SAR1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAR1A_HUMAN
• UniProt AC: Q9NR31
• Protein Name: GTP-binding protein SAR1a
• Gene Name: SAR1A
• Organism: Homo sapiens (Human).
• Sequence Length: 198
• Subcellular Localization: Endoplasmic reticulum. Golgi apparatus.
• Protein Description: Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES)..
• Protein Sequence: MSFIFEWIYNGFSSVLQFLGLYKKSGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPTSEELTIAGMTFTTFDLGGHEQARRVWKNYLPAINGIVFLVDCADHSRLVESKVELNALMTDETISNVPILILGNKIDRTDAISEEKLREIFGLYGQTTGKGNVTLKELNARPMEVFMCSVLKRQGYGEGFRWLSQYID

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSFIFEWIY ------CCCHHHHHH	27.35	23401153
13	Phosphorylation	EWIYNGFSSVLQFLG HHHHHCHHHHHHHHH	22.42	23401153
14	Phosphorylation	WIYNGFSSVLQFLGL HHHHCHHHHHHHHHH	25.28	23401153
25	Phosphorylation	FLGLYKKSGKLVFLG HHHHHCCCCCEEEEE	36.69	23401153
27	Ubiquitination	GLYKKSGKLVFLGLD HHHCCCCCEEEEEEC	48.87	21906983
27	2-Hydroxyisobutyrylation	GLYKKSGKLVFLGLD HHHCCCCCEEEEEEC	48.87	-
39	Phosphorylation	GLDNAGKTTLLHMLK EECCCCCEEHHHHHC	23.04	21406692
40	Phosphorylation	LDNAGKTTLLHMLKD ECCCCCEEHHHHHCC	30.70	21406692
46	Acetylation	TTLLHMLKDDRLGQH EEHHHHHCCCCCCCC	50.43	25953088
46	Ubiquitination	TTLLHMLKDDRLGQH EEHHHHHCCCCCCCC	50.43	-
60	Phosphorylation	HVPTLHPTSEELTIA CCCCCCCCCCCEEEC	37.71	-
89	Phosphorylation	ARRVWKNYLPAINGI HHHHHHHHHHHHCEE	15.44	-
103	Ubiquitination	IVFLVDCADHSRLVE EEEEEECCCCHHHHC	17.06	-
103	Acetylation	IVFLVDCADHSRLVE EEEEEECCCCHHHHC	17.06	-
120	Phosphorylation	VELNALMTDETISNV HHHHHHCCCCCCCCC	31.37	21406692
123	Phosphorylation	NALMTDETISNVPIL HHHCCCCCCCCCCEE	32.30	21406692
123	Ubiquitination	NALMTDETISNVPIL HHHCCCCCCCCCCEE	32.30	21890473
125	Phosphorylation	LMTDETISNVPILIL HCCCCCCCCCCEEEE	38.91	21406692
139	Ubiquitination	LGNKIDRTDAISEEK ECCCCCCCCCCCHHH	26.49	-
139	Phosphorylation	LGNKIDRTDAISEEK ECCCCCCCCCCCHHH	26.49	29255136
143	Phosphorylation	IDRTDAISEEKLREI CCCCCCCCHHHHHHH	41.23	28102081
146	2-Hydroxyisobutyrylation	TDAISEEKLREIFGL CCCCCHHHHHHHHHC	49.11	-
146	Ubiquitination	TDAISEEKLREIFGL CCCCCHHHHHHHHHC	49.11	21906983
146	Acetylation	TDAISEEKLREIFGL CCCCCHHHHHHHHHC	49.11	23749302
154	Phosphorylation	LREIFGLYGQTTGKG HHHHHHCCCCCCCCC	13.94	28152594
157	Phosphorylation	IFGLYGQTTGKGNVT HHHCCCCCCCCCCEE	32.90	28152594
158	Phosphorylation	FGLYGQTTGKGNVTL HHCCCCCCCCCCEEH	29.07	28152594
160	2-Hydroxyisobutyrylation	LYGQTTGKGNVTLKE CCCCCCCCCCEEHHH	45.26	-
164	Phosphorylation	TTGKGNVTLKELNAR CCCCCCEEHHHHCCC	35.79	-
166	2-Hydroxyisobutyrylation	GKGNVTLKELNARPM CCCCEEHHHHCCCCE	51.28	-
166	Ubiquitination	GKGNVTLKELNARPM CCCCEEHHHHCCCCE	51.28	21906983
166	Acetylation	GKGNVTLKELNARPM CCCCEEHHHHCCCCE	51.28	27452117
178	Glutathionylation	RPMEVFMCSVLKRQG CCEEEEEHHHHHHCC	1.40	22555962
179	Phosphorylation	PMEVFMCSVLKRQGY CEEEEEHHHHHHCCC	20.78	30206219
182	Ubiquitination	VFMCSVLKRQGYGEG EEEHHHHHHCCCCCH	40.29	-
182	Acetylation	VFMCSVLKRQGYGEG EEEHHHHHHCCCCCH	40.29	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SAR1A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAR1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAR1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
TPD52_HUMAN	TPD52	physical	22939629
TRAF3_HUMAN	TRAF3	physical	21988832
HEM3_HUMAN	HMBS	physical	26344197
SC31A_HUMAN	SEC31A	physical	26344197
SAR1B_HUMAN	SAR1B	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-139, AND MASSSPECTROMETRY.
PubMed: 18669648