DPYS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DPYS_HUMAN
• UniProt AC: Q14117
• Protein Name: Dihydropyrimidinase
• Gene Name: DPYS
• Organism: Homo sapiens (Human).
• Sequence Length: 519
• Protein Description: Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate..
• Protein Sequence: MAAPSRLLIRGGRVVNDDFSEVADVLVEDGVVRALGHDLLPPGGAPAGLRVLDAAGKLVLPGGIDTHTHMQFPFMGSRSIDDFHQGTKAALSGGTTMIIDFAIPQKGGSLIEAFETWRSWADPKVCCDYSLHVAVTWWSDQVKEEMKILVQDKGVNSFKMFMAYKDLYMVTDLELYEAFSRCKEIGAIAQVHAENGDLIAEGAKKMLALGITGPEGHELCRPEAVEAEATLRAITIASAVNCPLYIVHVMSKSAAKVIADARRDGKVVYGEPIAASLGTDGTHYWNKEWHHAAHHVMGPPLRPDPSTPDFLMNLLANDDLTTTGTDNCTFNTCQKALGKDDFTKIPNGVNGVEDRMSVIWEKGVHSGKMDENRFVAVTSTNAAKIFNLYPRKGRIAVGSDADIVIWDPKGTRTISAKTHHQAVNFNIFEGMVCHGVPLVTISRGKVVYEAGVFSVTAGDGKFIPRKPFAEYIYKRIKQRDRTCTPTPVERAPYKGEVATLKSRVTKEDATAGTRKQAHP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	Phosphorylation	FPFMGSRSIDDFHQG CCCCCCCCHHHHHHH	31.87	28857561
159	N6-carboxylysine	DKGVNSFKMFMAYKD CCCCCCHHHHHHHHC	30.92	-
159	Carboxylation	DKGVNSFKMFMAYKD CCCCCCHHHHHHHHC	30.92	-
256	Succinylation	VMSKSAAKVIADARR ECCHHHHHHHHHHHC	33.61	-
256	Succinylation	VMSKSAAKVIADARR ECCHHHHHHHHHHHC	33.61	-
409	Acetylation	DIVIWDPKGTRTISA CEEEECCCCCEEEEC	71.13	24885305
482	Phosphorylation	RIKQRDRTCTPTPVE HHHHCCCCCCCCCCC	25.64	28857561
484	Phosphorylation	KQRDRTCTPTPVERA HHCCCCCCCCCCCCC	29.59	28258704
486	Phosphorylation	RDRTCTPTPVERAPY CCCCCCCCCCCCCCC	23.08	25072903
499	Phosphorylation	PYKGEVATLKSRVTK CCCCCCEEHHHCCCH	39.64	28258704
501	Methylation	KGEVATLKSRVTKED CCCCEEHHHCCCHHH	31.68	-
505	Phosphorylation	ATLKSRVTKEDATAG EEHHHCCCHHHCCCC	27.83	28258704
510	Phosphorylation	RVTKEDATAGTRKQA CCCHHHCCCCCCCCC	37.63	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DPYS_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DPYS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DPYS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DPYL3_HUMAN	DPYSL3	physical	28514442
DPYL2_HUMAN	DPYSL2	physical	28514442
DPYL5_HUMAN	DPYSL5	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.