MBOA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MBOA2_HUMAN
• UniProt AC: Q6ZWT7
• Protein Name: Lysophospholipid acyltransferase 2
• Gene Name: MBOAT2
• Organism: Homo sapiens (Human).
• Sequence Length: 520
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle..
• Protein Sequence: MATTSTTGSTLLQPLSNAVQLPIDQVNFVVCQLFALLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWYALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKDEELTSSQRDLAVRRMPSLLEYLSYNCNFMGILAGPLCSYKDYITFIEGRSYHITQSGENGKEETQYERTEPSPNTAVVQKLLVCGLSLLFHLTICTTLPVEYNIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFKMFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYYCLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKKFDEGENSLGQNSFSTTNNVCNQNQEIASRHSSLKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Phosphorylation	LHSSKTSSFIRHVVA HHCCCCHHHHHHHHH	29.89	24719451
119	Phosphorylation	VCQVTRVYIFDYGQY HCCEEEEEEEECCCC	7.80	24043423
123	Phosphorylation	TRVYIFDYGQYSADF EEEEEEECCCCCCCC	8.72	24043423
126	Phosphorylation	YIFDYGQYSADFSGP EEEECCCCCCCCCCC	11.06	24043423
127	Phosphorylation	IFDYGQYSADFSGPM EEECCCCCCCCCCCE	17.30	24043423
131	Phosphorylation	GQYSADFSGPMMIIT CCCCCCCCCCEEEEE	42.40	24043423
138	Phosphorylation	SGPMMIITQKITSLA CCCEEEEEHHHHHHH	16.94	24043423
160	Phosphorylation	FRKDEELTSSQRDLA CCCCHHCCHHHHHHH	29.61	29083192
161	Phosphorylation	RKDEELTSSQRDLAV CCCHHCCHHHHHHHH	36.78	29083192
162	Phosphorylation	KDEELTSSQRDLAVR CCHHCCHHHHHHHHH	24.81	29083192
198	Phosphorylation	PLCSYKDYITFIEGR CCCCCCCEEEEECCC	9.56	-
217	Acetylation	TQSGENGKEETQYER EECCCCCCEECCCCC	65.05	23236377
217	Ubiquitination	TQSGENGKEETQYER EECCCCCCEECCCCC	65.05	-
220	Phosphorylation	GENGKEETQYERTEP CCCCCEECCCCCCCC	37.23	28796482
222	Phosphorylation	NGKEETQYERTEPSP CCCEECCCCCCCCCC	18.13	28796482
276	Phosphorylation	SWPTKIIYLYISLLA CCCHHHHHHHHHHHH	9.27	22817900
321	Phosphorylation	AARWDLISNLRIQQI CCHHHHHHHHEEEEE	36.79	24719451
331	Phosphorylation	RIQQIEMSTSFKMFL EEEEEEECCCHHHHH	14.22	24043423
332	Phosphorylation	IQQIEMSTSFKMFLD EEEEEECCCHHHHHH	36.55	24043423
333	Phosphorylation	QQIEMSTSFKMFLDN EEEEECCCHHHHHHC	18.63	24043423
437	Phosphorylation	VVPFVLLSIKPSLTF HHCHHHEEECCCHHH	25.14	24719451
472	Ubiquitination	VKKTQRRKNTHENIQ CCCCHHHCCCCCCHH	69.27	-
474	Phosphorylation	KTQRRKNTHENIQLS CCHHHCCCCCCHHHH	33.33	25159151
481	Phosphorylation	THENIQLSQSKKFDE CCCCHHHHHCCCCCC	18.94	30266825
483	Phosphorylation	ENIQLSQSKKFDEGE CCHHHHHCCCCCCCC	34.14	30266825
492	Phosphorylation	KFDEGENSLGQNSFS CCCCCCCCCCCCCCH	29.58	27251275
497	Phosphorylation	ENSLGQNSFSTTNNV CCCCCCCCCHHCCCC	16.82	23898821
499	Phosphorylation	SLGQNSFSTTNNVCN CCCCCCCHHCCCCHH	33.86	28555341
500	Phosphorylation	LGQNSFSTTNNVCNQ CCCCCCHHCCCCHHH	31.37	28348404
501	Phosphorylation	GQNSFSTTNNVCNQN CCCCCHHCCCCHHHH	24.48	28348404
513	Phosphorylation	NQNQEIASRHSSLKQ HHHHHHHHHHHHCCC	35.87	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MBOA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MBOA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MBOA2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MBOA2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.