TM41B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM41B_HUMAN
• UniProt AC: Q5BJD5
• Protein Name: Transmembrane protein 41B
• Gene Name: TMEM41B
• Organism: Homo sapiens (Human).
• Sequence Length: 291
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Required for normal motor neuron development..
• Protein Sequence: MAKGRVAERSQLGAHHTTPVGDGAAGTRGLAAPGSRDHQKEKSWVEAGSARMSLLILVSIFLSAAFVMFLVYKNFPQLSEEERVNMKVPRDMDDAKALGKVLSKYKDTFYVQVLVAYFATYIFLQTFAIPGSIFLSILSGFLYPFPLALFLVCLCSGLGASFCYMLSYLVGRPVVYKYLTEKAVKWSQQVERHREHLINYIIFLRITPFLPNWFINITSPVINVPLKVFFIGTFLGVAPPSFVAIKAGTTLYQLTTAGEAVSWNSIFILMILAVLSILPAIFQKKLKQKFE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	KGRVAERSQLGAHHT CCCCCCHHHCCCCCC	22.66	23401153
17	Phosphorylation	SQLGAHHTTPVGDGA HHCCCCCCCCCCCCC	23.95	21712546
18	Phosphorylation	QLGAHHTTPVGDGAA HCCCCCCCCCCCCCC	16.18	23401153
27	Phosphorylation	VGDGAAGTRGLAAPG CCCCCCCCCCCCCCC	19.48	24732914
35	Phosphorylation	RGLAAPGSRDHQKEK CCCCCCCCCCHHHHC	33.21	25159151
49	Phosphorylation	KSWVEAGSARMSLLI CCHHHHHHHHHHHHH	21.54	22210691
53	Phosphorylation	EAGSARMSLLILVSI HHHHHHHHHHHHHHH	17.92	22210691
59	Phosphorylation	MSLLILVSIFLSAAF HHHHHHHHHHHHHHH	12.27	22210691
79	Phosphorylation	YKNFPQLSEEERVNM HHCCCCCCHHHHHCC	37.40	21815630
87 (in isoform 2)	Ubiquitination	-	43.83	21890473
87	Ubiquitination	EEERVNMKVPRDMDD HHHHHCCCCCCCHHH	43.83	22817900
87 (in isoform 1)	Ubiquitination	-	43.83	21890473
96	Ubiquitination	PRDMDDAKALGKVLS CCCHHHHHHHHHHHH	51.65	21906983
96 (in isoform 2)	Ubiquitination	-	51.65	21890473
96 (in isoform 1)	Ubiquitination	-	51.65	21890473
100	Ubiquitination	DDAKALGKVLSKYKD HHHHHHHHHHHHHCC	40.63	22817900
100 (in isoform 2)	Ubiquitination	-	40.63	21890473
100 (in isoform 1)	Ubiquitination	-	40.63	21890473
100	2-Hydroxyisobutyrylation	DDAKALGKVLSKYKD HHHHHHHHHHHHHCC	40.63	-
104	Ubiquitination	ALGKVLSKYKDTFYV HHHHHHHHHCCHHHH	52.76	22817900
135 (in isoform 2)	Phosphorylation	-	2.72	20860994
140 (in isoform 2)	Phosphorylation	-	17.09	20860994
182	Ubiquitination	VYKYLTEKAVKWSQQ HHHHHHHHHHHHHHH	53.93	27667366
185 (in isoform 1)	Ubiquitination	-	46.09	21890473
185	Ubiquitination	YLTEKAVKWSQQVER HHHHHHHHHHHHHHH	46.09	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TM41B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM41B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM41B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DPYS_HUMAN	DPYS	physical	26186194
APOB_HUMAN	APOB	physical	26186194
APOB_HUMAN	APOB	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18 AND SER-35, AND MASSSPECTROMETRY.
PubMed: 18691976