKISHNPWS
CCCCCCHHCCCCCCH		52.00-
184PhosphorylationKISHNPWSLRCHKQQ
HCCCCCCHHHHHHHH		13.7525159151
189UbiquitinationPWSLRCHKQQLSRMR
CCHHHHHHHHHHHHH		43.28-
199PhosphorylationLSRMRSESKDRKLYK
HHHHHCCCCHHHHHH		40.89-
279PhosphorylationHYLCRNKYYGRGLSI
CEEECCCCCCCCCCH		18.0726074081
280PhosphorylationYLCRNKYYGRGLSIE
EEECCCCCCCCCCHH		11.2726074081
313PhosphorylationDLFEPILSKLRGLKA
HHHHHHHHHHHCHHH		30.2926471730
331PhosphorylationRQASYRFYSSSLLVI
HHHHHCEECCEEEEE		9.9222817900
370PhosphorylationMVLPEVASSCGPSTS
HHHHHHHHHCCCCCC		31.1923401153
371PhosphorylationVLPEVASSCGPSTSP
HHHHHHHHCCCCCCC		17.2323663014
375PhosphorylationVASSCGPSTSPSNTS
HHHHCCCCCCCCCCC		27.1423401153
376PhosphorylationASSCGPSTSPSNTSP
HHHCCCCCCCCCCCC		48.0323663014
377PhosphorylationSSCGPSTSPSNTSPE
HHCCCCCCCCCCCCC		30.5730278072
379PhosphorylationCGPSTSPSNTSPEAG
CCCCCCCCCCCCCCC		53.1323663014
381PhosphorylationPSTSPSNTSPEAGPS
CCCCCCCCCCCCCCC		50.4223663014
382PhosphorylationSTSPSNTSPEAGPSS
CCCCCCCCCCCCCCC		25.6223663014
388PhosphorylationTSPEAGPSSQPKVDV
CCCCCCCCCCCCEEE		40.4623663014
389PhosphorylationSPEAGPSSQPKVDVR
CCCCCCCCCCCEEEE		54.3523663014
403PhosphorylationRMIDFAHSTFKGFRD
EEEECCCCCCCCCCC		31.9124260401
422PhosphorylationHDGPDRGYVFGLENL
CCCCCCCEEECHHHH		8.1024719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IP6K1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IP6K1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IP6K1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EXOS7_HUMANEXOSC7physical
16189514
R3GEF_HUMANRAB3IL1physical
11516400
DDB1_HUMANDDB1physical
25349427
CUL4A_HUMANCUL4Aphysical
25349427
RBX1_HUMANRBX1physical
25349427
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IP6K1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, AND MASSSPECTROMETRY.

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