SC11A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SC11A_HUMAN
• UniProt AC: P67812
• Protein Name: Signal peptidase complex catalytic subunit SEC11A
• Gene Name: SEC11A
• Organism: Homo sapiens (Human).
• Sequence Length: 179
• Subcellular Localization: Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein.
• Protein Description: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum..
• Protein Sequence: MLSLDFLDDVRRMNKRQLYYQVLNFGMIVSSALMIWKGLMVITGSESPIVVVLSGSMEPAFHRGDLLFLTNRVEDPIRVGEIVVFRIEGREIPIVHRVLKIHEKQNGHIKFLTKGDNNAVDDRGLYKQGQHWLEKKDVVGRARGFVPYIGIVTILMNDYPKFKYAVLFLLGLFVLVHRE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Sulfoxidation	-------MLSLDFLD -------CCCCHHHH	5.31	21406390
3	Phosphorylation	-----MLSLDFLDDV -----CCCCHHHHHH	25.29	20068231
4 (in isoform 2)	Phosphorylation	-	4.80	25159151
5 (in isoform 2)	Phosphorylation	-	38.39	25159151
19	Phosphorylation	RMNKRQLYYQVLNFG HHCHHHHHHHHHHHH	5.41	25262027
20	Phosphorylation	MNKRQLYYQVLNFGM HCHHHHHHHHHHHHH	10.75	25262027
30	Phosphorylation	LNFGMIVSSALMIWK HHHHHHHHHHHHHHC	10.04	25627689
31	Phosphorylation	NFGMIVSSALMIWKG HHHHHHHHHHHHHCC	17.96	25627689
43	Phosphorylation	WKGLMVITGSESPIV HCCEEEECCCCCCEE	24.20	20068231
45	Phosphorylation	GLMVITGSESPIVVV CEEEECCCCCCEEEE	26.67	20068231
47	Phosphorylation	MVITGSESPIVVVLS EEECCCCCCEEEEEE	22.94	26074081
54	Phosphorylation	SPIVVVLSGSMEPAF CCEEEEEECCCCCCC	19.74	26074081
56	Phosphorylation	IVVVLSGSMEPAFHR EEEEEECCCCCCCCC	19.32	20068231
70	Phosphorylation	RGDLLFLTNRVEDPI CCCEEEEECCCCCCC	17.40	26074081
74	Ubiquitination	LFLTNRVEDPIRVGE EEEECCCCCCCCCCE	55.63	-
78	Ubiquitination	NRVEDPIRVGEIVVF CCCCCCCCCCEEEEE	35.46	21890473
84	Ubiquitination	IRVGEIVVFRIEGRE CCCCEEEEEEECCEE	3.07	-
88	Ubiquitination	EIVVFRIEGREIPIV EEEEEEECCEECEEE	48.19	21890473
100	Ubiquitination	PIVHRVLKIHEKQNG EEEEEEEEHHHHHCC	38.88	-
101	Ubiquitination	IVHRVLKIHEKQNGH EEEEEEEHHHHHCCE	4.42	21890473
104	Ubiquitination	RVLKIHEKQNGHIKF EEEEHHHHHCCEEEE	34.60	21906983
109	Ubiquitination	HEKQNGHIKFLTKGD HHHHCCEEEEEECCC	3.41	21890473
110	Ubiquitination	EKQNGHIKFLTKGDN HHHCCEEEEEECCCC	28.75	-
110	Ubiquitination	EKQNGHIKFLTKGDN HHHCCEEEEEECCCC	28.75	-
114	Ubiquitination	GHIKFLTKGDNNAVD CEEEEEECCCCCCCC	67.43	21906983
114	Ubiquitination	GHIKFLTKGDNNAVD CEEEEEECCCCCCCC	67.43	21890473
127	Ubiquitination	VDDRGLYKQGQHWLE CCCCCHHHCCCHHHH	53.66	21906983
127	Ubiquitination	VDDRGLYKQGQHWLE CCCCCHHHCCCHHHH	53.66	21890473
135	Ubiquitination	QGQHWLEKKDVVGRA CCCHHHHHCCCCHHH	52.70	-
135	Ubiquitination	QGQHWLEKKDVVGRA CCCHHHHHCCCCHHH	52.70	21890473
136	Ubiquitination	GQHWLEKKDVVGRAR CCHHHHHCCCCHHHC	46.51	-
146 (in isoform 4)	Phosphorylation	-	3.81	27732954
148	Phosphorylation	RARGFVPYIGIVTIL HHCCCCCEEEEEEHH	13.38	25348772
150 (in isoform 4)	Phosphorylation	-	11.50	27732954
151 (in isoform 4)	Phosphorylation	-	1.47	27732954
153	Phosphorylation	VPYIGIVTILMNDYP CCEEEEEEHHCCCCH	13.38	25348772
159	Phosphorylation	VTILMNDYPKFKYAV EEHHCCCCHHHHHHH	11.88	25348772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SC11A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SC11A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SC11A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
S35F6_HUMAN	SLC35F6	physical	16169070

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.