R3GEF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: R3GEF_HUMAN
• UniProt AC: Q8TBN0
• Protein Name: Guanine nucleotide exchange factor for Rab-3A
• Gene Name: RAB3IL1
• Organism: Homo sapiens (Human).
• Sequence Length: 382
• Protein Description: Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B..
• Protein Sequence: MWSGPPQPDQGLPPPLAAVPVPWKSTDPCQGHRESPGALVETSAGEEAQGQEGPAAAQLDVLRLRSSSMEIREKGSEFLKEELHRAQKELKLKDEECERLSKVREQLEQELEELTASLFEEAHKMVREANMKQAASEKQLKEARGKIDMLQAEVTALKTLVITSTPASPNRELHPQLLSPTKAGPRKGHSRHKSTSSTLCPAVCPAAGHTLTPDREGKEVDTILFAEFQAWRESPTLDKTCPFLERVYREDVGPCLDFTMQELSVLVRAAVEDNTLTIEPVASQTLPTVKVAEVDCSSTNTCALSGLTRTCRHRIRLGDSKSHYYISPSSRARITAVCNFFTYIRYIQQGLVRQDAEPMFWEIMRLRKEMSLAKLGFFPQEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3 (in isoform 2)	Phosphorylation	-	39.87	24043423
4 (in isoform 2)	Phosphorylation	-	23.53	24043423
25	Phosphorylation	AVPVPWKSTDPCQGH CCCCCCCCCCCCCCC	33.89	25627689
26	Phosphorylation	VPVPWKSTDPCQGHR CCCCCCCCCCCCCCC	39.99	25627689
35	Phosphorylation	PCQGHRESPGALVET CCCCCCCCCCCEEEC	28.70	25159151
66	Phosphorylation	LDVLRLRSSSMEIRE HHHHHHHHCCHHHHH	31.21	28450419
67	Phosphorylation	DVLRLRSSSMEIREK HHHHHHHCCHHHHHH	27.54	28450419
68	Phosphorylation	VLRLRSSSMEIREKG HHHHHHCCHHHHHHH	22.98	28450419
74	Ubiquitination	SSMEIREKGSEFLKE CCHHHHHHHHHHHHH	58.87	29967540
80	Ubiquitination	EKGSEFLKEELHRAQ HHHHHHHHHHHHHHH	55.23	29967540
121	Ubiquitination	LTASLFEEAHKMVRE HHHHHHHHHHHHHHH	49.06	29967540
127	Ubiquitination	EEAHKMVREANMKQA HHHHHHHHHHHHHHH	33.54	29967540
146	Ubiquitination	QLKEARGKIDMLQAE HHHHHHHCHHHHHHH	29.94	29967540
159	Phosphorylation	AEVTALKTLVITSTP HHHHHHEEEEEECCC	27.40	20068231
163	Phosphorylation	ALKTLVITSTPASPN HHEEEEEECCCCCCC	21.04	23898821
164	Phosphorylation	LKTLVITSTPASPNR HEEEEEECCCCCCCC	22.67	25159151
165	Phosphorylation	KTLVITSTPASPNRE EEEEEECCCCCCCCC	17.77	30266825
168	Phosphorylation	VITSTPASPNRELHP EEECCCCCCCCCCCH	24.74	28731282
179	Phosphorylation	ELHPQLLSPTKAGPR CCCHHHCCCCCCCCC	38.83	30266825
181	Phosphorylation	HPQLLSPTKAGPRKG CHHHCCCCCCCCCCC	30.10	30266825
190	Phosphorylation	AGPRKGHSRHKSTSS CCCCCCCCCCCCCCC	44.76	26074081
194	Phosphorylation	KGHSRHKSTSSTLCP CCCCCCCCCCCCCCC	27.65	25159151
195	Phosphorylation	GHSRHKSTSSTLCPA CCCCCCCCCCCCCCC	31.34	30576142
196	Phosphorylation	HSRHKSTSSTLCPAV CCCCCCCCCCCCCCC	28.54	29116813
197	Phosphorylation	SRHKSTSSTLCPAVC CCCCCCCCCCCCCCC	26.03	29116813
198	Phosphorylation	RHKSTSSTLCPAVCP CCCCCCCCCCCCCCC	31.95	29496963
210	Phosphorylation	VCPAAGHTLTPDREG CCCCCCCCCCCCCCC	31.26	25159151
212	Phosphorylation	PAAGHTLTPDREGKE CCCCCCCCCCCCCCC	25.05	25159151
288	Phosphorylation	VASQTLPTVKVAEVD CCCCCCCCEEEEEEE	35.75	23403867
298	Phosphorylation	VAEVDCSSTNTCALS EEEEECCCCCCHHHH	31.82	23403867
320	Phosphorylation	HRIRLGDSKSHYYIS CEEECCCCCCCEEEC	33.97	28857561
324	Phosphorylation	LGDSKSHYYISPSSR CCCCCCCEEECCHHH	15.02	28152594
325	Phosphorylation	GDSKSHYYISPSSRA CCCCCCEEECCHHHH	6.90	29759185
327	Phosphorylation	SKSHYYISPSSRARI CCCCEEECCHHHHHH	11.56	28152594
329	Phosphorylation	SHYYISPSSRARITA CCEEECCHHHHHHHH	26.18	28152594
330	Phosphorylation	HYYISPSSRARITAV CEEECCHHHHHHHHH	33.09	28152594

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of R3GEF_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of R3GEF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of R3GEF_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUD18_HUMAN	NUDT18	physical	16189514
R3GEF_HUMAN	RAB3IL1	physical	16189514
RB11A_HUMAN	RAB11A	physical	16189514
RAB3I_HUMAN	RAB3IP	physical	16189514
R3GEF_HUMAN	RAB3IL1	physical	25416956
MTUS2_HUMAN	MTUS2	physical	25416956
SATB2_HUMAN	SATB2	physical	25416956
TIGD7_HUMAN	TIGD7	physical	25416956
RAB3I_HUMAN	RAB3IP	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
CCD57_HUMAN	CCDC57	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
RAB3I_HUMAN	RAB3IP	physical	26186194
TM102_HUMAN	TMEM102	physical	26186194
LIPA3_HUMAN	PPFIA3	physical	26186194
ATG4C_HUMAN	ATG4C	physical	26186194
AMOL1_HUMAN	AMOTL1	physical	26186194
AMOT_HUMAN	AMOT	physical	26186194
RAB8A_HUMAN	RAB8A	physical	26186194
SUGP2_HUMAN	SUGP2	physical	26186194
IF1AX_HUMAN	EIF1AX	physical	26186194
C102A_HUMAN	CCDC102A	physical	26186194
OPTN_HUMAN	OPTN	physical	26186194
PPIL4_HUMAN	PPIL4	physical	26186194
ODFP2_HUMAN	ODF2	physical	26186194
TM102_HUMAN	TMEM102	physical	28514442
RAB3I_HUMAN	RAB3IP	physical	28514442
LIPA3_HUMAN	PPFIA3	physical	28514442
OPTN_HUMAN	OPTN	physical	28514442
ATG4C_HUMAN	ATG4C	physical	28514442
C102A_HUMAN	CCDC102A	physical	28514442
SUGP2_HUMAN	SUGP2	physical	28514442
AMOT_HUMAN	AMOT	physical	28514442
PPIL4_HUMAN	PPIL4	physical	28514442
RAB8A_HUMAN	RAB8A	physical	28514442
RAB3I_HUMAN	RAB3IP	physical	27173435
PDLI7_HUMAN	PDLIM7	physical	27173435
TM102_HUMAN	TMEM102	physical	27173435
TPC2L_HUMAN	TRAPPC2L	physical	27173435
TPC10_HUMAN	TRAPPC10	physical	27173435
M21D2_HUMAN	MB21D2	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.